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Eric Klann

Professor of Neural Science

    1989 …2020

    Research output per year

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    Research Output

    2020

    Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

    Shrestha, P., Ayata, P., Herrero-Vidal, P., Longo, F., Gastone, A., LeDoux, J. E., Heintz, N. & Klann, E., Feb 1 2020, In : Nature Neuroscience. 23, 2, p. 281-292 12 p.

    Research output: Contribution to journalArticle

    Interactions between sleep disruption, motor learning, and p70 S6 kinase 1 signaling

    Kam, K., Kang, M., Eren, C. Y., Pettibone, W. D., Bowling, H., Taveras, S., Ly, A., Chen, R. K., Berryman, N. V., Klann, E. & Varga, A. W., Mar 12 2020, In : Sleep. 43, 3

    Research output: Contribution to journalArticle

    N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

    Venkatasubramani, J. P., Subramanyam, P., Pal, R., Reddy, B. K., Srinivasan, D. J., Chattarji, S., Iossifov, I., Klann, E. & Bhattacharya, A., May 2020, In : Neurobiology of Learning and Memory. 171, 107203.

    Research output: Contribution to journalArticle

    Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB

    Young-Baird, S. K., Lourenço, M. B., Elder, M. K., Klann, E., Liebau, S. & Dever, T. E., Feb 20 2020, In : Molecular Cell. 77, 4, p. 875-886.e7

    Research output: Contribution to journalArticle

    2019

    Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

    Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T. A. & Klann, E., Dec 1 2019, In : Nature communications. 10, 1, 1710.

    Research output: Contribution to journalArticle

    Open Access

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

    Ostroff, L. E., Santini, E., Sears, R., Deane, Z., Kanadia, R. N., Ledoux, J. E., Lhakhang, T., Tsirigos, A., Heguy, A. & Klann, E., Dec 2019, In : eLife. 8, e51607.

    Research output: Contribution to journalArticle

    Open Access

    Inositol polyphosphate multikinase mediates extinction of fear memory

    Park, J., Longo, F., Park, S. J., Lee, S., Bae, M., Tyagi, R., Han, J. H., Kim, S., Santini, E., Klann, E. & Snyder, S. H., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2707-2712 6 p.

    Research output: Contribution to journalArticle

    Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

    Gross, C., Banerjee, A., Tiwari, D., Longo, F., White, A. R., Allen, A. G., Schroeder-Carter, L. M., Krzeski, J. C., Elsayed, N. A., Puckett, R., Klann, E., Rivero, R. A., Gourley, S. L. & Bassell, G. J., Jan 1 2019, In : Neuropsychopharmacology. 44, 2, p. 324-333 10 p.

    Research output: Contribution to journalArticle

    Proteomic Tools to Study the Effect of BDNF on De Novo Protein Synthesis

    Bowling, H. & Klann, E., 2019, Neuromethods. Humana Press Inc., p. 217-239 23 p. (Neuromethods; vol. 143).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Translating from cancer to the brain: Regulation of protein synthesis by eIF4F

    Kats, I. R. & Klann, E., 2019, In : Learning and Memory. 26, 9, p. 332-342 11 p.

    Research output: Contribution to journalReview article

    Open Access

    UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function

    Notaras, M., Allen, M., Longo, F., Volk, N., Toth, M., Li Jeon, N., Klann, E. & Colak, D., 2019, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    2018

    Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

    Huynh, T. N., Santini, E., Mojica, E., Fink, A. E., Hall, B. S., Fetcho, R. N., Grosenick, L., Deisseroth, K., Ledoux, J. E., Liston, C. & Klann, E., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1394-1401 8 p.

    Research output: Contribution to journalArticle

    Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala

    Huynh, T. N., Santini, E., Mojica, E., Fink, A. E., Hall, B. S., Fetcho, R. N., Grosenick, L., Deisseroth, K., Ledoux, J. E., Liston, C. & Klann, E., Jun 1 2018, In : Molecular Psychiatry. 23, 6, 1 p.

    Research output: Contribution to journalComment/debate

    The mouse as a model for neuropsychiatric drug development

    Howe, J. R., Bear, M. F., Golshani, P., Klann, E., Lipton, S. A., Mucke, L., Sahin, M. & Silva, A. J., Sep 10 2018, In : Current Biology. 28, 17, p. R909-R914

    Research output: Contribution to journalComment/debate

    Turning up translation in fragile X syndrome

    Aryal, S. & Klann, E., Aug 17 2018, In : Science. 361, 6403, p. 648-649 2 p.

    Research output: Contribution to journalShort survey

    2017

    Accumulation of polyribosomes in dendritic spine heads, but not bases and necks, during memory consolidation depends on cap-dependent translation initiation

    Ostroff, L. E., Botsford, B., Gindina, S., Cowansage, K. K., Ledoux, J. E., Klann, E. & Hoeffer, C., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1862-1872 11 p.

