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Eric Klann

Professor of Neural Science

    1989 …2020

    Research output per year

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    Research Output

    2014

    Shaping Dendritic Spines in Autism Spectrum Disorder: mTORC1-Dependent Macroautophagy

    Bowling, H. & Klann, E., Sep 3 2014, In : Neuron. 83, 5, p. 994-996 3 p.

    Research output: Contribution to journalShort survey

    The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

    Trinh, M. A., Ma, T., Kaphzan, H., Bhattacharya, A., Antion, M. D., Cavener, D. R., Hoeffer, C. A. & Klann, E., May 2014, In : Learning and Memory. 21, 5, p. 298-304 7 p.

    Research output: Contribution to journalArticle

    2013

    Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory

    Cowansage, K. K., Bush, D. E. A., Josselyn, S. A., Klann, E. & LeDoux, J. E., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16645-16650 6 p.

    Research output: Contribution to journalArticle

    Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

    Inoue, K., Rispoli, J., Yang, L., MacLeod, D., Beal, M. F., Klann, E. & Abeliovich, A., Oct 2013, In : PLoS genetics. 9, 10, e1003845.

    Research output: Contribution to journalArticle

    CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation

    DeRubeis, S., Pasciuto, E., Li, K. W., Fernández, E., DiMarino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., Sep 18 2013, In : Neuron. 79, 6, p. 1169-1182 14 p.

    Research output: Contribution to journalArticle

    Exaggerated translation causes synaptic and behavioural aberrations associated with autism

    Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H. & Klann, E., Jan 17 2013, In : Nature. 493, 7432, p. 411-415 5 p.

    Research output: Contribution to journalArticle

    Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

    Udagawa, T., Farny, N. G., Jakovcevski, M., Kaphzan, H., Alarcon, J. M., Anilkumar, S., Ivshina, M., Hurt, J. A., Nagaoka, K., Nalavadi, V. C., Lorenz, L. J., Bassell, G. J., Akbarian, S., Chattarji, S., Klann, E. & Richter, J. D., Nov 2013, In : Nature Medicine. 19, 11, p. 1473-1477 5 p.

    Research output: Contribution to journalArticle

    Genetic reduction of the α1 Subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in angelman syndrome

    Kaphzan, H., Buffington, S. A., Ramaraj, A. B., Lingrel, J. B., Rasband, M. N., Santini, E. & Klann, E., 2013, In : Cell Reports. 4, 3, p. 405-412 8 p.

    Research output: Contribution to journalArticle

    Molecular and cellular cognition: Neurobiology of Learning and Memory Special Issue 2013

    Abel, T. & Klann, E., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 1-2 2 p.

    Research output: Contribution to journalEditorial

    Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation

    Hoeffer, C. A., Santini, E., Ma, T., Arnold, E. C., Whelan, A. M., Arnold, E. C., Pierre, P., Pelletier, J. & Klann, E., Jan 1 2013, In : Journal of neurophysiology. 109, 1, p. 68-76 9 p.

    Research output: Contribution to journalArticle

    Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment

    Hoeffer, C. A., Wong, H., Cain, P., Levenga, J., Cowansage, K. K., Choi, Y., Davy, C., Majmundar, N., Randy McMillan, D., Rothermel, B. A. & Klann, E., 2013, In : Journal of Neuroscience. 33, 43, p. 16930-16944 15 p.

    Research output: Contribution to journalArticle

    Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

    Ma, T., Trinh, M. A., Wexler, A. J., Bourbon, C., Gatti, E., Pierre, P., Cavener, D. R. & Klann, E., Sep 2013, In : Nature Neuroscience. 16, 9, p. 1299-1305 7 p.

    Research output: Contribution to journalArticle

    The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

    Pick, J. E., Malumbres, M. & Klann, E., Jan 2013, In : Learning and Memory. 20, 1, p. 11-20 10 p.

    Research output: Contribution to journalArticle

    The translation of translational control by FMRP: Therapeutic targets for FXS

    Darnell, J. C. & Klann, E., Nov 2013, In : Nature Neuroscience. 16, 11, p. 1530-1536 7 p.

    Research output: Contribution to journalReview article

    Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

    Trinh, M. A. & Klann, E., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 93-99 7 p.

