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Nicholas Geacintov

Professor of Chemistry

    1960 …2020

    Research output per year

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    Research Output

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    2020

    Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B

    Kolbanovskiy, M., Shim, Y., Min, J. H., Geacintov, N. E. & Shafirovich, V., May 12 2020, In : Biochemistry. 59, 18, p. 1728-1736 9 p.

    Research output: Contribution to journalArticle

    2019

    5-Formylcytosine-induced DNA–peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells

    Ji, S., Park, D., Kropachev, K., Kolbanovskiy, M., Fu, I., Broyde, S., Essawy, M., Geacintov, N. E. & Tretyakova, N. Y., Nov 29 2019, In : Journal of Biological Chemistry. 294, 48, p. 18387-18397 11 p.

    Research output: Contribution to journalArticle

    Excision of Oxidatively Generated Guanine Lesions by Competing Base and Nucleotide Excision Repair Mechanisms in Human Cells

    Shafirovich, V., Kropachev, K., Kolbanovskiy, M. & Geacintov, N. E., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 753-761 9 p.

    Research output: Contribution to journalArticle

    Generation of 8-oxo-7,8-dihydroguanine in G-Quadruplexes Models of Human Telomere Sequences by One-electron Oxidation

    Merta, T. J., Geacintov, N. E. & Shafirovich, V., Jan 1 2019, In : Photochemistry and photobiology. 95, 1, p. 244-251 8 p.

    Research output: Contribution to journalArticle

    Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

    Shafirovich, V., Kolbanovskiy, M., Kropachev, K., Liu, Z., Cai, Y., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Amin, S., Dadali, A., Broyde, S. & Geacintov, N. E., Feb 12 2019, In : Biochemistry. 58, 6, p. 561-574 14 p.

    Research output: Contribution to journalArticle

    2018

    Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli

    Zutterling, C., Mursalimov, A., Talhaoui, I., Koshenov, Z., Akishev, Z., Bissenbaev, A. K., Mazon, G., Geacintov, N. E., Gasparutto, D., Groisman, R., Zharkov, D. O., Matkarimov, B. T. & Saparbaev, M., Jan 1 2018, In : PeerJ. 2018, 12, e6029.

    Research output: Contribution to journalArticle

    Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

    Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, Gorgoulis, V. G., Mar 16 2018, In : Genome biology. 19, 1, 37.

    Research output: Contribution to journalArticle

    2017

    Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase

    Rechkoblit, O., Kolbanovskiy, A., Landes, H., Geacintov, N. E. & Aggarwal, A. K., Dec 1 2017, In : Nature communications. 8, 1, 1013.

    Research output: Contribution to journalArticle

    The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro

    Kolbanovskiy, M., Chowdhury, M. A., Nadkarni, A., Broyde, S., Geacintov, N. E., Scicchitano, D. A. & Shafirovich, V., Jun 20 2017, In : Biochemistry. 56, 24, p. 3008-3018 11 p.

    Research output: Contribution to journalArticle

    2016

    Base and nucleotide excision repair of oxidatively generated guanine lesions in DNA

    Shafirovich, V., Kropachev, K., Anderson, T., Liu, Z., Kolbanovskiy, M., Martin, B. D., Sugden, K., Shim, Y., Chen, X., Min, J. H. & Geacintov, N. E., Mar 4 2016, In : Journal of Biological Chemistry. 291, 10, p. 5309-5319 11 p.

    Research output: Contribution to journalArticle

    Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro

    Purohit, N. K., Robu, M., Shah, R. G., Geacintov, N. E. & Shah, G. M., Jan 12 2016, In : Scientific reports. 6, 19020.

    Research output: Contribution to journalArticle

    Nucleotide excision repair and transcription-coupled DNA repair abrogate the impact of DNA damage on transcription

    Nadkarni, A., Burns, J. A., Gandolfi, A., Chowdhury, M. A., Cartularo, L., Berens, C., Geacintov, N. E. & Scicchitano, D. A., Jan 8 2016, In : Journal of Biological Chemistry. 291, 2, p. 848-861 14 p.

    Research output: Contribution to journalArticle

    Translesion synthesis past guanine(C8)-thymine(N3) intrastrand cross-links catalyzed by selected A- and Y-family polymerases

    Lee, Y. A., Lee, Y. C., Geacintov, N. E. & Shafirovich, V., Jan 1 2016, In : Molecular BioSystems. 12, 6, p. 1892-1900 9 p.

    Research output: Contribution to journalArticle

    2015

    Differences in the Access of Lesions to the Nucleotide Excision Repair Machinery in Nucleosomes

    Cai, Y., Kropachev, K., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Shafirovich, V., Geacintov, N. E. & Broyde, S., Jul 14 2015, In : Biochemistry. 54, 27, p. 4181-4185 5 p.

    Research output: Contribution to journalArticle

    DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes

    Cohen, I. S., Bar, C., Paz-Elizur, T., Ainbinder, E., Leopold, K., De Wind, N., Geacintov, N. & Livneh, Z., Jan 1 2015, In : Nucleic acids research. 43, 3, p. 1637-1645 9 p.

