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Eric Klann

Professor of Neural Science

    1989 …2020

    Research output per year

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    Research Output

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    2020

    Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

    Shrestha, P., Ayata, P., Herrero-Vidal, P., Longo, F., Gastone, A., LeDoux, J. E., Heintz, N. & Klann, E., Feb 1 2020, In : Nature Neuroscience. 23, 2, p. 281-292 12 p.

    Research output: Contribution to journalArticle

    Interactions between sleep disruption, motor learning, and p70 S6 kinase 1 signaling

    Kam, K., Kang, M., Eren, C. Y., Pettibone, W. D., Bowling, H., Taveras, S., Ly, A., Chen, R. K., Berryman, N. V., Klann, E. & Varga, A. W., Mar 12 2020, In : Sleep. 43, 3

    Research output: Contribution to journalArticle

    N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells

    Venkatasubramani, J. P., Subramanyam, P., Pal, R., Reddy, B. K., Srinivasan, D. J., Chattarji, S., Iossifov, I., Klann, E. & Bhattacharya, A., May 2020, In : Neurobiology of Learning and Memory. 171, 107203.

    Research output: Contribution to journalArticle

    Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB

    Young-Baird, S. K., Lourenço, M. B., Elder, M. K., Klann, E., Liebau, S. & Dever, T. E., Feb 20 2020, In : Molecular Cell. 77, 4, p. 875-886.e7

    Research output: Contribution to journalArticle

    2019

    Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

    Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T. A. & Klann, E., Dec 1 2019, In : Nature communications. 10, 1, 1710.

    Research output: Contribution to journalArticle

    Open Access

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

    Ostroff, L. E., Santini, E., Sears, R., Deane, Z., Kanadia, R. N., Ledoux, J. E., Lhakhang, T., Tsirigos, A., Heguy, A. & Klann, E., Dec 2019, In : eLife. 8, e51607.

    Research output: Contribution to journalArticle

    Open Access

    Inositol polyphosphate multikinase mediates extinction of fear memory

    Park, J., Longo, F., Park, S. J., Lee, S., Bae, M., Tyagi, R., Han, J. H., Kim, S., Santini, E., Klann, E. & Snyder, S. H., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2707-2712 6 p.

    Research output: Contribution to journalArticle

    Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

    Gross, C., Banerjee, A., Tiwari, D., Longo, F., White, A. R., Allen, A. G., Schroeder-Carter, L. M., Krzeski, J. C., Elsayed, N. A., Puckett, R., Klann, E., Rivero, R. A., Gourley, S. L. & Bassell, G. J., Jan 1 2019, In : Neuropsychopharmacology. 44, 2, p. 324-333 10 p.

    Research output: Contribution to journalArticle

    UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function

    Notaras, M., Allen, M., Longo, F., Volk, N., Toth, M., Li Jeon, N., Klann, E. & Colak, D., 2019, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

    2018

    Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

    Huynh, T. N., Santini, E., Mojica, E., Fink, A. E., Hall, B. S., Fetcho, R. N., Grosenick, L., Deisseroth, K., Ledoux, J. E., Liston, C. & Klann, E., Jun 1 2018, In : Molecular Psychiatry. 23, 6, p. 1394-1401 8 p.

    Research output: Contribution to journalArticle

    2017

    Accumulation of polyribosomes in dendritic spine heads, but not bases and necks, during memory consolidation depends on cap-dependent translation initiation

    Ostroff, L. E., Botsford, B., Gindina, S., Cowansage, K. K., Ledoux, J. E., Klann, E. & Hoeffer, C., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1862-1872 11 p.

    Research output: Contribution to journalArticle

    CC2D1a loss of function disrupts functional and morphological development in forebrain neurons leading to cognitive and social deficits

    Oaks, A. W., Zamarbide, M., Tambunan, D. E., Santini, E., Costanzo, S. D., Pond, H. L., Johnson, M. W., Lin, J., Gonzalez, D. M., Boehler, J. F., Wu, G. K., Klann, E., Walsh, C. A. & Chiara Manzini, M., 2017, In : Cerebral Cortex. 27, 2, p. 1670-1685 16 p.

    Research output: Contribution to journalArticle

    Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

    Santini, E., Huynh, T. N., Longo, F., Koo, S. Y., Mojica, E., D'Andrea, L., Bagni, C. & Klann, E., Nov 7 2017, In : Science signaling. 10, 504, eaan0665.

    Research output: Contribution to journalArticle

    2016

    BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

    Bowling, H., Bhattacharya, A., Zhang, G., Lebowitz, J. Z., Alam, D., Smith, P. T., Kirshenbaum, K., Neubert, T. A., Vogel, C., Chao, M. V. & Klann, E., Jan 1 2016, In : Neuropharmacology. 100, p. 76-89 14 p.

