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Elodie Ghedin

Professor of Biology and Public Health

    1993 …2020

    Research output per year

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    Research Output

    A2rel: a constitutively expressed Leishmania gene linked to an amastigote-stage-specific gene

    Ghedin, E., Charest, H. & Matlashewski, G., May 15 1998, In : Molecular and Biochemical Parasitology. 93, 1, p. 23-29 7 p.

    Research output: Contribution to journalArticle

    A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, brugia malayi

    Choi, Y. J., Ghedin, E., Berriman, M., McQuillan, J., Holroyd, N., Mayhew, G. F., Christensen, B. M. & Michalski, M. L., Dec 2011, In : PLoS neglected tropical diseases. 5, 12, e1409.

    Research output: Contribution to journalArticle

    A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling

    Guiliano, D. B., Hong, X., McKerrow, J. H., Blaxter, M. L., Oksov, Y., Liu, J., Ghedin, E. & Lustigman, S., Aug 2004, In : Molecular and Biochemical Parasitology. 136, 2, p. 227-242 16 p.

    Research output: Contribution to journalArticle

    Age-Related Pathology Associated with H1N1 A/California/07/2009 Influenza Virus Infection

    Bissel, S. J., Carter, C. E., Wang, G., Johnson, S. K., Lashua, L. P., Kelvin, A. A., Wiley, C. A., Ghedin, E. & Ross, T. M., Dec 2019, In : American Journal of Pathology. 189, 12, p. 2389-2399 11 p.

    Research output: Contribution to journalArticle

    A large-scale immuno-epidemiological simulation of influenza A epidemics

    Lukens, S., Depasse, J., Rosenfeld, R., Ghedin, E., Mochan, E., Brown, S. T., Grefenstette, J., Burke, D. S., Swigon, D. & Clermont, G., Sep 29 2014, In : BMC public health. 14, 1, 1019.

    Research output: Contribution to journalArticle

    A multi-reservoir model of influenza evolution

    Dreisigmeyer, D. W., Rosenfeld, R., DePasse, J. V., Ghedin, E., Price, I. & Clermont, G., 2009, In : J Crit Care. 24, 3, p. e33-e34

    Research output: Contribution to journalArticle

    Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi

    Liu, C., Kelen, P. V., Ghedin, E., Lustigman, S. & Unnasch, T. R., Dec 2011, In : Molecular and Biochemical Parasitology. 180, 2, p. 106-111 6 p.

    Research output: Contribution to journalArticle

    Antibody response against a Leishmania donovani amastigote-stage-specific protein in patients with visceral leishmaniasis

    Ghedin, E., Zhang, W. W., Charest, H., Sundar, S., Kenney, R. T. & Matlashewski, G., Sep 1997, In : Clinical and Diagnostic Laboratory Immunology. 4, 5, p. 530-535 6 p.

    Research output: Contribution to journalArticle

    A Potential Role for the Interaction of Wolbachia Surface Proteins with the Brugia malayi Glycolytic Enzymes and Cytoskeleton in Maintenance of Endosymbiosis

    Melnikow, E., Xu, S., Liu, J., Bell, A. J., Ghedin, E., Unnasch, T. R. & Lustigman, S., Apr 2013, In : PLoS neglected tropical diseases. 7, 4, e2151.

    Research output: Contribution to journalArticle

    A rapid and label-free platform for virus capture and identification from clinical samples

    Yeh, Y. T., Gulino, K., Zhang, Y. H., Sabestien, A., Chou, T. W., Zhou, B., Lin, Z., Albert, I., Lu, H., Swaminathan, V., Ghedin, E. & Terrones, M., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 895-901 7 p.

    Research output: Contribution to journalArticle

    Open Access

    Arboretum and Puerto Almendras viruses: Two novel rhabdoviruses isolated from mosquitoes in Peru

    Vasilakis, N., Castro-Llanos, F., Widen, S. G., Aguilar, P. V., Guzman, H., Guevara, C., Fernandez, R., Auguste, A. J., Wood, T. G., Popov, V., Mundal, K., Ghedin, E., Kochel, T. J., Holmes, E. C., Walker, P. J. & Tesh, R. B., 2014, In : Journal of General Virology. 95, PART 4, p. 787-792 6 p.

