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Kent Kirshenbaum

Professor of Chemistry

    1993 …2020

    Research output per year

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    Research Output

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    2020

    Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets

    Kim, J. H., Kim, S. C., Kline, M. A., Grzincic, E. M., Tresca, B. W., Cardiel, J., Karbaschi, M., Dehigaspitiya, D. C., Chen, Y., Udumula, V., Jian, T., Murray, D. J., Yun, L., Connolly, M. D., Liu, J., Ren, G., Chen, C. L., Kirshenbaum, K., Abate, A. R. & Zuckermann, R. N., Jan 28 2020, In : ACS nano. 14, 1, p. 185-195 11 p.

    Research output: Contribution to journalArticle

    2019

    Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

    Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T. A. & Klann, E., Dec 1 2019, In : Nature communications. 10, 1, 1710.

    Research output: Contribution to journalArticle

    Open Access

    Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP Sc and Targeting PrP Sc for Lysosomal Degradation

    Pankiewicz, J. E., Sanchez, S., Kirshenbaum, K., Kascsak, R. B., Kascsak, R. J. & Sadowski, M. J., Mar 1 2019, In : Molecular Neurobiology. 56, 3, p. 2073-2091 19 p.

    Research output: Contribution to journalArticle

    2018

    Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

    Schneider, J. A., Craven, T. W., Kasper, A. C., Yun, C., Haugbro, M., Briggs, E. M., Svetlov, V., Nudler, E., Knaut, H., Bonneau, R., Garabedian, M. J., Kirshenbaum, K. & Logan, S. K., Dec 1 2018, In : Nature communications. 9, 1, 4396.

    Research output: Contribution to journalArticle

    Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition

    Battigelli, A., Kim, J. H., Dehigaspitiya, D. C., Proulx, C., Robertson, E. J., Murray, D. J., Rad, B., Kirshenbaum, K. & Zuckermann, R. N., Mar 27 2018, In : ACS nano. 12, 3, p. 2455-2465 11 p.

    Research output: Contribution to journalArticle

    Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

    Andreev, K., Martynowycz, M. W., Huang, M. L., Kuzmenko, I., Bu, W., Kirshenbaum, K. & Gidalevitz, D., Jun 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 6, p. 1414-1423 10 p.

    Research output: Contribution to journalArticle

    Nanoparticle delivery of RNA-based therapeutics to alter the vocal fold tissue response to injury

    Hiwatashi, N., Kraja, I., Benedict, P. A., Dion, G. R., Bing, R., Rousseau, B., Amin, M. R., Nalband, D. M., Kirshenbaum, K. & Branski, R. C., May 2018, In : Laryngoscope. 128, 5, p. E178-E183

    Research output: Contribution to journalArticle

    2017

    Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts

    Kraja, I., Bing, R., Hiwatashi, N., Rousseau, B., Nalband, D., Kirshenbaum, K. & Branski, R. C., Jul 2017, In : Laryngoscope. 127, 7, p. E231-E237

    Research output: Contribution to journalArticle

    2016

    A Miniature Protein Stabilized by a Cation-π Interaction Network

    Craven, T. W., Cho, M. K., Traaseth, N. J., Bonneau, R. & Kirshenbaum, K., Feb 17 2016, In : Journal of the American Chemical Society. 138, 5, p. 1543-1550 8 p.

    Research output: Contribution to journalArticle

    BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

    Bowling, H., Bhattacharya, A., Zhang, G., Lebowitz, J. Z., Alam, D., Smith, P. T., Kirshenbaum, K., Neubert, T. A., Vogel, C., Chao, M. V. & Klann, E., Jan 1 2016, In : Neuropharmacology. 100, p. 76-89 14 p.

    Research output: Contribution to journalArticle

    Cyclization Improves Membrane Permeation by Antimicrobial Peptoids

    Andreev, K., Martynowycz, M. W., Ivankin, A., Huang, M. L., Kuzmenko, I., Meron, M., Lin, B., Kirshenbaum, K. & Gidalevitz, D., Dec 6 2016, In : Langmuir. 32, 48, p. 12905-12913 9 p.

