Andrew Hamilton

President

1977 …2019
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Farnesyltranstransferase Medicine & Life Sciences
Artificial Receptors Chemical Compounds
Scaffolds Chemical Compounds
Hydrogen bonds Chemical Compounds
Prenylation Medicine & Life Sciences
Peptidomimetics Medicine & Life Sciences
Molecular recognition Chemical Compounds
Proteins Chemical Compounds

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Research Output 1977 2019

Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors

Kazi, A., Xiang, S., Yang, H., Chen, L., Kennedy, P., Ayaz, M., Fletcher, S., Cummings, C., Lawrence, H. R., Beato, F., Kang, Y., Kim, M. P., Delitto, A., Underwood, P. W., Fleming, J. B., Trevino, J. G., Hamilton, A. & Sebti, S. M., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5984-5996 13 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Transferases
Pancreatic Neoplasms
Heterografts
Prenylation

Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers

Meisel, J. W., Hu, C. T. & Hamilton, A. D., Oct 4 2019, In : Organic Letters. 21, 19, p. 7763-7767 5 p.

Research output: Contribution to journalArticle

Open Access
Functional groups
Bearings (structural)
Artificial Receptors
Molecular recognition
Solid-Phase Synthesis Techniques

α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA

Maity, D., Kumar, S., Curreli, F., Debnath, A. K. & Hamilton, A., Jan 1 2019, In : Chemistry - A European Journal.

Research output: Contribution to journalArticle

RNA
Proteins
Scaffolds (biology)
Scaffolds
Conformations

Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin

Lee, C. H., Yu, J. R., Kumar, S., Jin, Y., LeRoy, G., Bhanu, N., Kaneko, S., Garcia, B. A., Hamilton, A. & Reinberg, D., Jan 1 2018, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Chromatin
Mutation
Personnel Selection
Neoplasms
Clinical Trials

Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer

Meisel, J. W., Hu, C. T. & Hamilton, A., Jul 6 2018, In : Organic Letters. 20, 13, p. 3879-3882 4 p.

Research output: Contribution to journalArticle

Scaffolds
Conformations
Hydrogen
Hydrogen bonds
flexibility