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Lionel Christiaen

Associate Professor of Biology

    20022019

    Research output per year

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    Research Output

    2019

    A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory

    Athanasiadou, R., Neymotin, B., Brandt, N., Wang, W., Christiaen, L., Gresham, D. & Tranchina, D., Mar 2019, In : PLoS computational biology. 15, 3, e1006794.

    Research output: Contribution to journalArticle

    Open Access

    A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

    Prummel, K. D., Hess, C., Nieuwenhuize, S., Parker, H. J., Rogers, K. W., Kozmikova, I., Racioppi, C., Brombacher, E. C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M. H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M. & 2 others, Krumlauf, R. & Mosimann, C., Dec 1 2019, In : Nature communications. 10, 1, 3857.

    Research output: Contribution to journalArticle

    Open Access

    A single-cell transcriptional roadmap for cardiopharyngeal fate diversification

    Wang, W., Niu, X., Stuart, T., Jullian, E., Mauck, W. M., Kelly, R. G., Satija, R. & Christiaen, L., Jun 1 2019, In : Nature Cell Biology. 21, 6, p. 674-686 13 p.

    Research output: Contribution to journalArticle

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Racioppi, C., Wiechecki, K. A. & Christiaen, L., Nov 2019, In : eLife. 8, e49921.

    Research output: Contribution to journalArticle

    Open Access

    Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

    Bernadskaya, Y. Y., Brahmbhatt, S., Gline, S. E., Wang, W. & Christiaen, L., Dec 1 2019, In : Nature communications. 10, 1, 57.

    Research output: Contribution to journalArticle

    Initial characterization of Wnt-Tcf functions during Ciona heart development

    Kaplan, N. A., Wang, W. & Christiaen, L., Apr 15 2019, In : Developmental Biology. 448, 2, p. 199-209 11 p.

    Research output: Contribution to journalArticle

    Transcriptional regulation of Rab32/38, a specific marker of pigment cell formation in Ciona robusta

    Racioppi, C., Coppola, U., Christiaen, L. & Ristoratore, F., Apr 15 2019, In : Developmental Biology. 448, 2, p. 111-118 8 p.

    Research output: Contribution to journalArticle

    2018

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Razy-Krajka, F., Gravez, B., Kaplan, N., Racioppi, C., Wang, W. & Christiaen, L., Feb 6 2018, In : eLife. 7, e29656.

    Research output: Contribution to journalArticle

    ANISEED 2017: Extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets

    Brozovic, M., Dantec, C., Dardaillon, J., Dauga, D., Faure, E., Gineste, M., Louis, A., Naville, M., Nitta, K. R., Piette, J., Reeves, W., Scornavacca, C., Simion, P., Vincentelli, R., Bellec, M., Aicha, S. B., Fagotto, M., Guéroult-Bellone, M., Haeussler, M., Jacox, E. & 19 others, Lowe, E. K., Mendez, M., Roberge, A., Stolfi, A., Yokomori, R., Brown, C. T., Cambillau, C., Christiaen, L., Delsuc, F., Douzery, E., Dumollard, R., Kusakabe, T., Nakai, K., Nishida, H., Satou, Y., Swalla, B., Veeman, M., Volff, J. N. & Lemaire, P., Jan 1 2018, In : Nucleic acids research. 46, D1, p. D718-D725

    Research output: Contribution to journalArticle

    CRISPR knockouts in Ciona embryos

    Gandhi, S., Razy-Krajka, F., Christiaen, L. & Stolfi, A., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 141-152 12 p. (Advances in Experimental Medicine and Biology; vol. 1029).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Purification of fluorescent labeled cells from dissociated Ciona embryos

    Wang, W., Racioppi, C., Gravez, B. & Christiaen, L., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 101-107 7 p. (Advances in Experimental Medicine and Biology; vol. 1029).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2017

    Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona

    Gandhi, S., Haeussler, M., Razy-Krajka, F., Christiaen, L. & Stolfi, A., May 1 2017, In : Developmental Biology. 425, 1, p. 8-20 13 p.

    Research output: Contribution to journalArticle

    Evolutionary loss of melanogenesis in the tunicate Molgula occulta

    Racioppi, C., Valoroso, M. C., Coppola, U., Lowe, E. K., Brown, C. T., Swalla, B. J., Christiaen, L., Stolfi, A. & Ristoratore, F., Jul 18 2017, In : EvoDevo. 8, 1, 11.

    Research output: Contribution to journalArticle

    Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

    Burguera, D., Marquez, Y., Racioppi, C., Permanyer, J., Torres-Méndez, A., Esposito, R., Albuixech-Crespo, B., Fanlo, L., D'Agostino, Y., Gohr, A., Navas-Perez, E., Riesgo, A., Cuomo, C., Benvenuto, G., Christiaen, L. A., Martí, E., D'Aniello, S., Spagnuolo, A., Ristoratore, F., Arnone, M. I. & 2 others, Garcia-Fernàndez, J. & Irimia, M., Dec 1 2017, In : Nature communications. 8, 1, 1799.