    Research output: Contribution to journalArticle

    Translational regulation of hippocampal plasticity

    Hoeffer, C. A., Santini, E. & Klann, E., 2013, Multidisciplinary tools for investigating synaptic plasticity. Nguyen, PV. (ed.). Humana Press, p. 93-124

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Translational regulation of synaptic plasticity

    Hoeffer, C. A., Santini, E. & Klann, E., 2013, Multidisciplinary Tools for Investigating Synaptic Plasticity. Nguyen, P. V. (ed.). p. 93-124 32 p. (Neuromethods; vol. 81).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2012

    Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

    Wang, X., Snape, M., Klann, E., Stone, J. G., Singh, A., Petersen, R. B., Castellani, R. J., Casadesus, G., Smith, M. A. & Zhu, X., May 2012, In : Journal of Neurochemistry. 121, 4, p. 672-679 8 p.

    Research output: Contribution to journalArticle

    Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

    Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E. & Tassone, F., Apr 2012, In : Genes, Brain and Behavior. 11, 3, p. 332-341 10 p.

    Research output: Contribution to journalArticle

    Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

    Ma, T. & Klann, E., Jan 2012, In : Journal of Neurochemistry. 120, SUPPL. 1, p. 140-148 9 p.

    Research output: Contribution to journalReview article

    Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

    Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R. & Klann, E., Jun 28 2012, In : Cell Reports. 1, 6, p. 676-688 13 p.

    Research output: Contribution to journalArticle

    Fragile X Syndrome Therapeutics S(C)TEP through the Developmental Window

    Bhattacharya, A. & Klann, E., Apr 12 2012, In : Neuron. 74, 1, p. 1-3 3 p.

    Research output: Contribution to journalShort survey

    Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

    Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P. & Klann, E., Oct 18 2012, In : Neuron. 76, 2, p. 325-337 13 p.

    Research output: Contribution to journalArticle

    Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice

    Ma, T., Du, X., Pick, J. E., Sui, G., Brownlee, M. & Klann, E., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13701-13708 8 p.

    Research output: Contribution to journalArticle

    Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

    Chévere-Torres, I., Maki, J. M., Santini, E. & Klann, E., Jan 2012, In : Neurobiology of Disease. 45, 1, p. 156-164 9 p.

    Research output: Contribution to journalArticle

    Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

    Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M. & Abeliovich, A., 2012, In : Molecular Neurodegeneration. 7, 1, 48.

    Research output: Contribution to journalArticle

    Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the δRG mouse model of tuberous sclerosis complex

    Chévere-Torres, I., Kaphzan, H., Bhattacharya, A., Kang, A., Maki, J. M., Gambello, M. J., Arbiser, J. L., Santini, E. & Klann, E., Mar 2012, In : Neurobiology of Disease. 45, 3, p. 1101-1110 10 p.

    Research output: Contribution to journalArticle

    Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic plasticity

    Bagni, C. & Klann, E., 2012, The autisms: Molecules to model systems. Powell, CM. & Monteggia, LM. (eds.). Oxford University Press, p. 126-146

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in angelman syndrome model mice by ErbB inhibitors

    Kaphzan, H., Hernandez, P., Jung, J. I., Cowansage, K. K., Deinhardt, K., Chao, M. V., Abel, T. & Klann, E., Aug 1 2012, In : Biological Psychiatry. 72, 3, p. 182-190 9 p.

    Research output: Contribution to journalArticle

    The molecular basis of cognitive deficits in pervasive developmental disorders

    Bhattacharya, A. & Klann, E., Sep 2012, In : Learning and Memory. 19, 9, p. 434-443 10 p.

    Research output: Contribution to journalReview article

    2011

    Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome

    Kaphzan, H., Buffington, S. A., Jung, J. I., Rasband, M. N. & Klann, E., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17637-17648 12 p.

    Research output: Contribution to journalArticle

    Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide

    Ma, T., Hoeffer, C. A., Wong, H., Massaad, C. A., Zhou, P., Iadecola, C., Murphy, M. P., Pautler, R. G. & Klann, E., Apr 13 2011, In : Journal of Neuroscience. 31, 15, p. 5589-5595 7 p.

    Research output: Contribution to journalArticle

    Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus

    Connor, S. A., Hoeffer, C. A., Klann, E. & Nguyen, P. V., Apr 2011, In : Learning and Memory. 18, 4, p. 207-220 14 p.

    Research output: Contribution to journalArticle

    Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32

    Valjent, E., Bertran-Gonzalez, J., Bowling, H., Lopez, S., Santini, E., Matamales, M., Bonito-Oliva, A., Hervé, D., Hoeffer, C., Klann, E., Girault, J. A. & Fisone, G., Nov 2011, In : Neuropsychopharmacology. 36, 12, p. 2561-2570 10 p.