    Research output: Contribution to journalArticle

    Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression

    Sethna, F., Zhang, M., Kaphzan, H., Klann, E., Autio, D., Cox, C. L. & Wang, H., May 1 2016, In : Journal of neuroscience research. 94, 5, p. 401-408 8 p.

    Research output: Contribution to journalArticle

    Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease

    Beckelman, B. C., Day, S., Zhou, X., Donohue, M., Gouras, G. K., Klann, E., Keene, C. D. & Ma, T., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 669-678 10 p.

    Research output: Contribution to journalArticle

    Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

    Yang, W., Zhou, X., Zimmermann, H. R., Cavener, D. R., Klann, E. & Ma, T., May 1 2016, In : Neurobiology of Aging. 41, p. 19-24 6 p.

    Research output: Contribution to journalArticle

    Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

    Bhattacharya, A., Mamcarz, M., Mullins, C., Choudhury, A., Boyle, R. G., Smith, D. G., Walker, D. W. & Klann, E., Jul 1 2016, In : Neuropsychopharmacology. 41, 8, p. 1991-2000 10 p.

    Research output: Contribution to journalArticle

    2015

    Dysregulation of mammalian target of rapamycin signaling in mouse models of autism

    Huber, K. M., Klann, E., Costa-Mattioli, M. & Zukin, R. S., Oct 14 2015, In : Journal of Neuroscience. 35, 41, 1 p.

    Research output: Contribution to journalArticle

    eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors

    Huynh, T. N., Shah, M., Koo, S. Y., Faraud, K. S., Santini, E. & Klann, E., Nov 1 2015, In : Neurobiology of Disease. 83, p. 67-74 8 p.

    Research output: Contribution to journalArticle

    Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

    Gross, C., Chang, C. W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., Klann, E., Jongens, T. A., Moberg, K. H., Huber, K. M. & Bassell, G. J., 2015, In : Cell Reports. 11, 5, p. 727-736 10 p.

    Research output: Contribution to journalArticle

    Mitochondrial superoxide contributes to hippocampal synaptic dysfunction and memory deficits in Angelman syndrome model mice

    Santini, E., Turner, K. L., Ramaraj, X. B., Murphy, M. P., Klann, E. & Kaphzan, X., Dec 9 2015, In : Journal of Neuroscience. 35, 49, p. 16213-16220 8 p.

    Research output: Contribution to journalArticle

    RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer’s disease

    Wong, H., Levenga, J., Cain, P., Rothermel, B., Klann, E. & Hoeffer, C., Dec 1 2015, In : Acta Neuropathologica. 130, 6, p. 829-843 15 p.

    Research output: Contribution to journalArticle

    Resetting translational homeostasis in fragile X syndrome

    Richter, JD., Bassell, GJ. & Klann, E., 2015, (Accepted/In press) In : Nature Reviews Neuroscience. In Press, In Press.

    Research output: Contribution to journalArticle

    2014

    Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity

    Bowling, H., Zhang, G., Bhattacharya, A., Pérez-Cuesta, L. M., Deinhardt, K., Hoeffer, C. A., Neubert, T. A., Gan, W. B., Klann, E. & Chao, M. V., Jan 14 2014, In : Science signaling. 7, 308, ra4.

    Research output: Contribution to journalArticle

    Effects of acute sleep deprivation on motor and reversal learning in mice

    Varga, A. W., Kang, M., Ramesh, P. V. & Klann, E., Oct 2014, In : Neurobiology of Learning and Memory. 114, p. 217-222 6 p.

    Research output: Contribution to journalArticle

    Identification of fragile X syndrome specific molecular markers in human fibroblasts: A useful model to test the efficacy of therapeutic drugs

    Kumari, D., Bhattacharya, A., Nadel, J., Moulton, K., Zeak, N. M., Glicksman, A., Dobkin, C., Brick, D. J., Schwartz, P. H., Smith, C. B., Klann, E. & Usdin, K., Dec 1 2014, In : Human Mutation. 35, 12, p. 1485-1494 10 p.

    Research output: Contribution to journalArticle

    In-depth quantitative proteomic analysis of de novo protein synthesis induced by brain-derived neurotrophic factor

    Zhang, G., Bowling, H., Hom, N., Kirshenbaum, K., Klann, E., Chao, M. V. & Neubert, T. A., Dec 5 2014, In : Journal of Proteome Research. 13, 12, p. 5707-5714 8 p.

    Research output: Contribution to journalArticle

    Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β

    Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P. & Klann, E., Sep 3 2014, In : Journal of Neuroscience. 34, 36, p. 12230-12238 9 p.

    Research output: Contribution to journalArticle

    PERK: A novel therapeutic target for neurodegenerative diseases?

    Ma, T. & Klann, E., May 29 2014, In : Alzheimer's Research and Therapy. 6, 3, 30.

    Research output: Contribution to journalArticle

    Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction

    Kurinami, H., Shimamura, M., Ma, T., Qian, L., Koizumi, K., Park, L., Klann, E., Manfredi, G., Iadecola, C. & Zhou, P., Apr 2014, In : Stroke. 45, 4, p. 1131-1138 8 p.

