David Scicchitano

2018

Genetic instability associated with loop or stem-loop structures within transcription units can be independent of nucleotide excision repair

Burns, J. A., Chowdhury, M. A., Cartularo, L., Berens, C. & Scicchitano, D. A., Mar 1 2018, In: Nucleic acids research. 46, 7, p. 3498-3516 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

O⁶-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function

Ezerskyte, M., Paredes, J. A., Malvezzi, S., Burns, J. A., Margison, G. P., Olsson, M., Scicchitano, D. A. & Dreij, K., May 1 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4731-4736 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro

Kolbanovskiy, M., Chowdhury, M. A., Nadkarni, A., Broyde, S., Geacintov, N. E., Scicchitano, D. A. & Shafirovich, V., Jun 20 2017, In: Biochemistry. 56, 24, p. 3008-3018 11 p.

Research output: Contribution to journal › Article › peer-review

2016

Nucleotide excision repair and transcription-coupled DNA repair abrogate the impact of DNA damage on transcription

Nadkarni, A., Burns, J. A., Gandolfi, A., Chowdhury, M. A., Cartularo, L., Berens, C., Geacintov, N. E. & Scicchitano, D. A., Jan 8 2016, In: Journal of Biological Chemistry. 291, 2, p. 848-861 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway

Dreij, K., Rhrissorrakrai, K., Gunsalus, K. C., Geacintov, N. E. & Scicchitano, D. A., Apr 9 2010, In: Carcinogenesis. 31, 6, p. 1149-1157 9 p.

Research output: Contribution to journal › Article › peer-review

O⁶-Methylguanine induces altered proteins at the level of transcription in human cells

Burns, J. A., Dreij, K., Cartularo, L. & Scicchitano, D. A., Dec 2010, In: Nucleic acids research. 38, 22, p. 8178-8187 10 p.

Research output: Contribution to journal › Article › peer-review

2008

Transcription elongation past O⁶-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase

Dimitri, A., Burns, J. A., Broyde, S. & Scicchitano, D. A., 2008, In: Nucleic acids research. 36, 20, p. 6459-6471 13 p.

Research output: Contribution to journal › Article › peer-review

Transcription of DNA containing the 5-guanidino-4-nitroimidazole lesion by human RNA polymerase II and bacteriophage T7 RNA polymerase

Dimitri, A., Jia, L., Shafirovich, V., Geacintov, N. E., Broyde, S. & Scicchitano, D. A., Aug 2 2008, In: DNA Repair. 7, 8, p. 1276-1288 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcription Processing at 1,N²-Ethenoguanine by Human RNA Polymerase II and Bacteriophage T7 RNA Polymerase

Dimitri, A., Goodenough, A. K., Guengerich, F. P., Broyde, S. & Scicchitano, D. A., Jan 11 2008, In: Journal of Molecular Biology. 375, 2, p. 353-366 14 p.

Research output: Contribution to journal › Article › peer-review

2007

Increased flexibility enhances misincorporation: Temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase

Perlow-Poehnelt, R. A., Likhterov, I., Wang, L., Scicchitano, D. A., Geacintov, N. E. & Broyde, S., Jan 12 2007, In: Journal of Biological Chemistry. 282, 2, p. 1397-1408 12 p.

Research output: Contribution to journal › Article › peer-review

2004

The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: Elucidating the structure-function relationship through experimental and computational approaches

Perlow-Poehnelt, R. A., Likhterov, I., Scicchitano, D. A., Geacintov, N. E. & Broyde, S., Aug 27 2004, In: Journal of Biological Chemistry. 279, 35, p. 36951-36961 11 p.

Research output: Contribution to journal › Article › peer-review

2003

Construction and purification of site-specifically modified DNA templates for transcription assays.

Perlow, R. A., Schinecker, T. M., Kim, S. J., Geacintov, N. E. & Scicchitano, D. A., Apr 1 2003, In: Nucleic acids research. 31, 7, p. e40

Research output: Contribution to journal › Article › peer-review

Open Access

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: Relating biological consequences to conformational preferences

Schinecker, T. M., Perlow, R. A., Broyde, S., Geacintov, N. E. & Scicchitano, D. A., Oct 15 2003, In: Nucleic acids research. 31, 20, p. 6004-6015 12 p.

Research output: Contribution to journal › Article › peer-review

2002

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

Plosky, B., Samson, L., Engelward, B. P., Gold, B., Schlaen, B., Millas, T., Magnotti, M., Schor, J. & Scicchitano, D. A., Aug 6 2002, In: DNA Repair. 1, 8, p. 683-696 14 p.

Research output: Contribution to journal › Article › peer-review

DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner

Perlow, R. A., Kolbanovskii, A., Hingerty, B. E., Geacintov, N. E., Broyde, S. & Scicchitano, D. A., 2002, In: Journal of Molecular Biology. 321, 1, p. 29-47 19 p.

Research output: Contribution to journal › Article › peer-review

2001

Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions

Roth, R. B., Amin, S., Geacintov, N. E. & Scicchitano, D. A., May 1 2001, In: Biochemistry. 40, 17, p. 5200-5207 8 p.