    Research output: Contribution to journalArticle

    A virus with big ambitions

    Ghedin, E. & Fraser, C. M., Feb 2005, In : Trends in Microbiology. 13, 2, p. 56-57 2 p.

    Research output: Contribution to journalShort survey

    Biologic, antigenic, and full-length genomic characterization of a bovine-like coronavirus isolated from a giraffe

    Hasoksuz, M., Alekseev, K., Vlasova, A., Zhang, X., Spiro, D., Halpin, R., Wang, S., Ghedin, E. & Saif, L. J., May 2007, In : Journal of virology. 81, 10, p. 4981-4990 10 p.

    Research output: Contribution to journalArticle

    Bovine-like coronaviruses isolated from four species of captive wild ruminants are homologous to bovine coronaviruses, based on complete genomic sequences

    Alekseev, K. P., Vlasova, A. N., Jung, K., Hasoksuz, M., Zhang, X., Halpin, R., Wang, S., Ghedin, E., Spiro, D. & Saif, L. J., Dec 2008, In : Journal of virology. 82, 24, p. 12422-12431 10 p.

    Research output: Contribution to journalArticle

    Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment

    Ghedin, E., Hailemariam, T., DePasse, J. V., Zhang, X., Oksov, Y., Unnasch, T. R. & Lustigman, S., Oct 2009, PLoS Neglected Tropical Diseases. 10 ed. Vol. 3. e525

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cell-to-cell variation in defective virus expression and effects on host responses during influenza virus infection

    Wang, C., Forst, C. V., Chou, T. W., Geber, A., Wang, M., Hamou, W., Smith, M., Sebra, R., Zhang, B., Zhou, B. & Ghedin, E., Jan 1 2020, In : mBio. 11, 1, e02880-19.

    Research output: Contribution to journalArticle

    Open Access

    Characterization of antibiotic resistance and host-microbiome interactions in the human upper respiratory tract during influenza infection

    Zhang, L., Forst, C. V., Gordon, A., Gussin, G., Geber, A. B., Fernandez, P. J., Ding, T., Lashua, L., Wang, M., Balmaseda, A., Bonneau, R., Zhang, B. & Ghedin, E., Mar 17 2020, In : Microbiome. 8, 1, 39.

    Research output: Contribution to journalArticle

    Open Access

    Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas

    Rogers, M. B., Gulino, K. M., Tesh, R. B., Cui, L., Fitch, A., Unnasch, T. R., Popov, V. L., Travassos da Rosa, A. P. A., Guzman, H., Carrera, J. P., Vasilakis, N. & Ghedin, E., Sep 2017, In : Journal of General Virology. 98, 9, p. 2258-2266 9 p., 000899.

    Research output: Contribution to journalArticle

    Comparative analysis of the complete genome sequence of the california msw strain of myxoma virus reveals potential host adaptations

    Kerr, P. J., Rogers, M. B., Fitch, A., DePasse, J. V., Cattadori, I. M., Hudson, P. J., Tscharke, D. C., Holmes, E. C. & Ghedin, E., 2013, In : Journal of virology. 87, 22, p. 12080-12089 10 p.

    Research output: Contribution to journalArticle

    Comparative genomics of trypanosomatid parasitic protozoa

    El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E., Renauld, H., Worthey, E. A., Hertz-Fowler, C., Ghedin, E., Peacock, C., Bartholomeu, D. C., Haas, B. J., Tran, A. N., Wortman, J. R., Alsmark, U. C. M., Angiuoli, S., Anupama, A., Badger, J. & 25 others, Bringaud, F., Cadag, E., Carlton, J. M., Cerqueira, G. C., Creasy, T., Delcher, A. L., Djikeng, A., Embley, T. M., Hauser, C., Ivens, A. C., Kummerfeld, S. K., Pereira-Leal, J. B., Nilsson, D., Peterson, J., Salzberg, S. L., Shallom, J., Silva, J. C., Sundaram, J., Westenberger, S., White, O., Melville, S. E., Donelson, J. E., Andersson, B., Stuart, K. D. & Hall, N., Jul 15 2005, In : Science. 309, 5733, p. 404-409+435

