Basic Science and Craniofacial Biology

Research Output 1967 2017

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2017

12-Year Use of a Digital Reference Library (VitalBook) at a U.S. Dental School: Students' and Alumni Perceptions

Spielman, A. I., Maas, E. & Eisenberg, E. S. Oct 1 2017 In : Journal of dental education. 81, 10, p. 1243-1251 9 p.

Research output: Research - peer-reviewArticle

Digital Libraries
Dental Students
Dental Schools
Students
Textbooks

Ablation of hepatic production of the acid-labile subunit in Bovine-GH transgenic mice: Effects on organ and skeletal growth

Liu, Z., Han, T., Fishman, S., Butler, J., Zimmermann, T., Tremblay, F., Harbison, C., Agrawal, N., Kopchick, J. J., Schaffler, M. B. & Yakar, S. Aug 1 2017 In : Endocrinology. 158, 8, p. 2556-2571 16 p.

Research output: Research - peer-reviewArticle

Transgenic Mice
Intercellular Signaling Peptides and Proteins
Acids
Liver
Growth

A Model Sea Urchin Spicule Matrix Protein, rSpSM50, Is a Hydrogelator That Modifies and Organizes the Mineralization Process

Jain, G., Pendola, M., Huang, Y. C., Gebauer, D. & Evans, J. S. May 30 2017 In : Biochemistry. 56, 21, p. 2663-2675 13 p.

Research output: Research - peer-reviewArticle

Sea Urchins
Calcium Carbonate
Proteins
Strongylocentrotus purpuratus
Hydrogels

A novel heterozygous IGF-1 receptor mutation associated with hypoglycemia

Solomon-Zemler, R., Basel-Vanagaite, L., Steier, D., Yakar, S., Mel, E., Phillip, M., Bazak, L., Bercovich, D., Werner, H. & De Vries, L. Aug 1 2017 In : Endocrine Connections. 6, 6, p. 395-403 9 p.

Research output: Research - peer-reviewArticle

Somatomedin Receptors
IGF Type 1 Receptor
Hypoglycemia
Mutation
Mothers

An Overview of the Models in Reporting School Data on Dental Credentialing Examinations

Tsai, T. H., Spielman, A. I. & Kramer, G. A. Feb 1 2017 In : Journal of dental education. 81, 2, p. 178-189 12 p.

Research output: Research - peer-reviewArticle

Credentialing
Tooth
Research Design
examination
school

Antibacterial and bioactive coatings on titanium implant surfaces

Kulkarni Aranya, A., Pushalkar, S., Zhao, M., LeGeros, R. Z., Zhang, Y. & Saxena, D. Aug 1 2017 In : Journal of Biomedical Materials Research - Part A. 105, 8, p. 2218-2227 10 p.

Research output: Research - peer-reviewArticle

Titanium
Coatings
Dental prostheses
Calcium phosphate
calcium phosphate

A preliminary study on the relationship between iron and black extrinsic tooth stain in children

Zhang, F., Li, Y., Xun, Z., Zhang, Q., Liu, H. & Chen, F. Jun 1 2017 In : Letters in Applied Microbiology. 64, 6, p. 424-429 6 p.

Research output: Research - peer-reviewArticle

Tooth
Coloring Agents
Iron
Genes
Bacteria

Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells

Xu, J. J., Elkaddi, N., Garcia-Blanco, A., Spielman, A. I., Bachmanov, A. A., Chung, H. Y. & Ozdener, M. H. Dec 1 2017 In : Scientific Reports. 7, 1, 7483

Research output: Research - peer-reviewArticle

Epithelial Sodium Channels
Dipeptides
Small Interfering RNA
Amiloride
arginylproline

Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue

Lipchock, S. V., Spielman, A. I., Mennella, J. A., Mansfield, C. J., Hwang, L. D., Douglas, J. E. & Reed, D. R. 2017 In : Perception. 46, 3-4, p. 245-256 12 p.

Research output: Research - peer-reviewArticle

Caffeine
Messenger RNA
Tissue
Quinine
Propylthiouracil

Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry

El-Bayoumy, K., Chen, K. M., Zhang, S. M., Sun, Y. W., Amin, S., Stoner, G. & Guttenplan, J. B. Jan 17 2017 In : Chemical research in toxicology. 30, 1, p. 126-144 19 p.