    Research output: Contribution to journalArticle

    CC2D1a loss of function disrupts functional and morphological development in forebrain neurons leading to cognitive and social deficits

    Oaks, A. W., Zamarbide, M., Tambunan, D. E., Santini, E., Costanzo, S. D., Pond, H. L., Johnson, M. W., Lin, J., Gonzalez, D. M., Boehler, J. F., Wu, G. K., Klann, E., Walsh, C. A. & Chiara Manzini, M., 2017, In : Cerebral Cortex. 27, 2, p. 1670-1685 16 p.

    Research output: Contribution to journalArticle

    Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

    Santini, E., Huynh, T. N., Longo, F., Koo, S. Y., Mojica, E., D'Andrea, L., Bagni, C. & Klann, E., Nov 7 2017, In : Science signaling. 10, 504, eaan0665.

    Research output: Contribution to journalArticle

    Translational Control Mechanisms in Synaptic Plasticity and Memory

    Costa-Mattioli, M. & Klann, E., Jan 1 2017, Learning and Memory: A Comprehensive Reference. Elsevier Inc., p. 311-328 18 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2016

    Advances and future directions for tuberous sclerosis complex research: Recommendations from the 2015 strategic planning conference

    Sahin, M., Henske, E. P., Manning, B. D., Ess, K. C., Bissler, J. J., Klann, E., Kwiatkowski, D. J., Roberds, S. L., Silva, A. J., Hillaire-Clarke, C. S., Young, L. R., Zervas, M. & Mamounas, L. A., Jul 1 2016, In : Pediatric Neurology. 60, p. 1-12 12 p.

    Research output: Contribution to journalReview article

    Alzheimer's disease: Lost memories found

    Shrestha, P. & Klann, E., Mar 24 2016, In : Nature. 531, 7595, p. 450-451 2 p.

    Research output: Contribution to journalShort survey

    BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

    Bowling, H., Bhattacharya, A., Zhang, G., Lebowitz, J. Z., Alam, D., Smith, P. T., Kirshenbaum, K., Neubert, T. A., Vogel, C., Chao, M. V. & Klann, E., Jan 1 2016, In : Neuropharmacology. 100, p. 76-89 14 p.

    Research output: Contribution to journalArticle

    Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression

    Sethna, F., Zhang, M., Kaphzan, H., Klann, E., Autio, D., Cox, C. L. & Wang, H., May 1 2016, In : Journal of neuroscience research. 94, 5, p. 401-408 8 p.

    Research output: Contribution to journalArticle

    Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology

    Bowling, H., Bhattacharya, A., Klann, E. & Chao, M. V., Mar 2016, In : Neural Regeneration Research. 11, 3, p. 363-367 5 p.

    Research output: Contribution to journalReview article

    Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

    Beckelman, B. C., Day, S., Zhou, X., Donohue, M., Gouras, G. K., Klann, E., Keene, C. D. & Ma, T., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 669-678 10 p.

    Research output: Contribution to journalArticle

    Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

    Santini, E. & Klann, E., Apr 6 2016, In : Neuron. 90, 1, p. 1-3 3 p.

    Research output: Contribution to journalShort survey

    Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

    Yang, W., Zhou, X., Zimmermann, H. R., Cavener, D. R., Klann, E. & Ma, T., May 1 2016, In : Neurobiology of Aging. 41, p. 19-24 6 p.

    Research output: Contribution to journalArticle

    Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

    Bhattacharya, A., Mamcarz, M., Mullins, C., Choudhury, A., Boyle, R. G., Smith, D. G., Walker, D. W. & Klann, E., Jul 1 2016, In : Neuropsychopharmacology. 41, 8, p. 1991-2000 10 p.

    Research output: Contribution to journalArticle

    Translational Control Mechanisms in Synaptic Plasticity and Memory

    Costa-Mattioli, M. & Klann, E., Jan 1 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd, p. 311-328 18 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Translational Control Mechanisms in Synaptic Plasticity and Memory

    Costa-Mattioli, M. & Klann, E., Jan 1 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd, p. 311-328 18 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2015

    Dysregulation and restoration of translational homeostasis in fragile X syndrome

    Richter, J. D., Bassell, G. J. & Klann, E., Oct 19 2015, In : Nature Reviews Neuroscience. 16, 10, p. 595-605 11 p.

    Research output: Contribution to journalReview article

    Dysregulation of mammalian target of rapamycin signaling in mouse models of autism

    Huber, K. M., Klann, E., Costa-Mattioli, M. & Zukin, R. S., Oct 14 2015, In : Journal of Neuroscience. 35, 41, 1 p.

    Research output: Contribution to journalArticle

    eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors

    Huynh, T. N., Shah, M., Koo, S. Y., Faraud, K. S., Santini, E. & Klann, E., Nov 1 2015, In : Neurobiology of Disease. 83, p. 67-74 8 p.

