Kent Kirshenbaum

2025

In Vivo Efficacy of a Macrocyclic Peptoid-Peptide Hybrid That Selectively Modulates the Beta-Catenin/TCF Interaction to Inhibit Prostate Cancer

Habault, J., Franco, J. L., Ha, S., Schneider, J. A., Voisin, M., Wise, D. R., Wong, K. K., Garabedian, M. J., Kirshenbaum, K. & Logan, S. K., May 15 2025, In: Prostate. 85, 7, p. 646-658 13 p.

Research output: Contribution to journal › Article › peer-review

2024

Enhancing molecular diversity of peptoid oligomers using amino acid synthons

Smith, P. T., Franco, J. L. & Kirshenbaum, K., Dec 12 2024, In: Organic and Biomolecular Chemistry. 23, 5, p. 1175-1183 9 p.

Research output: Contribution to journal › Article › peer-review

2023

A Multivalent Peptoid Conjugate Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-resistant Prostate Cancer

Habault, J., Schneider, J. A., Ha, S., Ruoff, R., Pereira, L. D., Puccini, J., Ranieri, M., Ayasun, R., Deng, J., Kasper, A. C., Bar-Sagi, D., Wong, K. K., Zoubeidi, A., Claessens, F., Wise, D. R., Logan, S. K., Kirshenbaum, K. & Garabedian, M. J., Oct 1 2023, In: Molecular Cancer Therapeutics. 22, 10, p. 1166-1181 16 p.

Research output: Contribution to journal › Article › peer-review

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity

Tate, P. M., Mastrodomenico, V., Cunha, C., McClure, J., Barron, A. E., Diamond, G., Mounce, B. C. & Kirshenbaum, K., Aug 11 2023, In: ACS Infectious Diseases. 9, 8, p. 1508-1522 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Water-Soluble Chiral Cyclic Peptoids and Their Sodium and Gadolinium Complexes: Study of Conformational and Relaxometric Properties

D'Amato, A., Jiang, L., Della Sala, G., Kirshenbaum, K., Costabile, C., Furlan, C., Gianolio, E., Izzo, I. & De Riccardis, F., Jun 2 2023, In: Journal of Organic Chemistry. 88, 11, p. 6588-6598 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Evaluating the Conformations and Dynamics of Peptoid Macrocycles

Eastwood, J. R. B., Jiang, L., Bonneau, R., Kirshenbaum, K. & Renfrew, P. D., Jul 21 2022, In: Journal of Physical Chemistry B. 126, 28, p. 5161-5174 14 p.

Research output: Contribution to journal › Article › peer-review

Programmed Supramolecular Assemblies Using Orthogonal Pairs of Heterodimeric Coiled Coil Peptides

Jiang, L., Zuo, X., Li, J., Traaseth, N. J. & Kirshenbaum, K., Jul 4 2022, In: Angewandte Chemie - International Edition. 61, 27, e202201895.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Elaborate supramolecular architectures formed by co-assembly of metal species and peptoid macrocycles

Jiang, L., Hu, C. T., De Riccardis, F. & Kirshenbaum, K., Jul 7 2021, In: Crystal Growth and Design. 21, 7, p. 3889-3901 13 p.

Research output: Contribution to journal › Article › peer-review

2020

A modular approach for organizing dimeric coiled coils on peptoid oligomer scaffolds

Jiang, L. & Kirshenbaum, K., Mar 28 2020, In: Organic and Biomolecular Chemistry. 18, 12, p. 2312-2320 9 p.

Research output: Contribution to journal › Article › peer-review

Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets

Kim, J. H., Kim, S. C., Kline, M. A., Grzincic, E. M., Tresca, B. W., Cardiel, J., Karbaschi, M., Dehigaspitiya, D. C., Chen, Y., Udumula, V., Jian, T., Murray, D. J., Yun, L., Connolly, M. D., Liu, J., Ren, G., Chen, C. L., Kirshenbaum, K., Abate, A. R. & Zuckermann, R. N., Jan 28 2020, In: ACS nano. 14, 1, p. 185-195 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Holographic immunoassays: Direct detection of antibodies binding to colloidal spheres

Snyder, K., Quddus, R., Hollingsworth, A. D., Kirshenbaum, K. & Grier, D. G., Nov 28 2020, In: Soft Matter. 16, 44, p. 10180-10186 7 p.

Research output: Contribution to journal › Article › peer-review

Optimization of Protocols for Detection of de Novo Protein Synthesis in Whole Blood Samples via Azide-Alkyne Cycloaddition

Bowling, H. L., Kasper, A., Patole, C., Venkatasubramani, J. P., Leventer, S. P., Carmody, E., Sharp, K., Berry-Kravis, E., Kirshenbaum, K., Klann, E. & Bhattacharya, A., Sep 4 2020, In: Journal of Proteome Research. 19, 9, p. 3856-3866 11 p.