    Research output: Contribution to journalArticle

    2016

    Fused Regression for Multi-source Gene Regulatory Network Inference

    Lam, K. Y., Westrick, Z. M., Müller, C. L., Christiaen, L. & Bonneau, R., Dec 2016, In : PLoS computational biology. 12, 12, e1005157.

    Research output: Contribution to journalArticle

    Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages

    Tolkin, T. & Christiaen, L., Oct 15 2016, In : Development (Cambridge). 143, 20, p. 3852-3862 11 p.

    Research output: Contribution to journalArticle

    Transcriptional Control of Developmental Cell Behaviors

    Bernadskaya, Y. & Christiaen, L., Oct 6 2016, In : Annual Review of Cell and Developmental Biology. 32, p. 77-101 25 p.

    Research output: Contribution to journalReview article

    2015

    A new heart for a new head in vertebrate cardiopharyngeal evolution

    Diogo, R., Kelly, R. G., Christiaen, L., Levine, M., Ziermann, J. M., Molnar, J. L., Noden, D. M. & Tzahor, E., Apr 23 2015, In : Nature. 520, 7548, p. 466-473 8 p.

    Research output: Contribution to journalReview article

    Guidelines for the nomenclature of genetic elements in tunicate genomes

    Stolfi, A., Sasakura, Y., Chalopin, D., Satou, Y., Christiaen, L., Dantec, C., Endo, T., Naville, M., Nishida, H., Swalla, B. J., Volff, J. N., Voskoboynik, A., Dauga, D. & Lemaire, P., Jan 1 2015, In : Genesis. 53, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

    Migratory neuronal progenitors arise from the neural plate borders in tunicates

    Stolfi, A., Ryan, K., Meinertzhagen, I. A. & Christiaen, L., Nov 19 2015, In : Nature. 527, 7578, p. 371-374 4 p.

    Research output: Contribution to journalArticle

    Regulation and evolution of cardiopharyngeal cell identity and behavior: Insights from simple chordates

    Kaplan, N., Razy-Krajka, F. & Christiaen, L., Jun 1 2015, In : Current Opinion in Genetics and Development. 32, p. 119-128 10 p.

    Research output: Contribution to journalReview article

    Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration

    Gline, S., Kaplan, N., Bernadskaya, Y., Abdu, Y. & Christiaen, L., Feb 1 2015, In : Development (Cambridge). 142, 3, p. 544-554 11 p.

    Research output: Contribution to journalArticle

    2014

    Collier/OLF/EBF-Dependent Transcriptional Dynamics Control Pharyngeal Muscle Specification from Primed Cardiopharyngeal Progenitors

    Razy-Krajka, F., Lam, K., Wang, W., Stolfi, A., Joly, M., Bonneau, R. & Christiaen, L., May 12 2014, In : Developmental Cell. 29, 3, p. 263_276

    Research output: Contribution to journalArticle

    Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians

    Stolfi, A., Lowe, E. K., Racioppi, C., Ristoratore, F., Brown, C. T., Swalla, B. J. & Christiaen, L., Jan 1 2014, In : eLife. 3, p. e03728

    Research output: Contribution to journalArticle

    Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

    Racioppi, C., Kamal, A. K., Razy-Krajka, F., Gambardella, G., Zanetti, L., Di Bernardo, D., Sanges, R., Christiaen, L. A. & Ristoratore, F., 2014, In : Nature communications. 5, 5830.

    Research output: Contribution to journalArticle

    Tissue-specific genome editing in ciona embryos by CRISPR/Cas9

    Stolfi, A., Gandhi, S., Salek, F. & Christiaen, L., Nov 1 2014, In : Development (Cambridge). 141, 21, p. 4115-4120 6 p.

    Research output: Contribution to journalArticle

    2013

    Cis-Regulatory Timers for Developmental Gene Expression

    Christiaen, L., Nov 1 2013, In : PLoS biology. 11, 10, e1001698.

    Research output: Contribution to journalArticle

    NK4 Antagonizes Tbx1/10 to Promote Cardiac versus Pharyngeal Muscle Fate in the Ascidian Second Heart Field

    Wang, W., Razy-Krajka, F., Siu, E., Ketcham, A. & Christiaen, L., Dec 1 2013, In : PLoS biology. 11, 12, e1001725.

    Research output: Contribution to journalArticle

    p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos

    Haupaix, N., Stolfi, A., Sirour, C., Picco, V., Levine, M., Christiaen, L. & Yasuo, H., Nov 1 2013, In : Development (Cambridge). 140, 21, p. 4347-4352 6 p.

