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Eric Klann

Professor of Neural Science

    1989 …2020

    Research output per year

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    Research Output

    (Li+)ghting the way for a treatment for cognitive impairments in fragile X syndrome

    Bhattacharya, A. & Klann, E., Feb 1 2014, In : Biological Psychiatry. 75, 3, p. 175-176 2 p.

    Research output: Contribution to journalComment/debate

    Accumulation of polyribosomes in dendritic spine heads, but not bases and necks, during memory consolidation depends on cap-dependent translation initiation

    Ostroff, L. E., Botsford, B., Gindina, S., Cowansage, K. K., Ledoux, J. E., Klann, E. & Hoeffer, C., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1862-1872 11 p.

    Research output: Contribution to journalArticle

    Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

    Huynh, T. N., Santini, E., Mojica, E., Fink, A. E., Hall, B. S., Fetcho, R. N., Grosenick, L., Deisseroth, K., Ledoux, J. E., Liston, C. & Klann, E., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1394-1401 8 p.

    Research output: Contribution to journalArticle

    Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

    Gelinas, J. N., Banko, J. L., Peters, M. M., Klann, E., Weeber, E. J. & Nguyen, P. V., Jun 2008, In : Learning and Memory. 15, 6, p. 403-411 9 p.

    Research output: Contribution to journalArticle

    Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

    Wang, X., Snape, M., Klann, E., Stone, J. G., Singh, A., Petersen, R. B., Castellani, R. J., Casadesus, G., Smith, M. A. & Zhu, X., May 2012, In : Journal of Neurochemistry. 121, 4, p. 672-679 8 p.

    Research output: Contribution to journalArticle

    Advances and future directions for tuberous sclerosis complex research: Recommendations from the 2015 strategic planning conference

    Sahin, M., Henske, E. P., Manning, B. D., Ess, K. C., Bissler, J. J., Klann, E., Kwiatkowski, D. J., Roberds, S. L., Silva, A. J., Hillaire-Clarke, C. S., Young, L. R., Zervas, M. & Mamounas, L. A., Jul 1 2016, In : Pediatric Neurology. 60, p. 1-12 12 p.

    Research output: Contribution to journalReview article

    Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase

    Hu, D., Serrano, F., Oury, T. D. & Klann, E., 2006, In : Journal of Neuroscience. 26, 15, p. 3933-3941 9 p.

    Research output: Contribution to journalArticle

    Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome

    Kaphzan, H., Buffington, S. A., Jung, J. I., Rasband, M. N. & Klann, E., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17637-17648 12 p.

    Research output: Contribution to journalArticle

    Altered hippocampal synaptic plasticity in the Fmr1 gene family knockout mouse models

    Zhang, J., Hou, L., Klann, E. & Nelson, D. L., May 2009, In : Journal of neurophysiology. 101, 5, p. 2572-2580 9 p.

    Research output: Contribution to journalArticle

    Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

    Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E. & Tassone, F., Apr 2012, In : Genes, Brain and Behavior. 11, 3, p. 332-341 10 p.

    Research output: Contribution to journalArticle

    Altered protein synthesis is a trigger for long-term memory formation

    Klann, E. & Sweatt, J. D., Mar 2008, In : Neurobiology of Learning and Memory. 89, 3, p. 247-259 13 p.

    Research output: Contribution to journalArticle

    Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

    Siarey, R. J., Kline-Burgess, A., Cho, M., Balbo, A., Best, T. K., Harashima, C., Klann, E. & Galdzicki, Z., Aug 2006, In : Journal of Neurochemistry. 98, 4, p. 1266-1277 12 p.

    Research output: Contribution to journalArticle

    Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

    Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T. A. & Klann, E., Dec 1 2019, In : Nature communications. 10, 1, 1710.

    Research output: Contribution to journalArticle

    Open Access

    Alzheimer's disease: Lost memories found

    Shrestha, P. & Klann, E., Mar 24 2016, In : Nature. 531, 7595, p. 450-451 2 p.

    Research output: Contribution to journalShort survey

    Amygdala Kindling Alters Protein Kinase C Activity in Dentate Gyrus

    Chen, SJ. J., Desai, M. A., Klann, E., Winder, D. G., Sweatt, J. D. & Conn, P. J., Nov 1992, In : Journal of Neurochemistry. 59, 5, p. 1761-1769 9 p.

    Research output: Contribution to journalArticle

    Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

    Ma, T. & Klann, E., Jan 2012, In : Journal of Neurochemistry. 120, SUPPL. 1, p. 140-148 9 p.