    Research output: Contribution to journalArticle

    Comparison of the nasopharynx microbiome between influenza and non-influenza cases of severe acute respiratory infections: A pilot study

    Borges, L. G. D. A., Giongo, A., Pereira, L. D. M., Trindade, F. J., Gregianini, T. S., Campos, F. S., Ghedin, E. & da Veiga, A. B. G., Jun 1 2018, In : Health Science Reports. 1, 6, e47.

    Research output: Contribution to journalArticle

    Open Access

    Comparison of the respiratory microbiome in healthy nonsmokers and smokers

    Morris, A., Beck, J. M., Schloss, P. D., Campbell, T. B., Crothers, K., Curtis, J. L., Flores, S. C., Fontenot, A. P., Ghedin, E., Huang, L., Jablonski, K., Kleerup, E., Lynch, S. V., Sodergren, E., Twigg, H., Young, V. B., Bassis, C. M., Venkataraman, A., Schmidt, T. M. & Weinstock, G. M., May 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 10, p. 1067-1075 9 p.

    Research output: Contribution to journalArticle

    Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus

    Zhang, X., Hasoksuz, M., Spiro, D., Halpin, R., Wang, S., Stollar, S., Janies, D., Hadya, N., Tang, Y., Ghedin, E. & Saif, L., Feb 20 2007, In : Virology. 358, 2, p. 424-435 12 p.

    Research output: Contribution to journalArticle

    Correction: Transmission bottleneck size estimation from pathogen deep-sequencing data, with an application to human influenza A virus (Journal of Virology (2017) 91:14 (e00171-17) DOI: 10.1128/JVI.00171-17)

    Leonard, A. S., Weissman, D. B., Greenbaum, B., Ghedin, E. & Koelle, K., Sep 1 2019, In : Journal of virology. 93, 17, e00936-19.

    Research output: Contribution to journalComment/debate

    Open Access

    Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection

    Cribbs, S. K., Uppal, K., Li, S., Jones, D. P., Huang, L., Tipton, L., Fitch, A., Greenblatt, R. M., Kingsley, L., Guidot, D. M., Ghedin, E. & Morris, A., Dec 1 2016, In : Microbiome. 4, 1

    Research output: Contribution to journalArticle

    Cyclic avian mass mortality in the northeastern United States is associated with a novel orthomyxovirus

    Allison, A. B., Ballard, J. R., Tesh, R. B., Brown, J. D., Ruder, M. G., Keel, M. K., Munk, B. A., Mickley, R. M., Gibbs, S. E. J., Travassos da Rosa, A. P. A., Ellis, J. C., Ip, H. S., Shearn-Bochsler, V. I., Rogers, M. B., Ghedin, E., Holmes, E. C., Parrish, C. R. & Dwyer, C., 2015, In : Journal of virology. 89, 2, p. 1389-1403 15 p.

    Research output: Contribution to journalArticle

    Deep sequencing reveals mixed infection with 2009 pandemic influenza A (H1N1) virus strains and the emergence of oseltamivir resistance

    Ghedin, E., Laplante, J., DePasse, J., Wentworth, D. E., Santos, R. P., Lepow, M. L., Porter, J., Stellrecht, K., Lin, X., Operario, D., Griesemer, S., Fitch, A., Halpin, R. A., Stockwell, T. B., Spiro, D. J., Holmes, E. C. & St George, K., Jan 15 2011, In : Journal of Infectious Diseases. 203, 2, p. 168-174 7 p.

    Research output: Contribution to journalArticle

    Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq

    Grote, A., Voronin, D., Ding, T., Twaddle, A., Unnasch, T. R., Lustigman, S. & Ghedin, E., Mar 30 2017, In : PLoS neglected tropical diseases. 11, 3, e0005357.