    Research output: Contribution to journalArticle

    2012

    Developmental cell behavior

    Christiaen, L., May 2012, In : Seminars in Cell and Developmental Biology. 23, 3, 1 p.

    Research output: Contribution to journalEditorial

    Development and Evolution of the Ascidian Cardiogenic Mesoderm

    Tolkin, T. & Christiaen, L., 2012, Current Topics in Developmental Biology. Academic Press Inc., p. 107-142 36 p. (Current Topics in Developmental Biology; vol. 100).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Genetic and genomic toolbox of the Chordate Ciona intestinalis

    Stolfi, A. & Christiaen, L., Sep 1 2012, In : Genetics. 192, 1, p. 55-66 12 p.

    Research output: Contribution to journalReview article

    Transcriptional Enhancers in Ascidian Development

    Wang, W. & Christiaen, L., 2012, In : Current Topics in Developmental Biology. 98, p. 147-172 26 p.

    Research output: Contribution to journalArticle

    2010

    A cis-regulatory signature for chordate anterior neuroectodermal genes

    Haeussler, M., Jaszczyszyn, Y., Christiaen, L. & Joly, J. S., Apr 1 2010, In : PLoS genetics. 6, 4

    Research output: Contribution to journalArticle

    BMP signaling coordinates gene expression and cell migration during precardiac mesoderm development

    Christiaen, L., Stolfi, A. & Levine, M., Apr 2010, In : Developmental Biology. 340, 2, p. 179-187 9 p.

    Research output: Contribution to journalArticle

    Early chordate origins of the vertebrate second heart field

    Stolfi, A., Gainous, T. B., Young, J. J., Mori, A., Levine, M. & Christiaen, L., Jul 30 2010, In : Science. 329, 5991, p. 565-568 4 p.

    Research output: Contribution to journalArticle

    The ANISEED database: Digital representation, formalization, and elucidation of a chordate developmental program

    Tassy, O., Dauga, D., Daian, F., Sobral, D., Robin, F., Khoueiry, P., Salgado, D., Fox, V., Caillol, D., Schiappa, R., Laporte, B., Rios, A., Luxardi, G., Kusakabe, T., Joly, J. S., Darras, S., Christiaen, L., Contensin, M., Auger, H., Lamy, C. & 9 others, Hudson, C., Rothbächer, U., Gilchrist, M. J., Makabe, K. W., Hotta, K., Fujiwara, S., Satoh, N., Satou, Y. & Lemaire, P., Oct 2010, In : Genome Research. 20, 10, p. 1459-1468 10 p.

    Research output: Contribution to journalArticle

    2009

    Electroporation of transgenic DNAs in the sea squirt Ciona

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Isolation of sea squirt (Ciona) gametes, fertilization, dechorionation, and development

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Microinjection of morpholino oligos and RNAs in sea squirt (Ciona) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp

    Christiaen, L., Stolfi, A., Davidson, B. & Levine, M., Apr 15 2009, In : Developmental Biology. 328, 2, p. 552-560 9 p.

    Research output: Contribution to journalArticle

    The sea squirt Ciona intestinalis

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    Whole-mount in situ hybridization on sea squirt (Ciona intestinalis) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    X-gal staining of electroporated sea squirt (Ciona) embryos

    Christiaen, L., Wagner, E., Shi, W. & Levine, M., Dec 22 2009, In : Cold Spring Harbor Protocols. 4, 12

    Research output: Contribution to journalArticle

    2008

    The transcription/migration interface in heart precursors of Ciona intestinalis

    Christiaen, L., Davidson, B., Kawashima, T., Powell, W., Nolla, H., Vranizan, K. & Levine, M., Jun 6 2008, In : Science. 320, 5881, p. 1349-1352 4 p.

    Research output: Contribution to journalArticle

    2007

    Evolutionary modification of mouth position in deuterostomes

    Christiaen, L., Jaszczyszyn, Y., Kerfant, M., Kano, S., Thermes, V. & Joly, J. S., Aug 2007, In : Seminars in Cell and Developmental Biology. 18, 4, p. 502-511 10 p.

    Research output: Contribution to journalReview article

    FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis

    Beh, J., Shi, W., Levine, M., Davidson, B. & Christiaen, L., Sep 1 2007, In : Development. 134, 18, p. 3297-3305 9 p.

    Research output: Contribution to journalArticle

    2006

    FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis

    Davidson, B., Shi, W., Beh, J., Christiaen, L. & Levine, M., Oct 1 2006, In : Genes and Development. 20, 19, p. 2728-2738 11 p.

    Research output: Contribution to journalArticle

    Linking chordate gene networks to cellular behavior in ascidians

    Davidson, B. & Christiaen, L., Jan 27 2006, In : Cell. 124, 2, p. 247-250 4 p.

    Research output: Contribution to journalShort survey