Research output: Research - peer-reviewArticle

Mouth Neoplasms
Mouth
Carcinogenesis
Rubus
Animal Models

Changes in lipid membranes may trigger amyloid toxicity in Alzheimer’s disease

Drolle, E., Negoda, A., Hammond, K., Pavlov, E. & Leonenko, Z. Aug 1 2017 In : PLoS ONE. 12, 8, e0182194

Research output: Research - peer-reviewArticle

Membrane Lipids
Amyloid
Toxicity
Membranes
Alzheimer Disease
Matrix Metalloproteinase 13
Phosphorylation
Serine
Bone
Amino Acids

Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats

Qian, J., Mummalaneni, S., Phan, T. H. T., Heck, G. L., Desimone, J. A., West, D., Mahavadi, S., Hojati, D., Murthy, K. S., Rhyu, M. R., Spielman, A. I., Ozdener, M. H. & Lyall, V. Feb 1 2017 In : PLoS ONE. 12, 2, 0171335

Research output: Research - peer-reviewArticle

postnatal development
cyclic AMP
rats
Epithelial Sodium Channels
Cyclic AMP

Dental enamel formation and implications for oral health and disease

Lacruz, R. S., Habelitz, S., Wright, J. T. & Paine, M. L. Jul 1 2017 In : Physiological Reviews. 97, 3, p. 939-993 55 p.

Research output: Research - peer-reviewArticle

Mouth Diseases
Oral Health
Dental Enamel
Ameloblasts
Enamel Organ

Enamel: Molecular identity of its transepithelial ion transport system

Lacruz, R. S. Feb 28 2017 (Accepted/In press) In : Cell Calcium.

Research output: Research - peer-reviewArticle

Ion Transport
Dental Enamel
Ameloblasts
Bone and Bones
Proteins

Follicular regulatory T cells are highly permissive to R5-tropic HIV-1

Miller, S. M., Miles, B., Guo, K., Folkvord, J., Meditz, A. L., McCarter, M. D., Levy, D. N., MaWhinney, S., Santiago, M. L. & Connick, E. Sep 1 2017 In : Journal of Virology. 91, 17, e00430-17

Research output: Research - peer-reviewArticle

Human immunodeficiency virus 1
tropics
T-lymphocytes
cells
Regulatory T-Lymphocytes

Functional Prioritization and Hydrogel Regulation Phenomena Created by a Combinatorial Pearl-Associated Two-Protein Biomineralization Model System

Jain, G., Pendola, M., Huang, Y. C., Juan Colas, J., Gebauer, D., Johnson, S. & Evans, J. S. Jul 18 2017 In : Biochemistry. 56, 28, p. 3607-3618 12 p.

Research output: Research - peer-reviewArticle

Biomineralization
Hydrogel
Proteins
Nacre
Nucleation

Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors

Nichols, M., Elustondo, P. A., Warford, J., Thirumaran, A., Pavlov, E. V. & Robertson, G. S. Aug 1 2017 In : Journal of Cerebral Blood Flow and Metabolism. 37, 8, p. 3027-3041 15 p.

Research output: Research - peer-reviewArticle

Glycolysis
Neurons
mitochondrial calcium uniporter
Prosencephalon
Pyruvic Acid

IGF-1 Mediates EphrinBl Activation in Regulating Tertiary Dentin Formation

Matsumura, S., Quispe-Salcedo, A., Schiller, C. M., Shin, J. S., Locke, B. M., Yakar, S. & Shimizu, E. Sep 1 2017 In : Journal of Dental Research. 96, 10, p. 1153-1161 9 p.

Research output: Research - peer-reviewArticle

Odontoblasts
Somatomedins
Dentin
Tooth Injuries
In Vitro Techniques

MicroRNA-590-5p Stabilizes Runx2 by Targeting Smad7 During Osteoblast Differentiation

Vishal, M., Vimalraj, S., Ajeetha, R., Gokulnath, M., Keerthana, R., He, Z., Partridge, N. C. & Selvamurugan, N. Feb 1 2017 In : Journal of Cellular Physiology. 232, 2, p. 371-380 10 p.