    Research output: Contribution to journalArticle

    Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

    Gardner, C. L., Hritz, J., Sun, C., Vanlandingham, D. L., Song, T. Y., Ghedin, E., Higgs, S., Klimstra, W. B. & Ryman, K. D., Feb 2014, In : PLoS neglected tropical diseases. 8, 2, e2719.

    Research output: Contribution to journalArticle

    Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis.

    Yao, K., Akyani, N., Donati, D., Sengamalay, N., Fotheringham, J., Ghedin, E., Bishop, M., Barrett, J., Kashanchi, F. & Jacobson, S., Dec 2006, In : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 37 Suppl 1, p. S57-62

    Research output: Contribution to journalArticle

    Development and characterization of a reverse-genetics system for influenza D virus

    Yu, J., Liu, R., Zhou, B., Chou, T. W., Ghedin, E., Sheng, Z., Gao, R., Zhai, S. L., Wang, D. & Lia, F., 2019, In : Journal of virology. 93, 21, e01186-19.

    Research output: Contribution to journalArticle

    Development of high-yield influenza A virus vaccine viruses

    Ping, J., Lopes, T. J. S., Nidom, C. A., Ghedin, E., MacKen, C. A., Fitch, A., Imai, M., Maher, E. A., Neumann, G. & Kawaoka, Y., Sep 2 2015, In : Nature communications. 6, 8148.

    Research output: Contribution to journalArticle

    Differential HHV-6A gene expression in T Cells and primary human astrocytes based on multi-virus array analysis

    Yao, K., Mandel, M., Akyani, N., Maynard, K., Sengamalay, N., Fotheringham, J., Ghedin, E., Kashanchi, F. & Jacobson, S., Jun 2006, In : GLIA. 53, 8, p. 789-798 10 p.

    Research output: Contribution to journalArticle

    Dissection of the functional domains of the Leishmania surface membrane 3'-nucleotidase/nuclease, a unique member of the class I nuclease family

    Debrabant, A., Ghedin, E. & Dwyer, D. M., May 26 2000, In : Journal of Biological Chemistry. 275, 21, p. 16366-16372 7 p.

    Research output: Contribution to journalArticle

    Draft genome of the filarial nematode parasite Brugia malayi

    Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M. & 51 others, Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, M., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B. W., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrín-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L. & Scott, A. L., Sep 21 2007, In : Science. 317, 5845, p. 1756-1760 5 p.

    Research output: Contribution to journalArticle

    Draft genome of the filarial nematode parasite Brugia malayi (Science (2007) (1756))

    Ghedin, E., Anton, B. P. & White, O., Jan 2 2009, In : Science. 323, 5910, 1 p.

    Research output: Contribution to journalComment/debate

    Emerging and resistant infections

    Clancy, C. J., Kalil, A. C., Fowler, V. G., Ghedin, E., Kolls, J. K. & Nguyen, M. H., Aug 1 2014, In : Annals of the American Thoracic Society. 11, p. S193-S200

    Research output: Contribution to journalArticle

    Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

    Segal, L. N., Clemente, J. C., Tsay, J. J., Koralov, S. B., Keller, B. C., Wu, B. G., Li, Y., Shen, N., Ghedin, E., Morris, A., Diaz, P., Huang, L., Wikoff, W. R., Ubeda, C., Artacho, A., Rom, W. N., Sterman, D. H., Collman, R. G., Blaser, M. J. & Weiden, M. D., 2016, In : Nature Reviews Microbiology. 1, 5

    Research output: Contribution to journalArticle

    Erratum: Stochastic processes are key determinants of short-term evolution in influenza A virus (PLoS pathogens 2, 12 DOI: 10.1371/journal.ppat.0020125)

    Nelson, M. I., Simonsen, L., Viboud, C., Miller, M. A., Taylor, J., St. George, K., Griesemer, S. B., Ghedin, E., Sengamalay, N. A., Spiro, D. J., Volkov, I., Grenfell, B. T., Lipman, D. J., Taubenberger, J. K. & Holmes, E. C., Dec 2006, In : PLoS Pathogens. 2, 12, 1 p.