    Research output: Contribution to journalReview article

    Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide

    Ma, T., Hoeffer, C. A., Wong, H., Massaad, C. A., Zhou, P., Iadecola, C., Murphy, M. P., Pautler, R. G. & Klann, E., Apr 13 2011, In : Journal of Neuroscience. 31, 15, p. 5589-5595 7 p.

    Research output: Contribution to journalArticle

    A nitric oxide/cyclic GMP-dependent protein kinase pathway alters transmitter release and inhibition by somatostatin at a site downstream of calcium entry

    Gray, D. B., Polo-Parada, L., Pilar, G. R., Eang, P., Metzger, R. R., Klann, E. & Meriney, S. D., 1999, In : Journal of Neurochemistry. 72, 5, p. 1981-1990 10 p.

    Research output: Contribution to journalArticle

    Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity

    Bowling, H., Zhang, G., Bhattacharya, A., Pérez-Cuesta, L. M., Deinhardt, K., Hoeffer, C. A., Neubert, T. A., Gan, W. B., Klann, E. & Chao, M. V., Jan 14 2014, In : Science signaling. 7, 308, ra4.

    Research output: Contribution to journalArticle

    A nuclear matrix protein stabilized by lead exposure: Current knowledge and future prospects

    Shelton, K. R., Egle, P. M., Bigbee, J. W. & Klann, E., 1993, In : NeuroToxicology. 14, 2-3, p. 61-68 8 p.

    Research output: Contribution to journalReview article

    A procedure for purifying low-abundance protein components from the brain cytoskeleton-nuclear matrix fraction

    Shelton, K. R., Klann, E., Nixon, G. & Egle, P. M., May 1991, In : Journal of Neuroscience Methods. 37, 3, p. 257-266 10 p.

    Research output: Contribution to journalArticle

    A role for superoxide in protein kinase C activation and induction of long-term potentiation

    Klann, E., Roberson, E. D., Knapp, L. T. & Sweatt, J. D., Feb 20 1998, In : Journal of Biological Chemistry. 273, 8, p. 4516-4522 7 p.

    Research output: Contribution to journalArticle

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

    Ostroff, L. E., Santini, E., Sears, R., Deane, Z., Kanadia, R. N., Ledoux, J. E., Lhakhang, T., Tsirigos, A., Heguy, A. & Klann, E., Dec 2019, In : eLife. 8, e51607.

    Research output: Contribution to journalArticle

    Open Access

    Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory

    Cowansage, K. K., Bush, D. E. A., Josselyn, S. A., Klann, E. & LeDoux, J. E., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16645-16650 6 p.

    Research output: Contribution to journalArticle

    Behavioral alterations in mice lacking the translation repressor 4E-BP2

    Banko, J. L., Merhav, M., Stern, E., Sonenberg, N., Rosenblum, K. & Klann, E., Feb 2007, In : Neurobiology of Learning and Memory. 87, 2, p. 248-256 9 p.

    Research output: Contribution to journalArticle

    Biochemical mechanisms for translational regulation in synaptic plasticity

    Klann, E. & Dever, T. E., Dec 2004, In : Nature Reviews Neuroscience. 5, 12, p. 931-942 12 p.

    Research output: Contribution to journalReview article

    Biochemical mechanisms underlying LTD in the hippocampus in vivo

    Klann, E., Norman, E. D., Barrionuevo, G. & Thiels, E., 1996, In : Journal of Physiology Paris. 90, 5-6, p. 415-416 2 p.

    Research output: Contribution to journalArticle

    BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

    Bowling, H., Bhattacharya, A., Zhang, G., Lebowitz, J. Z., Alam, D., Smith, P. T., Kirshenbaum, K., Neubert, T. A., Vogel, C., Chao, M. V. & Klann, E., Jan 1 2016, In : Neuropharmacology. 100, p. 76-89 14 p.

    Research output: Contribution to journalArticle

    Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

    Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R. & Klann, E., Jun 28 2012, In : Cell Reports. 1, 6, p. 676-688 13 p.

    Research output: Contribution to journalArticle

    Ca2+-induced persistent protein kinase C activation in rat hippocampal homogenates

    Sessoms, J. S., Chen, S. J., Chetkovich, D. M., Powell, C. M., Roberson, E. D., Sweatt, J. D. & Klann, E., 1992, In : Second Messengers and Phosphoproteins. 14, 3, p. 109-126 18 p.

    Research output: Contribution to journalArticle

    Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons

    Kemmerling, U., Muñoz, P., Müller, M., Sánchez, G., Aylwin, M. L., Klann, E., Carrasco, M. A. & Hidalgo, C., May 2007, In : Cell Calcium. 41, 5, p. 491-502 12 p.