Research output: Research - peer-reviewArticle

Osteoblasts
MicroRNAs
Genes
Core Binding Factor Alpha 1 Subunit
Messenger RNA

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

Vaeth, M., Yang, J., Yamashita, M., Zee, I., Eckstein, M., Knosp, C., Kaufmann, U., Jani, P. K., Lacruz, R. S., Flockerzi, V., Kacskovics, I., Prakriya, M. & Feske, S. Mar 15 2017 In : Nature Communications. 8, 14714

Research output: Research - peer-reviewArticle

Cellular Immunity
Calcium
T-Lymphocytes
Calcium Release Activated Calcium Channels
immunity

Osmotic regulation of the mitochondrial permeability transition pore investigated by light scattering, fluorescence and electron microscopy techniques

Baev, A. Y., Elustondo, P. A., Negoda, A. & Pavlov, E. V. 2017 (Accepted/In press) In : Analytical Biochemistry.

Research output: Research - peer-reviewArticle

Fluorescence microscopy
Light scattering
Electron microscopy
Calcium
Membranes

Polymorphs, proteins, and nucleation theory: A critical analysis

Evans, J. S. Apr 21 2017 In : Minerals. 7, 4, 62

Research output: Research - peer-reviewArticle

critical analysis
nucleation
protein
Polymorphism
Nucleation

Potent inhibition of HIV-1 replication in resting CD4 T Cells by resveratrol and pterostilbene

Chan, C. N., Trinité, B. & Levy, D. N. Sep 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 9, e00408

Research output: Research - peer-reviewArticle

HIV-1
T-Lymphocytes
resveratrol
pterostilbene
HIV Infections
Electromagnetic Fields
Osteoblasts
MicroRNAs
Mesenchymal Stromal Cells
Transforming Growth Factor beta

Pyroptosis, superinfection, and the maintenance of the latent reservoir in HIV-1 infection

Wodarz, D. & Levy, D. N. Dec 1 2017 In : Scientific Reports. 7, 1, 3834

Research output: Research - peer-reviewArticle

Superinfection
HIV Infections
HIV-1
Maintenance
Pyroptosis

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

Guo, Y., Xie, C., Li, X., Yang, J., Yu, T., Zhang, R., Zhang, T., Saxena, D., Snyder, M., Wu, Y. & Li, X. May 31 2017 In : Nature Communications. 8, 15621

Research output: Research - peer-reviewArticle

Succinic Acid
G-Protein-Coupled Receptors
Mesenchymal Stromal Cells
Osteogenesis
Type 2 Diabetes Mellitus
2016

A Model Sea Urchin Spicule Matrix Protein Self-Associates To Form Mineral-Modifying Protein Hydrogels

Jain, G., Pendola, M., Rao, A., Cölfen, H. & Evans, J. S. Aug 9 2016 In : Biochemistry. 55, 31, p. 4410-4421 12 p.

Research output: Research - peer-reviewArticle

Hydrogels
Sea Urchins
Minerals
Proteins
Calcium Carbonate

A nacre protein forms mesoscale hydrogels that "hijack" the biomineralization process within a seawater environment

Pendola, M., Jain, G., Davidyants, A., Huang, Y. C., Gebauer, D. & Evans, J. S. 2016 In : CrystEngComm. 18, 40, p. 7675-7679 5 p.

Research output: Research - peer-reviewArticle

Nacre
Biomineralization
Hydrogels
Calcium Carbonate
Seawater

ANISEED 2015: A digital framework for the comparative developmental biology of ascidians

Brozovic, M. , Martin, C. , Dantec, C. , Dauga, D. , Mendez, M. , Simion, P. , Percher, M. , Laporte, B. , Scornavacca, C. , Di Gregorio, A. , Fujiwara, S. , Gineste, M. , Lowe, E. K. , Piette, J. , Racioppi, C. , Ristoratore, F. , Sasakura, Y. , Takatori, N. , Brown, T. C. , Delsuc, F. & 8 others Douzery, E., Gissi, C., McDougall, A., Nishida, H., Sawada, H., Swalla, B. J., Yasuo, H. & Lemaire, P. 2016 In : Nucleic Acids Research. 44, D1, p. D808-D818

Research output: Research - peer-reviewArticle

Urochordata
Developmental Biology
Genome
Molecular Sequence Annotation
Information Systems

Aragonite-Associated Mollusk Shell Protein Aggregates to Form Mesoscale "smart" Hydrogels

Perovic, I., Davidyants, A. & Evans, J. S. Nov 30 2016 In : ACS Omega. 1, 5, p. 886-893 8 p.