Research output: Contribution to journal › Article › peer-review

1997

Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells

Sitaram, A., Plitas, G., Wang, W. & Scicchitano, D. A., Feb 1997, In: Molecular and cellular biology. 17, 2, p. 564-570 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1995

3-Methyladenine and 7-Methylguanine Exhibit No Preferential Removal from the Transcribed Strand of the Dihydrofolate Reductase Gene in Chinese Hamster Ovary B11 Cells

Wang, W., Sitaram, A. & Scicchitano, D. A., Feb 1995, In: Biochemistry. 34, 5, p. 1798-1804 7 p.

Research output: Contribution to journal › Article › peer-review

1994

Site-Specific Benzo[a]pyrene Diol Epoxide-DNA Adducts Inhibit Transcription Elongation by Bacteriophage T7 RNA Polymerase

Choi, D. J., Marino-Alessandri, D. J., Geacintov, N. E. & Scicchitano, D. A., Jan 1 1994, In: Biochemistry. 33, 3, p. 780-787 8 p.

Research output: Contribution to journal › Article › peer-review

1992

Intragenomic repair heterogeneity of DNA damage

Scicchitano, D. A. & Hanawalt, P. C., 1992, In: Environmental health perspectives. 98, p. 45-51 7 p.

Research output: Contribution to journal › Article › peer-review

1991

Two expressed human genes sustain slightly more DNA damage after alkylating agent treatment than an inactive gene

Bartlett, J. D., Scicchitano, D. A. & Robison, S. H., Nov 1991, In: Mutation Research-DNA Repair. 255, 3, p. 247-256 10 p.

Research output: Contribution to journal › Article › peer-review

1990

Lack of sequence-specific removal of N-methylpurines from cellular DNA

Scicchitano, D. A. & Hanawalt, P. C., 1990, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 233, 1-2, p. 31-37 7 p.

Research output: Contribution to journal › Article › peer-review

Measurements of genomic and gene-specific DNA repair of alkylation damage in cultured human T-lymphocytes.

Hartshorn, J. N., Scicchitano, D. A. & Robison, S. H., 1990, In: Basic life sciences. 53, p. 233-249 17 p.

Research output: Contribution to journal › Article › peer-review

1989

Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: Absence of strand specificity in the dihydrofolate reductase gene

Scicchitano, D. A. & Hanawalt, P. C., 1989, In: Proceedings of the National Academy of Sciences of the United States of America. 86, 9, p. 3050-3054 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1988

Use of oligodeoxynucleotides containing o⁶-alkylguanine for the assay of o⁶-alkylguanine-dna-alkyl transferase activity

Dolan, M. E., Schicchitiano, D. & Pegg, A. E., Mar 1988, In: Cancer Research. 48, 5, p. 1184-1188 5 p.

Research output: Contribution to journal › Article › peer-review

1987

Inhibition of O⁶-alkylguanine-DNA-alkyltransferase by metals

Scicchitano, D. A. & Pegg, A. E., Nov 1987, In: Mutation Research Letters. 192, 3, p. 207-210 4 p.

Research output: Contribution to journal › Article › peer-review

Specificity of O6-alkylguanine-DNA alkyltransferase.

Pegg, A. E., Scicchitano, D., Morimoto, K. & Dolan, M. E., 1987, In: IARC scientific publications. 84, p. 30-34 5 p.

Research output: Contribution to journal › Article › peer-review

1986

Repair of oligodeoxynucleotides containing o-methylguanine by o-alkylguanine-dna-alkyltransferase

Scicchitano, D., Jones, R. A., Kuzmich, S., Gaffney, B., Lasko, D. D., Essigmann, J. M. & Pegg, A. E., 1986, In: Carcinogenesis. 7, 8, p. 1383-1386 4 p.

Research output: Contribution to journal › Article › peer-review

1985

Repair of o-propylguanine and o-butylguanine in dna by o-alkylguanine-dna alkyltransferases from rat liver and E. coli

Morimoto, K., Dolan, M. E., Scicchitano, D. & Pegg, A. E., Jul 1985, In: Carcinogenesis. 6, 7, p. 1027-1031 5 p.

Research output: Contribution to journal › Article › peer-review

Studies of the repair of O⁶-alkylguanine and O⁴-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria

Pegg, A. E., Dolan, M. E., Scicchitano, D. & Morimoto, K., 1985, In: Environmental health perspectives. VOL. 62, p. 109-114 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1984

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

Dolan, M. E., Scicchitano, D., Singer, B. & Pegg, A. E., Aug 30 1984, In: Biochemical and Biophysical Research Communications. 123, 1, p. 324-330 7 p.

Research output: Contribution to journal › Article › peer-review

Comparison of the Rates off Repair off O6-Alkylguanines in DNA by Rat Liver and Bacterial O6-Alkylguanine-DNA Alkyltransferase

Pegg, A. E., Scicchitano, D. & Dolan, M. E., Sep 1 1984, In: Cancer Research. 44, 9, p. 3806-3811 6 p.

Research output: Contribution to journal › Article › peer-review

1982

Kinetics of repair of O⁶-methylguanine in DNA by O⁶-methylguanine-DNA methyltransferase in, vitro and in, vivo

Scicchitano, D. & Pegg, A. E., Dec 15 1982, In: Biochemical and Biophysical Research Communications. 109, 3, p. 995-1001 7 p.

Research output: Contribution to journal › Article › peer-review

David Scicchitano

Research output

Search results