Research output: Contribution to journal › Article › peer-review

Self-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation

Yuan, X., Jiang, L., Chen, W., Song, B., Chen, W., Zuo, X., Sun, X., Li, X., Kirshenbaum, K., Luo, S. & Dong, H., Jul 4 2020, In: Chemical Communications. 56, 52, p. 7128-7131 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T. A. & Klann, E., Dec 1 2019, In: Nature communications. 10, 1, 1710.

Research output: Contribution to journal › Article › peer-review

Open Access

Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP ^Sc and Targeting PrP ^Sc for Lysosomal Degradation

Pankiewicz, J. E., Sanchez, S., Kirshenbaum, K., Kascsak, R. B., Kascsak, R. J. & Sadowski, M. J., Mar 1 2019, In: Molecular Neurobiology. 56, 3, p. 2073-2091 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Implementing Efficient Peptoid-Mediated Delivery of RNA-Based Therapeutics to the Vocal Folds

Mukudai, S., Kraja, I., Bing, R., Nalband, D. M., Tatikola, M., Hiwatashi, N., Kirshenbaum, K. & Branski, R. C., Dec 1 2019, In: Laryngoscope investigative otolaryngology. 4, 6, p. 640-644 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

Schneider, J. A., Craven, T. W., Kasper, A. C., Yun, C., Haugbro, M., Briggs, E. M., Svetlov, V., Nudler, E., Knaut, H., Bonneau, R., Garabedian, M. J., Kirshenbaum, K. & Logan, S. K., Dec 1 2018, In: Nature communications. 9, 1, 4396.

Research output: Contribution to journal › Article › peer-review

Open Access

Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition

Battigelli, A., Kim, J. H., Dehigaspitiya, D. C., Proulx, C., Robertson, E. J., Murray, D. J., Rad, B., Kirshenbaum, K. & Zuckermann, R. N., Mar 27 2018, In: ACS nano. 12, 3, p. 2455-2465 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

Andreev, K., Martynowycz, M. W., Huang, M. L., Kuzmenko, I., Bu, W., Kirshenbaum, K. & Gidalevitz, D., Jun 2018, In: Biochimica et Biophysica Acta - Biomembranes. 1860, 6, p. 1414-1423 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Nanoparticle delivery of RNA-based therapeutics to alter the vocal fold tissue response to injury

Hiwatashi, N., Kraja, I., Benedict, P. A., Dion, G. R., Bing, R., Rousseau, B., Amin, M. R., Nalband, D. M., Kirshenbaum, K. & Branski, R. C., May 2018, In: Laryngoscope. 128, 5, p. E178-E183

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts

Kraja, I., Bing, R., Hiwatashi, N., Rousseau, B., Nalband, D., Kirshenbaum, K. & Branski, R. C., Jul 2017, In: Laryngoscope. 127, 7, p. E231-E237

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A Miniature Protein Stabilized by a Cation-π Interaction Network

Craven, T. W., Cho, M. K., Traaseth, N. J., Bonneau, R. & Kirshenbaum, K., Feb 17 2016, In: Journal of the American Chemical Society. 138, 5, p. 1543-1550 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

BONLAC: A combinatorial proteomic technique to measure stimulus-induced translational profiles in brain slices

Bowling, H., Bhattacharya, A., Zhang, G., Lebowitz, J. Z., Alam, D., Smith, P. T., Kirshenbaum, K., Neubert, T. A., Vogel, C., Chao, M. V. & Klann, E., Jan 1 2016, In: Neuropharmacology. 100, p. 76-89 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cyclization Improves Membrane Permeation by Antimicrobial Peptoids

Andreev, K., Martynowycz, M. W., Ivankin, A., Huang, M. L., Kuzmenko, I., Meron, M., Lin, B., Kirshenbaum, K. & Gidalevitz, D., Dec 6 2016, In: Langmuir. 32, 48, p. 12905-12913 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Multivalent peptoid conjugates which overcome enzalutamide resistance in prostate cancer cells

Wang, Y., Dehigaspitiya, D. C., Levine, P. M., Profit, A. A., Haugbro, M., Imberg-Kazdan, K., Logan, S. K., Kirshenbaum, K. & Garabedian, M. J., Sep 1 2016, In: Cancer Research. 76, 17, p. 5124-5132 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

PPII Helical Peptidomimetics Templated by Cation–π Interactions

Craven, T. W., Bonneau, R. & Kirshenbaum, K., Oct 4 2016, In: ChemBioChem. p. 1824-1828 5 p.

Research output: Contribution to journal › Article › peer-review

2015

Osmoprotective polymer additives attenuate the membrane pore-forming activity of antimicrobial peptoids

Smith, P. T., Huang, M. L. & Kirshenbaum, K., Apr 1 2015, In: Biopolymers. 103, 4, p. 227-236 10 p.

Research output: Contribution to journal › Article › peer-review

2014

A rotamer library to enable modeling and design of peptoid foldamers

Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Kirshenbaum, K. & Bonneau, R., Jun 18 2014, In: Journal of the American Chemical Society. 136, 24, p. 8772-8782 11 p.