    Research output: Contribution to journalArticle

    Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression

    Sethna, F., Zhang, M., Kaphzan, H., Klann, E., Autio, D., Cox, C. L. & Wang, H., May 1 2016, In : Journal of neuroscience research. 94, 5, p. 401-408 8 p.

    Research output: Contribution to journalArticle

    CC2D1a loss of function disrupts functional and morphological development in forebrain neurons leading to cognitive and social deficits

    Oaks, A. W., Zamarbide, M., Tambunan, D. E., Santini, E., Costanzo, S. D., Pond, H. L., Johnson, M. W., Lin, J., Gonzalez, D. M., Boehler, J. F., Wu, G. K., Klann, E., Walsh, C. A. & Chiara Manzini, M., 2017, In : Cerebral Cortex. 27, 2, p. 1670-1685 16 p.

    Research output: Contribution to journalArticle

    Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1

    Klann, E., Jul 1998, In : Journal of neurophysiology. 80, 1, p. 452-457 6 p.

    Research output: Contribution to journalArticle

    Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

    Shrestha, P., Ayata, P., Herrero-Vidal, P., Longo, F., Gastone, A., LeDoux, J. E., Heintz, N. & Klann, E., Feb 1 2020, In : Nature Neuroscience. 23, 2, p. 281-292 12 p.

    Research output: Contribution to journalArticle

    Chapter 4 Cap-dependent translation initiation and memory

    Banko, J. L. & Klann, E., 2008, Progress in Brain Research. p. 59-80 22 p. (Progress in Brain Research; vol. 169).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome

    Suvrathan, A., Hoeffer, C. A., Wong, H., Klann, E. & Chattarji, S., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11591-11596 6 p.

    Research output: Contribution to journalArticle

    Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

    Inoue, K., Rispoli, J., Yang, L., MacLeod, D., Beal, M. F., Klann, E. & Abeliovich, A., Oct 2013, In : PLoS genetics. 9, 10, e1003845.

    Research output: Contribution to journalArticle

    CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation

    DeRubeis, S., Pasciuto, E., Li, K. W., Fernández, E., DiMarino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., Sep 18 2013, In : Neuron. 79, 6, p. 1169-1182 14 p.

    Research output: Contribution to journalArticle

    Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology

    Bowling, H., Bhattacharya, A., Klann, E. & Chao, M. V., Mar 2016, In : Neural Regeneration Research. 11, 3, p. 363-367 5 p.

    Research output: Contribution to journalReview article

    Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression

    Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R. & Klann, E., Aug 17 2006, In : Neuron. 51, 4, p. 441-454 14 p.

    Research output: Contribution to journalArticle

    Dysregulation and restoration of translational homeostasis in fragile X syndrome

    Richter, J. D., Bassell, G. J. & Klann, E., Oct 19 2015, In : Nature Reviews Neuroscience. 16, 10, p. 595-605 11 p.

    Research output: Contribution to journalReview article

    Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

    Beckelman, B. C., Day, S., Zhou, X., Donohue, M., Gouras, G. K., Klann, E., Keene, C. D. & Ma, T., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 669-678 10 p.

    Research output: Contribution to journalArticle

    Dysregulation of mammalian target of rapamycin signaling in mouse models of autism

    Huber, K. M., Klann, E., Costa-Mattioli, M. & Zukin, R. S., Oct 14 2015, In : Journal of Neuroscience. 35, 41, 1 p.

    Research output: Contribution to journalArticle

    Dysregulation of mTOR signaling in fragile X syndrome

    Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E. & Suzanne Zukin, R., Jan 13 2010, In : Journal of Neuroscience. 30, 2, p. 694-702 9 p.

    Research output: Contribution to journalArticle

    Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

    Ma, T., Hoeffer, C. A., Capetillo-Zarate, E., Yu, F., Wong, H., Lin, M. T., Tampellini, D., Klann, E., Blitzer, R. D. & Gouras, G. K., 2010, In : PloS one. 5, 9, p. 1-10 10 p., e12845.

    Research output: Contribution to journalArticle

    Early changes in the Apparent Diffusion Coefficient (ADC) in a mouse model of sandhoff's disease occur prior to disease symptoms and behavioral deficits

    Lingyun, H., Yingying, S., Villasana, L. E., Paylor, R., Klann, E. & Pautler, R. G., Nov 2009, In : Magnetic resonance in medicine. 62, 5, p. 1175-1184 10 p.

    Research output: Contribution to journalArticle