    Research output: Contribution to journalArticle

    Multivalent peptoid conjugates which overcome enzalutamide resistance in prostate cancer cells

    Wang, Y., Dehigaspitiya, D. C., Levine, P. M., Profit, A. A., Haugbro, M., Imberg-Kazdan, K., Logan, S. K., Kirshenbaum, K. & Garabedian, M. J., Sep 1 2016, In : Cancer Research. 76, 17, p. 5124-5132 9 p.

    Research output: Contribution to journalArticle

    PPII Helical Peptidomimetics Templated by Cation–π Interactions

    Craven, T. W., Bonneau, R. & Kirshenbaum, K., Oct 4 2016, In : ChemBioChem. p. 1824-1828 5 p.

    Research output: Contribution to journalArticle

    2015

    Osmoprotective polymer additives attenuate the membrane pore-forming activity of antimicrobial peptoids

    Smith, P. T., Huang, M. L. & Kirshenbaum, K., Apr 1 2015, In : Biopolymers. 103, 4, p. 227-236 10 p.

    Research output: Contribution to journalArticle

    2014

    A rotamer library to enable modeling and design of peptoid foldamers

    Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Kirshenbaum, K. & Bonneau, R., Jun 18 2014, In : Journal of the American Chemical Society. 136, 24, p. 8772-8782 11 p.

    Research output: Contribution to journalArticle

    Conformational preferences of Peptide - Peptoid hybrid oligomers

    Butterfoss, G. L., Drew, K., Renfrew, P. D., Kirshenbaum, K. & Bonneau, R., Sep 1 2014, In : Biopolymers - Peptide Science Section. 102, 5, p. 369-378 10 p.

    Research output: Contribution to journalArticle

    In-depth quantitative proteomic analysis of de novo protein synthesis induced by brain-derived neurotrophic factor

    Zhang, G., Bowling, H., Hom, N., Kirshenbaum, K., Klann, E., Chao, M. V. & Neubert, T. A., Dec 5 2014, In : Journal of Proteome Research. 13, 12, p. 5707-5714 8 p.

    Research output: Contribution to journalArticle

    Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

    Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Jun 3 2014, In : Chemical Communications. 50, 52, p. 6909-6912 4 p.

    Research output: Contribution to journalArticle

    Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: Physical characterization and biological activity

    Konca, Y. U., Kirshenbaum, K. & Zuckermann, R. N., May 10 2014, In : International Journal of Nanomedicine. 9, 1, p. 2271-2285 15 p.

    Research output: Contribution to journalArticle

    Rapid identification of metal-binding peptoid oligomers by on-resin x-ray fluorescence screening

    Nalband, D. M., Warner, B. P., Zahler, N. H. & Kirshenbaum, K., Sep 1 2014, In : Biopolymers - Peptide Science Section. 102, 5, p. 407-415 9 p.

    Research output: Contribution to journalArticle

    Semisynthesis of peptoid-protein hybrids by chemical ligation at serine

    Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Mar 17 2014, In : Organic Letters. 16, 2, p. 512-515 4 p.

    Research output: Contribution to journalArticle

    Targeting the androgen receptor with steroid conjugates

    Levine, P. M., Garabedian, M. J. & Kirshenbaum, K., Oct 23 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8224-8237 14 p.

    Research output: Contribution to journalArticle

    2013

    Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design

    Drew, K., Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Chou, F. C., Lyskov, S., Bullock, B. N., Watkins, A., Labonte, J. W., Pacella, M., Kilambi, K. P., Leaver-Fay, A., Kuhlman, B., Gray, J. J., Bradley, P., Kirshenbaum, K., Arora, P. S., Das, R. & Bonneau, R., Jul 15 2013, In : PloS one. 8, 7, e67051.

    Research output: Contribution to journalArticle

    Amphiphilic cyclic peptoids that exhibit antimicrobial activity by disrupting Staphylococcus aureus membranes

    Huang, M. L., Benson, M. A., Shin, S. B. Y., Torres, V. J. & Kirshenbaum, K., Jun 1 2013, In : European Journal of Organic Chemistry. 17, p. 3560-3566 7 p.