    Research output: Contribution to journalArticle

    Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

    Hoeffer, C. A., Cowansage, K. K., Arnold, E. C., Banko, J. L., Moerke, N. J., Rodriguez, R., Schmidt, E. K., Klosi, E., Chorev, M., Lloyd, R. E., Pierre, P., Wagner, G., LeDoux, J. E. & Klann, E., Feb 22 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 8, p. 3383-3388 6 p.

    Research output: Contribution to journalArticle

    Local RNA translation at the synapse and in disease

    Liu-Yesucevitz, L., Bassell, G. J., Gitler, A. D., Hart, A. C., Klann, E., Richter, J. D., Warren, S. T. & Wolozin, B., Nov 9 2011, In : Journal of Neuroscience. 31, 45, p. 16086-16093 8 p.

    Research output: Contribution to journalArticle

    Reactive oxygen species in the regulation of synaptic plasticity and memory

    Massaad, C. A. & Klann, E., May 15 2011, In : Antioxidants and Redox Signaling. 14, 10, p. 2013-2054 42 p.

    Research output: Contribution to journalReview article

    2010

    Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome

    Suvrathan, A., Hoeffer, C. A., Wong, H., Klann, E. & Chattarji, S., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11591-11596 6 p.

    Research output: Contribution to journalArticle

    Dysregulation of mTOR signaling in fragile X syndrome

    Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E. & Suzanne Zukin, R., Jan 13 2010, In : Journal of Neuroscience. 30, 2, p. 694-702 9 p.

    Research output: Contribution to journalArticle

    Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease

    Ma, T., Hoeffer, C. A., Capetillo-Zarate, E., Yu, F., Wong, H., Lin, M. T., Tampellini, D., Klann, E., Blitzer, R. D. & Gouras, G. K., 2010, In : PloS one. 5, 9, p. 1-10 10 p., e12845.

    Research output: Contribution to journalArticle

    Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease

    Massaad, C. A., Amin, S. K., Hu, L., Mei, Y., Klann, E. & Pautler, R. G., 2010, In : PloS one. 5, 5, e10561.

    Research output: Contribution to journalArticle

    mTOR signaling: At the crossroads of plasticity, memory and disease

    Hoeffer, C. A. & Klann, E., Feb 2010, In : Trends in Neurosciences. 33, 2, p. 67-75 9 p.

    Research output: Contribution to journalReview article

    2009

    Altered hippocampal synaptic plasticity in the Fmr1 gene family knockout mouse models

    Zhang, J., Hou, L., Klann, E. & Nelson, D. L., May 2009, In : Journal of neurophysiology. 101, 5, p. 2572-2580 9 p.

    Research output: Contribution to journalArticle

    Early changes in the Apparent Diffusion Coefficient (ADC) in a mouse model of sandhoff's disease occur prior to disease symptoms and behavioral deficits

    Lingyun, H., Yingying, S., Villasana, L. E., Paylor, R., Klann, E. & Pautler, R. G., Nov 2009, In : Magnetic resonance in medicine. 62, 5, p. 1175-1184 10 p.

    Research output: Contribution to journalArticle

    Extinction-Reconsolidation boundaries: Key to persistent attenuation of fear memories

    Monfils, M. H., Cowansage, K. K., Klann, E. & Ledoux, J. E., May 15 2009, In : Science. 324, 5929, p. 951-955 5 p.

    Research output: Contribution to journalArticle

    Making synaptic plasticity and memory last: Mechanisms of translational regulation

    Richter, J. D. & Klann, E., Jan 1 2009, In : Genes and Development. 23, 1, p. 1-11 11 p.

    Research output: Contribution to journalReview article

    Mitochondrial superoxide: A key player in Alzheimer's disease

    Massaad, C. A., Pautler, R. G. & Klann, E., Sep 2009, In : Aging. 1, 9, p. 758-761 4 p.

    Research output: Contribution to journalArticle

    NADPH oxidase mediates -amyloid peptide-induced activation of ERK in hippocampal organotypic cultures

    Serrano, F., Chang, A., Hernandez, C., Pautler, R. G., Sweatt, J. D. & Klann, E., 2009, In : Molecular Brain. 2, 1, 31.

    Research output: Contribution to journalArticle