Research output: Research - peer-reviewArticle

Nacre
Hydrogels
Calcium Carbonate
Hydrogel
Ions

A subset of CD4/CD8 double-negative T cells expresses HIV proteins in patients on antiretroviral therapy

DeMaster, L. K., Liu, X., VanBelzen, D. J., Trinité, B., Zheng, L., Agosto, L. M., Migueles, S. A., Connors, M., Sambucetti, L., Levy, D. N., Pasternak, A. O. & O'Doherty, U. 2016 In : Journal of Virology. 90, 5, p. 2165-2179 15 p.

Research output: Research - peer-reviewArticle

T-lymphocytes
therapeutics
proteins
cells
Human Immunodeficiency Virus Proteins

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

Angelova, P. R., Ludtmann, M. H. R., Horrocks, M. H., Negoda, A., Cremades, N., Klenerman, D., Dobson, C. M., Wood, N. W., Pavlov, E. V., Gandhi, S. & Abramov, A. Y. May 1 2016 In : Journal of Cell Science. 129, 9, p. 1792-1801 10 p.

Research output: Research - peer-reviewArticle

alpha-Synuclein
Cell Death
Artificial Membranes
Electrophysiology
Membranes

Ca2+ transport and signalling in enamel cells

Nurbaeva, M. K., Eckstein, M., Feske, S. & Lacruz, R. S. 2016 (Accepted/In press) In : Journal of Physiology.

Research output: Research - peer-reviewArticle

Ameloblasts
Dental Enamel
Enamel Organ
Vertebrates
Epithelial Cells

Contribution of inorganic polyphosphate towards regulation of mitochondrial free calcium

Solesio, M. E., Demirkhanyan, L., Zakharian, E. & Pavlov, E. V. Jun 1 2016 In : BBA - General Subjects. 1860, 6, p. 1317-1325 9 p.

Research output: Research - peer-reviewArticle

Polyphosphates
Calcium
Mitochondria
Phosphates
Calcium Signaling

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

Daniels, G., Zhang, X., Zhong, X., Santiago, L., Wang, L. H., Wu, X., Zhang, J. Y., Liang, F., Li, X., Neubert, T. A., Steinke, L., Shen, Y., Basch, R., Schneider, R., Levy, D. E. & Lee, P. 2016 In : Oncotarget. 7, 26, p. 39556-39571 16 p.

Research output: Research - peer-reviewArticle

Androgens
Prostatic Neoplasms
Apoptosis
Prostate
Amino Acids

DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH

Liu, Z., Kennedy, O. D., Cardoso, L., Basta-Pljakic, J., Partridge, N. C., Schaffler, M. B., Rosen, C. J. & Yakar, S. Feb 1 2016 In : FASEB Journal. 30, 2, p. 635-652 18 p.

Research output: Research - peer-reviewArticle

Parathyroid Hormone
Genetic Recombination
Bone and Bones
Genes
Bone

Does the GH/IGF-1 axis contribute to skeletal sexual dimorphism? Evidence from mouse studies

Liu, Z., Mohan, S. & Yakar, S. Apr 1 2016 In : Growth Hormone and IGF Research. 27, p. 7-17 11 p.

Research output: Research - peer-reviewArticle

Somatomedins
Sex Characteristics
Growth Hormone
Bone and Bones
Estrogen Receptors

Downregulation of proteinase-activated receptor-2, interleukin-17, and other proinflammatory genes by subantimicrobial doxycycline dose in a rat periodontitis model

Castro, M. L., Franco, G. C. N., Branco-De-almeida, L. S., Anbinder, A. L., Cogo-Müller, K., Cortelli, S. C., Duarte, S., Saxena, D. & Rosalen, P. L. Feb 1 2016 In : Journal of Periodontology. 87, 2, p. 203-210 8 p.

Research output: Research - peer-reviewArticle

PAR-2 Receptor
Interleukin-17
Doxycycline
Periodontitis
Down-Regulation

Editorial note

Peixoto, P. M., Pavlov, E. & Jonas, E. Oct 6 2016 (Accepted/In press) In : Journal of Bioenergetics and Biomembranes. p. 1-2 2 p.