    Research output: Contribution to journalArticle

    Chemoselective fragment condensation between peptide and peptidomimetic oligomers

    Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Jul 7 2013, In : Organic and Biomolecular Chemistry. 11, 25, p. 4142-4146 5 p.

    Research output: Contribution to journalArticle

    Peptoid nanotubes: An oligomer macrocycle that reversibly sequesters water via single-crystal-to-single-crystal transformations

    Vollrath, S. B. L., Hu, C., Bräse, S. & Kirshenbaum, K., Feb 21 2013, In : Chemical Communications. 49, 23, p. 2317-2319 3 p.

    Research output: Contribution to journalArticle

    2012

    A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents

    Huang, M. L., Shin, S. B. Y., Benson, M. A., Torres, V. J. & Kirshenbaum, K., Jan 2 2012, In : ChemMedChem. 7, 1, p. 114-122 9 p.

    Research output: Contribution to journalArticle

    Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells

    Levine, P. M., Lee, E., Greenfield, A., Bonneau, R., Logan, S. K., Garabedian, M. J. & Kirshenbaum, K., Oct 19 2012, In : ACS Chemical Biology. 7, 10, p. 1693-1701 9 p.

    Research output: Contribution to journalArticle

    Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments

    Hom, N., Mehta, K. R., Chou, T., Foraker, A. B., Brodsky, F. M., Kirshenbaum, K. & Montclare, J. K., Nov 28 2012, In : Journal of Materials Chemistry. 22, 44, p. 23335-23339 5 p.

    Research output: Contribution to journalArticle

    Biomimetic peptoid oligomers as dual-action antifreeze agents

    Huang, M. L., Ehre, D., Jiang, Q., Hu, C., Kirshenbaum, K. & Ward, M. D., Dec 4 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 19922-19927 6 p.

    Research output: Contribution to journalArticle

    De novo structure prediction and experimental characterization of folded peptoid oligomers

    Butterfoss, G. L., Yoo, B., Jaworski, J. N., Chorny, I., Dill, K. A., Zuckermann, R. N., Bonneau, R., Kirshenbaum, K. & Voelz, V. A., Sep 4 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 36, p. 14320-14325 6 p.

    Research output: Contribution to journalArticle

    Multivalent peptidomimetic conjugates: A versatile platform for modulating androgen receptor activity

    Levine, P. M., Imberg, K., Garabedian, M. J. & Kirshenbaum, K., Apr 25 2012, In : Journal of the American Chemical Society. 134, 16, p. 6912-6915 4 p.

    Research output: Contribution to journalArticle

    N-Naphthyl peptoid foldamers exhibiting atropisomerism

    Paul, B., Butterfoss, G. L., Boswell, M. G., Huang, M. L., Bonneau, R., Wolf, C. & Kirshenbaum, K., Feb 3 2012, In : Organic Letters. 14, 3, p. 926-929 4 p.

    Research output: Contribution to journalArticle

    Twice tied tight: Enforcing conformational order in bicyclic peptoid oligomers

    Vollrath, S. B. L., Bräse, S. & Kirshenbaum, K., Sep 1 2012, In : Chemical Science. 3, 9, p. 2726-2731 6 p.

    Research output: Contribution to journalArticle

    2011

    Modulation of human estrogen receptor α activity by multivalent estradiol-peptidomimetic conjugates

    Holub, J. M., Garabedian, M. J. & Kirshenbaum, K., Feb 1 2011, In : Molecular BioSystems. 7, 2, p. 337-345 9 p.

    Research output: Contribution to journalArticle

    Oligo(N-alkoxy glycines): trans substantiating peptoid conformations.

    Jordan, P. A., Paul, B., Butterfoss, G. L., Renfrew, P. D., Bonneau, R. & Kirshenbaum, K., 2011, In : Biopolymers. 96, 5, p. 617-626 10 p.