    Research output: Contribution to journalArticle

    Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

    Gross, C., Chang, C. W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., Klann, E., Jongens, T. A., Moberg, K. H., Huber, K. M. & Bassell, G. J., 2015, In : Cell Reports. 11, 5, p. 727-736 10 p.

    Research output: Contribution to journalArticle

    Mitochondrial superoxide contributes to hippocampal synaptic dysfunction and memory deficits in Angelman syndrome model mice

    Santini, E., Turner, K. L., Ramaraj, X. B., Murphy, M. P., Klann, E. & Kaphzan, X., Dec 9 2015, In : Journal of Neuroscience. 35, 49, p. 16213-16220 8 p.

    Research output: Contribution to journalArticle

    RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease

    Wong, H., Levenga, J., Cain, P., Rothermel, B., Klann, E. & Hoeffer, C., Dec 1 2015, In : Acta Neuropathologica. 130, 6, p. 829-843 15 p.

    Research output: Contribution to journalArticle

    Resetting translational homeostasis in fragile X syndrome

    Richter, JD., Bassell, GJ. & Klann, E., 2015, (Accepted/In press) In : Nature Reviews Neuroscience. In Press, In Press.

    Research output: Contribution to journalArticle

    2014

    (Li+)ghting the way for a treatment for cognitive impairments in fragile X syndrome

    Bhattacharya, A. & Klann, E., Feb 1 2014, In : Biological Psychiatry. 75, 3, p. 175-176 2 p.

    Research output: Contribution to journalComment/debate

    Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity

    Bowling, H., Zhang, G., Bhattacharya, A., Pérez-Cuesta, L. M., Deinhardt, K., Hoeffer, C. A., Neubert, T. A., Gan, W. B., Klann, E. & Chao, M. V., Jan 14 2014, In : Science signaling. 7, 308, ra4.

    Research output: Contribution to journalArticle

    Effects of acute sleep deprivation on motor and reversal learning in mice

    Varga, A. W., Kang, M., Ramesh, P. V. & Klann, E., Oct 2014, In : Neurobiology of Learning and Memory. 114, p. 217-222 6 p.

    Research output: Contribution to journalArticle

    How ketamine helps to overcome depression

    Huynh, T. N. & Klann, E., Dec 12 2014, In : eLife. 3, December2014, e05418.

    Research output: Contribution to journalComment/debate

    Identification of fragile X syndrome specific molecular markers in human fibroblasts: A useful model to test the efficacy of therapeutic drugs

    Kumari, D., Bhattacharya, A., Nadel, J., Moulton, K., Zeak, N. M., Glicksman, A., Dobkin, C., Brick, D. J., Schwartz, P. H., Smith, C. B., Klann, E. & Usdin, K., Dec 1 2014, In : Human Mutation. 35, 12, p. 1485-1494 10 p.

    Research output: Contribution to journalArticle

    In-depth quantitative proteomic analysis of de novo protein synthesis induced by brain-derived neurotrophic factor

    Zhang, G., Bowling, H., Hom, N., Kirshenbaum, K., Klann, E., Chao, M. V. & Neubert, T. A., Dec 5 2014, In : Journal of Proteome Research. 13, 12, p. 5707-5714 8 p.

    Research output: Contribution to journalArticle

    Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β

    Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P. & Klann, E., Sep 3 2014, In : Journal of Neuroscience. 34, 36, p. 12230-12238 9 p.

    Research output: Contribution to journalArticle

    Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory

    Santini, E., Huynh, T. N. & Klann, E., 2014, Molecular Basis of Memory. Elsevier B.V., p. 131-167 37 p. (Progress in Molecular Biology and Translational Science; vol. 122).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    PERK: A novel therapeutic target for neurodegenerative diseases?

    Ma, T. & Klann, E., May 29 2014, In : Alzheimer's Research and Therapy. 6, 3, 30.

    Research output: Contribution to journalArticle

    Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction

    Kurinami, H., Shimamura, M., Ma, T., Qian, L., Koizumi, K., Park, L., Klann, E., Manfredi, G., Iadecola, C. & Zhou, P., Apr 2014, In : Stroke. 45, 4, p. 1131-1138 8 p.

    Research output: Contribution to journalArticle

    Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

    Santini, E. & Klann, E., Oct 28 2014, In : Science signaling. 7, 349, 2005832.

    Research output: Contribution to journalReview article

    Regulation of Neuronal Gene Expression and Protein Synthesis

    Alberini, C. M. & Klann, E., Jul 11 2014, From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience: Third Edition. Elsevier Inc., p. 149-174 26 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Requirement of mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence

    Huynh, T. N., Santini, E. & Klann, E., 2014, In : Journal of Neuroscience. 34, 27, p. 9034-9039 6 p.

    Research output: Contribution to journalArticle