Research output: Research - peer-reviewArticle

Effect of atmospheric-pressure cold plasma on pathogenic oral biofilms and in vitro reconstituted oral epithelium

Aparecida Delben, J., Evelin Zago, C., Tyhovych, N., Duarte, S. & Eduardo Vergani, C. May 1 2016 In : PLoS One. 11, 5, e0155427

Research output: Research - peer-reviewArticle

Plasma Gases
Atmospheric Pressure
Biofilms
Epithelium
In Vitro Techniques

Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells

Guttenplan, J. B., Chen, K. M., Sun, Y. W., Kosinska, W., Zhou, Y., Kim, S. A., Sung, Y., Gowda, K., Amin, S., Stoner, G. D. & El-Bayoumy, K. Aug 1 2016 In : Cancer Prevention Research. 9, 8, p. 704-712 9 p.

Research output: Research - peer-reviewArticle

DNA Adducts
Mutagenesis
Carcinogens
Oxidative Stress
Rubus

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Miles, B., Miller, S. M., Folkvord, J. M., Levy, D. N., Rakasz, E. G., Skinner, P. J. & Connick, E. Oct 1 2016 In : PLoS Pathogens. 12, 10, e1005924

Research output: Research - peer-reviewArticle

Germinal Center
Regulatory T-Lymphocytes
HIV Infections
T-Lymphocytes
HIV

Germinal center T follicular helper cells are highly permissive to HIV-1 and alter their phenotype during virus replication

Kohler, S. L., Pham, M. N., Folkvord, J. M., Arends, T., Miller, S. M., Miles, B., Meditz, A. L., McCarter, M., Levy, D. N. & Connick, E. Mar 15 2016 In : Journal of Immunology. 196, 6, p. 2711-2722 12 p.

Research output: Research - peer-reviewArticle

Germinal Center
Virus Replication
Helper-Inducer T-Lymphocytes
HIV-1
Phenotype

Growth hormone control of hepatic lipid metabolism

Liu, Z., Cordoba-Chacon, J., Kineman, R. D., Cronstein, B. N., Muzumdar, R., Gong, Z., Werner, H. & Yakar, S. Dec 1 2016 In : Diabetes. 65, 12, p. 3598-3609 12 p.

Research output: Research - peer-reviewArticle

Lipid Metabolism
Growth Hormone
Liver
Insulin-Like Growth Factor I
Lipids

Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging

Gong, Z., Tas, E., Yakar, S. & Muzumdar, R. May 3 2016 (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Research - peer-reviewArticle

Liver
Aging of materials
Lipid Metabolism
Non-alcoholic Fatty Liver Disease
Insulin

HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

Chan, C. N., Trinité, B., Lee, C. S., Mahajan, S., Anand, A., Wodarz, D., Sabbaj, S., Bansal, A., Goepfert, P. A. & Levy, D. N. Jan 5 2016 In : Retrovirology. 13, 1, 1

Research output: Research - peer-reviewArticle

Virus Latency
HIV-1
Genome
T-Lymphocytes
Infection

HIV-1 Vpr- and reverse transcription-induced apoptosis in resting peripheral blood CD4 T cells and protection by common gamma-chain cytokines

Trinité, B., Chan, C. N., Lee, C. S. & Levy, D. N. 2016 In : Journal of Virology. 90, 2, p. 904-916 13 p.

Research output: Research - peer-reviewArticle

Cytoprotection
Reverse Transcription
HIV-1
Apoptosis
Cytokines

Innate immunity in HIV-1 infection: Epithelial and non-specific host factors of mucosal immunity- a workshop report

Nittayananta, W., Weinberg, A., Malamud, D., Moyes, D., Webster-Cyriaque, J. & Ghosh, S. Apr 1 2016 In : Oral Diseases. 22, p. 171-180 10 p.

Research output: Research - peer-reviewArticle

Mucosal Immunity
Innate Immunity
HIV Infections
HIV-1
Education

Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore

Solesio, M. E., Elustondo, P. A., Zakharian, E. & Pavlov, E. V. Feb 15 2016 In : Biochemical Society Transactions. 44, p. 7-12 6 p.

Research output: Research - peer-reviewArticle

Polyphosphates
mitochondrial permeability transition pore
Chemical activation
Calcium
Membranes