Research output: Contribution to journal › Article › peer-review

Conformational preferences of Peptide - Peptoid hybrid oligomers

Butterfoss, G. L., Drew, K., Renfrew, P. D., Kirshenbaum, K. & Bonneau, R., Sep 1 2014, In: Biopolymers - Peptide Science Section. 102, 5, p. 369-378 10 p.

Research output: Contribution to journal › Article › peer-review

In-depth quantitative proteomic analysis of de novo protein synthesis induced by brain-derived neurotrophic factor

Zhang, G., Bowling, H., Hom, N., Kirshenbaum, K., Klann, E., Chao, M. V. & Neubert, T. A., Dec 5 2014, In: Journal of Proteome Research. 13, 12, p. 5707-5714 8 p.

Research output: Contribution to journal › Article › peer-review

Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine

Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Jun 3 2014, In: Chemical Communications. 50, 52, p. 6909-6912 4 p.

Research output: Contribution to journal › Article › peer-review

Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: Physical characterization and biological activity

Konca, Y. U., Kirshenbaum, K. & Zuckermann, R. N., May 10 2014, In: International Journal of Nanomedicine. 9, 1, p. 2271-2285 15 p.

Research output: Contribution to journal › Article › peer-review

Rapid identification of metal-binding peptoid oligomers by on-resin x-ray fluorescence screening

Nalband, D. M., Warner, B. P., Zahler, N. H. & Kirshenbaum, K., Sep 1 2014, In: Biopolymers - Peptide Science Section. 102, 5, p. 407-415 9 p.

Research output: Contribution to journal › Article › peer-review

Semisynthesis of peptoid-protein hybrids by chemical ligation at serine

Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Jan 17 2014, In: Organic Letters. 16, 2, p. 512-515 4 p.

Research output: Contribution to journal › Article › peer-review

Targeting the androgen receptor with steroid conjugates

Levine, P. M., Garabedian, M. J. & Kirshenbaum, K., Oct 23 2014, In: Journal of Medicinal Chemistry. 57, 20, p. 8224-8237 14 p.

Research output: Contribution to journal › Article › peer-review

2013

Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design

Drew, K., Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Chou, F. C., Lyskov, S., Bullock, B. N., Watkins, A., Labonte, J. W., Pacella, M., Kilambi, K. P., Leaver-Fay, A., Kuhlman, B., Gray, J. J., Bradley, P., Kirshenbaum, K., Arora, P. S., Das, R. & Bonneau, R., Jul 15 2013, In: PloS one. 8, 7, e67051.

Research output: Contribution to journal › Article › peer-review

Amphiphilic cyclic peptoids that exhibit antimicrobial activity by disrupting Staphylococcus aureus membranes

Huang, M. L., Benson, M. A., Shin, S. B. Y., Torres, V. J. & Kirshenbaum, K., Jun 2013, In: European Journal of Organic Chemistry. 17, p. 3560-3566 7 p.

Research output: Contribution to journal › Article › peer-review

Chemoselective fragment condensation between peptide and peptidomimetic oligomers

Levine, P. M., Craven, T. W., Bonneau, R. & Kirshenbaum, K., Jul 7 2013, In: Organic and Biomolecular Chemistry. 11, 25, p. 4142-4146 5 p.

Research output: Contribution to journal › Article › peer-review

Peptoid nanotubes: An oligomer macrocycle that reversibly sequesters water via single-crystal-to-single-crystal transformations

Vollrath, S. B. L., Hu, C., Bräse, S. & Kirshenbaum, K., Feb 21 2013, In: Chemical Communications. 49, 23, p. 2317-2319 3 p.

Research output: Contribution to journal › Article › peer-review

2012

A comparison of linear and cyclic peptoid oligomers as potent antimicrobial agents

Huang, M. L., Shin, S. B. Y., Benson, M. A., Torres, V. J. & Kirshenbaum, K., Jan 2 2012, In: ChemMedChem. 7, 1, p. 114-122 9 p.

Research output: Contribution to journal › Article › peer-review

Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells

Levine, P. M., Lee, E., Greenfield, A., Bonneau, R., Logan, S. K., Garabedian, M. J. & Kirshenbaum, K., Oct 19 2012, In: ACS Chemical Biology. 7, 10, p. 1693-1701 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments

Hom, N., Mehta, K. R., Chou, T., Foraker, A. B., Brodsky, F. M., Kirshenbaum, K. & Montclare, J. K., Nov 28 2012, In: Journal of Materials Chemistry. 22, 44, p. 23335-23339 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Biomimetic peptoid oligomers as dual-action antifreeze agents

Huang, M. L., Ehre, D., Jiang, Q., Hu, C., Kirshenbaum, K. & Ward, M. D., Dec 4 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 19922-19927 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

De novo structure prediction and experimental characterization of folded peptoid oligomers

Butterfoss, G. L., Yoo, B., Jaworski, J. N., Chorny, I., Dill, K. A., Zuckermann, R. N., Bonneau, R., Kirshenbaum, K. & Voelz, V. A., Sep 4 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 36, p. 14320-14325 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

Kent Kirshenbaum

Research output

Search results