    Research output: Contribution to journalArticle

    Peptoid atropisomers

    Paul, B., Butterfoss, G. L., Boswell, M. G., Renfrew, P. D., Yeung, F. G., Shah, N. H., Wolf, C., Bonneau, R. & Kirshenbaum, K., Jul 20 2011, In : Journal of the American Chemical Society. 133, 28, p. 10910-10919 10 p.

    Research output: Contribution to journalArticle

    Student-driven design of peptide mimetics: Microwave-assisted synthesis of peptoid oligomers

    Pohl, N. L. B., Kirshenbaum, K., Yoo, B., Schulz, N., Zea, C. J., Streff, J. M. & Schwarz, K. L., Jul 1 2011, In : Journal of Chemical Education. 88, 7, p. 999-1001 3 p.

    Research output: Contribution to journalArticle

    2010

    Rapid multistep synthesis of a bioactive peptidomimetic oligomer for the undergraduate laboratory

    Utku, Y., Rohatgi, A., Yoo, B., Kirshenbaum, K., Zuckermann, R. N. & Pohl, N. L., Aug 27 2010, In : Journal of Chemical Education. 87, 6, p. 637-639 3 p.

    Research output: Contribution to journalArticle

    Tricks with clicks: modification of peptidomimetic oligomers via copper-catalyzed azide-alkyne [3 + 2] cycloaddition

    Holub, J. M. & Kirshenbaum, K., Mar 22 2010, In : Chemical Society Reviews. 39, 4, p. 1325-1337 13 p.

    Research output: Contribution to journalArticle

    2009

    A preliminary survey of the peptoid folding landscape

    Butterfoss, G. L., Renfrew, P. D., Kuhlman, B., Kirshenbaum, K. & Bonneau, R., Nov 27 2009, In : Journal of the American Chemical Society. 131, 46, p. 16798-16807 10 p.

    Research output: Contribution to journalArticle

    Folded biomimetic oligomers for enantioselective catalysis

    Maayan, G., Ward, M. D. & Kirshenbaum, K., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 13679-13684 6 p.

    Research output: Contribution to journalArticle

    Metallopeptoids

    Maayan, G., Ward, M. D. & Kirshenbaum, K., 2009, In : Chemical Communications. 1, p. 56-58 3 p.

    Research output: Contribution to journalArticle

    Peptide cyclization and cyclodimerization by Cu I-mediated azide-alkyne cycloaddition

    Jagasia, R., Holub, J. M., Bollinger, M., Kirshenbaum, K. & Finn, M. G., Apr 17 2009, In : Journal of Organic Chemistry. 74, 8, p. 2964-2974 11 p.

    Research output: Contribution to journalArticle

    2008

    Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands

    Maayan, G., Yoo, B. & Kirshenbaum, K., Jan 7 2008, In : Tetrahedron Letters. 49, 2, p. 335-338 4 p.

    Research output: Contribution to journalArticle

    Oligo(N-aryl glycines): A new twist on structured peptoids

    Shah, N. H., Butterfoss, G. L., Nguyen, K., Yoo, B., Bonneau, R., Rabenstein, D. L. & Kirshenbaum, K., Dec 10 2008, In : Journal of the American Chemical Society. 130, 49, p. 16622-16632 11 p.

    Research output: Contribution to journalArticle

    Photoresponsive peptoid oligomers bearing azobenzene side chains

    Shah, N. H. & Kirshenbaum, K., Jul 14 2008, In : Organic and Biomolecular Chemistry. 6, 14, p. 2516-2521 6 p.

    Research output: Contribution to journalArticle

    2007

    Characterizing the structure and dynamics of folded oligomers: Pulsed ESR studies of peptoid helices

    Fafarman, A. T., Borbat, P. P., Freed, J. H. & Kirshenbaum, K., Jan 1 2007, In : Chemical Communications. 4, p. 377-379 3 p.

    Research output: Contribution to journalArticle

    Conformational rearrangements by water-soluble peptoid foldamers

    Shin, S. B. Y. & Kirshenbaum, K., Nov 22 2007, In : Organic Letters. 9, 24, p. 5003-5006 4 p.

    Research output: Contribution to journalArticle