    Research output: Contribution to journalComment/debate

    Evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses

    Hackenbrack, N., Rogers, M. B., Ashley, R. E., Keel, M. K., Kubiski, S. V., Bryan, J. A., Ghedin, E., Holmes, E. C., Hafenstein, S. L. & Allison, A. B., 2017, In : Journal of virology. 91, 2, e01504-16.

    Research output: Contribution to journalArticle

    Evolutionary History and Attenuation of Myxoma Virus on Two Continents

    Kerr, P. J., Ghedin, E., DePasse, J. V., Fitch, A., Cattadori, I. M., Hudson, P. J., Tscharke, D. C., Read, A. F. & Holmes, E. C., Oct 2012, In : PLoS Pathogens. 8, 10, e1002950.

    Research output: Contribution to journalArticle

    Evolution of influenza B virus in Kuala Lumpur, Malaysia, between 1995 and 2008

    Sam, I. C., Su, Y. C. F., Chan, Y. F., Nor'E, S. S., Hassan, A., Jafar, F. L., Joseph, U., Halpin, R. A., Ghedin, E., Hooi, P. S., Fourment, M., Hassan, H., AbuBakar, S., Wentworth, D. E. & Smith, G. J. D., 2015, In : Journal of virology. 89, 18, p. 9689-9692 4 p.

    Research output: Contribution to journalArticle

    Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements

    Bringaud, F., Ghedin, E., Blandin, G., Bartholomeu, D. C., Caler, E., Levin, M. J., Baltz, T. & El-Sayed, N. M., Feb 2006, In : Molecular and Biochemical Parasitology. 145, 2, p. 158-170 13 p.

    Research output: Contribution to journalArticle

    Extensive geographical mixing of 2009 human H1N1 influenza a virus in a single university community

    Holmes, E. C., Ghedin, E., Halpin, R. A., Stockwell, T. B., Zhang, X. Q., Fleming, R., Davey, R., Benson, C. A., Mehta, S., Taplitz, R., Liu, Y. T., Brouwer, K. C., Wentworth, D. E., Lin, X. & Schooley, R. T., Jul 2011, In : Journal of virology. 85, 14, p. 6923-6929 7 p.

    Research output: Contribution to journalArticle

    Filarial and Wolbachia genomics

    Scott, A. L., Ghedin, E., Nutman, T. B., McReynolds, L. A., Poole, C. B., Slatko, B. E. & Foster, J. M., Feb 2012, In : Parasite Immunology. 34, 2-3, p. 121-129 9 p.

    Research output: Contribution to journalReview article

    First sequenced genome of a parasitic nematode

    Ghedin, E., Wang, S., Foster, J. M. & Slatko, B. E., Apr 2004, In : Trends in Parasitology. 20, 4, p. 151-153 3 p.

    Research output: Contribution to journalShort survey

    Functional analysis of microRNA activity in Brugia malayi

    Liu, C., Voronin, D., Poole, C. B., Bachu, S., Rogers, M. B., Jin, J., Ghedin, E., Lustigman, S., McReynolds, L. A. & Unnasch, T. R., Aug 1 2015, In : International Journal for Parasitology. 45, 9-10, p. 579-583 5 p.

    Research output: Contribution to journalArticle

    Functional analysis of putative operons in Brugia malayi

    Liu, C., Oliveira, A., Chauhan, C., Ghedin, E. & Unnasch, T. R., Jan 2010, In : International Journal for Parasitology. 40, 1, p. 63-71 9 p.

    Research output: Contribution to journalArticle

    Fungi stabilize connectivity in the lung and skin microbial ecosystems

    Tipton, L., Müller, C. L., Kurtz, Z. D., Huang, L., Kleerup, E., Morris, A., Bonneau, R. & Ghedin, E., 2018, In : Microbiome. 6, 1, 12.

    Research output: Contribution to journalArticle