    Research output: Contribution to journalArticle

    DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells

    Shriber, P., Leitner-Dagan, Y., Geacintov, N., Paz-Elizur, T. & Livneh, Z., Oct 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 780, p. 71-76 6 p.

    Research output: Contribution to journalArticle

    Oxidatively generated guanine(C8)-Thymine(N3) intrastrand cross-links in double-stranded DNA are repaired by base excision repair pathways

    Talhaoui, I., Shafirovich, V., Liu, Z., Saint-Pierre, C., Akishev, Z., Matkarimov, B. T., Gasparutto, D., Geacintov, N. E. & Saparbaev, M., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14610-14617 8 p.

    Research output: Contribution to journalArticle

    Resistance to nucleotide excision repair of bulky guanine adducts opposite abasic sites in DNA duplexes and relationships between structure and function

    Liu, Z., Ding, S., Kropachev, K., Lei, J., Amin, S., Broyde, S. & Geacintov, N. E., Sep 4 2015, In : PloS one. 10, 9, e0137124.

    Research output: Contribution to journalArticle

    2014

    Benzo[a]pyrene-derived DNA lesions decrease DNA methylation by murine methyltransferase DNMT3A2

    Lukashevich, O. V., Cherepanova, N. A., Kolbanovsky, A., Geacintov, N. E. & Gromova, E. S., Mar 2014, In : Moscow University Chemistry Bulletin. 69, 2, p. 92-96 5 p.

    Research output: Contribution to journalArticle

    Generation of guanine-amino acid cross-links by a free radical combination mechanism

    Uvaydov, Y., Geacintov, N. E. & Shafirovich, V., Jun 21 2014, In : Physical Chemistry Chemical Physics. 16, 23, p. 11729-11736 8 p.

    Research output: Contribution to journalArticle

    Human DNA polymerases catalyze lesion bypass across benzo[a]pyrene-derived DNA adduct clustered with an abasic site

    Starostenko, L. V., Rechkunova, N. I., Lebedeva, N. A., Kolbanovskiy, A., Geacintov, N. E. & Lavrik, O. I., Dec 1 2014, In : DNA Repair. 24, p. 1-9 9 p.

    Research output: Contribution to journalArticle

    Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

    Ziv, O., Zeisel, A., Mirlas-Neisberg, N., Swain, U., Nevo, R., Ben-Chetrit, N., Martelli, M. P., Rossi, R., Schiesser, S., Canman, C. E., Carell, T., Geacintov, N. E., Falini, B., Domany, E. & Livneh, Z., 2014, In : Nature communications. 5, 5437.

    Research output: Contribution to journalArticle

    Mechanistic aspects of hydration of guanine radical cations in DNA

    Rokhlenko, Y., Cadet, J., Geacintov, N. E. & Shafirovich, V., Apr 23 2014, In : Journal of the American Chemical Society. 136, 16, p. 5956-5962 7 p.

    Research output: Contribution to journalArticle

    Nuclear magnetic resonance studies of an N 2-guanine adduct derived from the tumorigen dibenzo[ a, l ]pyrene in DNA: Impact of adduct stereochemistry, size, and local DNA sequence on solution conformations

    Rodríguez, F. A., Liu, Z., Lin, C. H., Ding, S., Cai, Y., Kolbanovskiy, A., Kolbanovskiy, M., Amin, S., Broyde, S. & Geacintov, N. E., Mar 25 2014, In : Biochemistry. 53, 11, p. 1827-1841 15 p.

    Research output: Contribution to journalArticle

    One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA

    Cadet, J., Wagner, J. R., Shafirovich, V. & Geacintov, N. E., Jun 2014, In : International Journal of Radiation Biology. 90, 6, p. 423-432 10 p.

    Research output: Contribution to journalArticle

    Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity

    Lior-Hoffmann, L., Ding, S., Geacintov, N. E., Zhang, Y. & Broyde, S., Sep 9 2014, In : Biochemistry. 53, 35, p. 5683-5691 9 p.

    Research output: Contribution to journalArticle

    Structural basis for the recognition of diastereomeric 5′,8-cyclo- 2′-deoxypurine lesions by the human nucleotide excision repair system

    Kropachev, K., Ding, S., Terzidis, M. A., Masi, A., Liu, Z., Cai, Y., Kolbanovskiy, M., Chatgilialoglu, C., Broyde, S., Geacintov, N. E. & Shafirovich, V., Apr 2014, In : Nucleic acids research. 42, 8, p. 5020-5032 13 p.

    Research output: Contribution to journalArticle

    The relationships between XPC binding to conformationally diverse DNA adducts and their excision by the human NER system: Is there a correlation?

    Lee, Y. C., Cai, Y., Mu, H., Broyde, S., Amin, S., Chen, X., Min, J. H. & Geacintov, N. E., Jul 2014, In : DNA Repair. 19, p. 55-63 9 p.