    Research output: Contribution to journalArticle

    Requirement of mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence

    Huynh, T. N., Santini, E. & Klann, E., 2014, In : Journal of Neuroscience. 34, 27, p. 9034-9039 6 p.

    Research output: Contribution to journalArticle

    The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

    Trinh, M. A., Ma, T., Kaphzan, H., Bhattacharya, A., Antion, M. D., Cavener, D. R., Hoeffer, C. A. & Klann, E., May 2014, In : Learning and Memory. 21, 5, p. 298-304 7 p.

    Research output: Contribution to journalArticle

    2013

    Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory

    Cowansage, K. K., Bush, D. E. A., Josselyn, S. A., Klann, E. & LeDoux, J. E., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. 16645-16650 6 p.

    Research output: Contribution to journalArticle

    Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway

    Inoue, K., Rispoli, J., Yang, L., MacLeod, D., Beal, M. F., Klann, E. & Abeliovich, A., Oct 2013, In : PLoS genetics. 9, 10, e1003845.

    Research output: Contribution to journalArticle

    CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic Spine formation

    DeRubeis, S., Pasciuto, E., Li, K. W., Fernández, E., DiMarino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., Sep 18 2013, In : Neuron. 79, 6, p. 1169-1182 14 p.

    Research output: Contribution to journalArticle

    Exaggerated translation causes synaptic and behavioural aberrations associated with autism

    Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H. & Klann, E., Jan 17 2013, In : Nature. 493, 7432, p. 411-415 5 p.

    Research output: Contribution to journalArticle

    Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

    Udagawa, T., Farny, N. G., Jakovcevski, M., Kaphzan, H., Alarcon, J. M., Anilkumar, S., Ivshina, M., Hurt, J. A., Nagaoka, K., Nalavadi, V. C., Lorenz, L. J., Bassell, G. J., Akbarian, S., Chattarji, S., Klann, E. & Richter, J. D., Nov 2013, In : Nature Medicine. 19, 11, p. 1473-1477 5 p.

    Research output: Contribution to journalArticle

    Genetic reduction of the α1 Subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in angelman syndrome

    Kaphzan, H., Buffington, S. A., Ramaraj, A. B., Lingrel, J. B., Rasband, M. N., Santini, E. & Klann, E., 2013, In : Cell Reports. 4, 3, p. 405-412 8 p.

    Research output: Contribution to journalArticle

    Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation

    Hoeffer, C. A., Santini, E., Ma, T., Arnold, E. C., Whelan, A. M., Arnold, E. C., Pierre, P., Pelletier, J. & Klann, E., Jan 1 2013, In : Journal of neurophysiology. 109, 1, p. 68-76 9 p.

    Research output: Contribution to journalArticle

    Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment

    Hoeffer, C. A., Wong, H., Cain, P., Levenga, J., Cowansage, K. K., Choi, Y., Davy, C., Majmundar, N., Randy McMillan, D., Rothermel, B. A. & Klann, E., 2013, In : Journal of Neuroscience. 33, 43, p. 16930-16944 15 p.

    Research output: Contribution to journalArticle

    Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits

    Ma, T., Trinh, M. A., Wexler, A. J., Bourbon, C., Gatti, E., Pierre, P., Cavener, D. R. & Klann, E., Sep 2013, In : Nature Neuroscience. 16, 9, p. 1299-1305 7 p.

    Research output: Contribution to journalArticle

    The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

    Pick, J. E., Malumbres, M. & Klann, E., Jan 2013, In : Learning and Memory. 20, 1, p. 11-20 10 p.

    Research output: Contribution to journalArticle

    Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

    Trinh, M. A. & Klann, E., Oct 2013, In : Neurobiology of Learning and Memory. 105, p. 93-99 7 p.

    Research output: Contribution to journalArticle

    2012

    Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

    Wang, X., Snape, M., Klann, E., Stone, J. G., Singh, A., Petersen, R. B., Castellani, R. J., Casadesus, G., Smith, M. A. & Zhu, X., May 2012, In : Journal of Neurochemistry. 121, 4, p. 672-679 8 p.

    Research output: Contribution to journalArticle

    Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

    Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E. & Tassone, F., Apr 2012, In : Genes, Brain and Behavior. 11, 3, p. 332-341 10 p.

    Research output: Contribution to journalArticle

    Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

    Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R. & Klann, E., Jun 28 2012, In : Cell Reports. 1, 6, p. 676-688 13 p.

    Research output: Contribution to journalArticle

    Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

    Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P. & Klann, E., Oct 18 2012, In : Neuron. 76, 2, p. 325-337 13 p.

    Research output: Contribution to journalArticle

    Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice

    Ma, T., Du, X., Pick, J. E., Sui, G., Brownlee, M. & Klann, E., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13701-13708 8 p.

    Research output: Contribution to journalArticle