    Research output: Contribution to journalArticle

    2013

    Adenine-DNA adduct derived from the nitroreduction of 6-nitrochrysene is more resistant to nucleotide excision repair than guanine-DNA adducts

    Krzeminski, J., Kropachev, K., Reeves, D., Kolbanovskiy, A., Kolbanovskiy, M., Chen, K. M., Sharma, A. K., Geacintov, N., Amin, S. & El-Bayoumy, K., Nov 18 2013, In : Chemical research in toxicology. 26, 11, p. 1746-1754 9 p.

    Research output: Contribution to journalArticle

    Adenine-DNA adducts derived from the highly tumorigenic dibenzo[a,l]pyrene are resistant to nucleotide excision repair while guanine adducts are not

    Kropachev, K., Kolbanovskiy, M., Liu, Z., Cai, Y., Zhang, L., Schwaid, A. G., Kolbanovskiy, A., Ding, S., Amin, S., Broyde, S. & Geacintov, N. E., May 20 2013, In : Chemical research in toxicology. 26, 5, p. 783-793 11 p.

    Research output: Contribution to journalArticle

    Free energy profiles of base flipping in intercalative polycyclic aromatic hydrocarbon-damaged DNA duplexes: Energetic and structural relationships to nucleotide excision repair susceptibility

    Cai, Y., Zheng, H., Ding, S., Kropachev, K., Schwaid, A. G., Tang, Y., Mu, H., Wang, S., Geacintov, N. E., Zhang, Y. & Broyde, S., Jul 15 2013, In : Chemical research in toxicology. 26, 7, p. 1115-1125 11 p.

    Research output: Contribution to journalArticle

    Generation of guanine-thymine cross-links in human cells by one-electron oxidation mechanisms

    Madugundu, G. S., Wagner, J. R., Cadet, J., Kropachev, K., Yun, B. H., Geacintov, N. E. & Shafirovich, V., Jul 15 2013, In : Chemical research in toxicology. 26, 7, p. 1031-1033 3 p.

    Research output: Contribution to journalArticle

    Role of structural and energetic factors in regulating repair of a bulky DNA lesion with different opposite partner bases

    Mu, H., Kropachev, K., Chen, Y., Zhang, H., Cai, Y., Geacintov, N. E. & Broyde, S., Aug 20 2013, In : Biochemistry. 52, 33, p. 5517-5521 5 p.

    Research output: Contribution to journalArticle

    Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions

    Khutsishvili, I., Zhang, N., Marky, L. A., Crean, C., Patel, D. J., Geacintov, N. E. & Shafirovich, V., Feb 26 2013, In : Biochemistry. 52, 8, p. 1354-1363 10 p.

    Research output: Contribution to journalArticle

    2012

    DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

    Diamant, N., Hendel, A., Vered, I., Carell, T., Reißner, T., De Wind, N., Geacinov, N. & Livneh, Z., Jan 1 2012, In : Nucleic acids research. 40, 1, p. 170-180 11 p.

    Research output: Contribution to journalArticle

    Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair

    Skosareva, L. V., Lebedeva, N. A., Rechkunova, N. I., Kolbanovskiy, A., Geacintov, N. E. & Lavrik, O. I., Apr 1 2012, In : DNA Repair. 11, 4, p. 367-373 7 p.

    Research output: Contribution to journalArticle

    Lifetimes and reaction pathways of guanine radical cations and neutral guanine radicals in an oligonucleotide in aqueous solutions

    Rokhlenko, Y., Geacintov, N. E. & Shafirovich, V., Mar 14 2012, In : Journal of the American Chemical Society. 134, 10, p. 4955-4962 8 p.

    Research output: Contribution to journalArticle

    Nuclear magnetic resonance solution structure of an N2-guanine DNA adduct derived from the potent tumorigen dibenzo[a, l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing

    Tang, Y., Liu, Z., Ding, S., Lin, C. H., Cai, Y., Rodriguez, F. A., Sayer, J. M., Jerina, D. M., Amin, S., Broyde, S. & Geacintov, N. E., Dec 4 2012, In : Biochemistry. 51, 48, p. 9751-9762 12 p.

    Research output: Contribution to journalArticle

    Nucleotide excision repair of 2-acetylaminofluorene-and 2-aminofluorene-(C8)-guanine adducts: Molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

    Mu, H., Kropachev, K., Wang, L., Zhang, L., Kolbanovskiy, A., Kolbanovskiy, M., Geacintov, N. E. & Broyde, S., Oct 1 2012, In : Nucleic acids research. 40, 19, p. 9675-9690 16 p.

    Research output: Contribution to journalArticle

    Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion

    Lior-Hoffmann, L., Wang, L., Wang, S., Geacintov, N. E., Broyde, S. & Zhang, Y., Oct 1 2012, In : Nucleic acids research. 40, 18, p. 9193-9205 13 p.

    Research output: Contribution to journalArticle

    Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods

    Minero, A. S., Lukashevich, O. V., Cherepanova, N. A., Kolbanovskiy, A., Geacintov, N. E. & Gromova, E. S., Oct 1 2012, In : FEBS Journal. 279, 20, p. 3965-3980 16 p.

    Research output: Contribution to journalArticle