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Paramjit Arora

Professor of Chemistry

    1993 …2019
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    Research Output 1993 2019

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    Article
    2019

    Rational Design of an Organocatalyst for Peptide Bond Formation

    Handoko, Satishkumar, S., Panigrahi, N. R. & Arora, P. S., Oct 9 2019, In : Journal of the American Chemical Society. 141, 40, p. 15977-15985 9 p.

    Research output: Contribution to journalArticle

    Amides
    Peptides
    Catalysts
    Amino Acids
    Peptide Biosynthesis
    2018

    Hydrogen Bond Surrogate Stabilization of β-Hairpins

    Sawyer, N. & Arora, P., Aug 17 2018, In : ACS Chemical Biology. 13, 8, p. 2027-2032 6 p.

    Research output: Contribution to journalArticle

    Hydrogen
    Hydrogen bonds
    Stabilization
    Proteins
    Peptides

    Synthetic Control of Tertiary Helical Structures in Short Peptides

    Wuo, M. G., Hong, S. H., Singh, A. & Arora, P., Nov 28 2018, In : Journal of the American Chemical Society. 140, 47, p. 16284-16290 7 p.

    Research output: Contribution to journalArticle

    Dimers
    Peptides
    Epitopes
    Salts
    Covalent bonds
    2017

    Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel

    Ghosal, K., Colby, J. M., Das, D., Joy, S. T., Arora, P. & Krantz, B. A., Mar 24 2017, In : Journal of Molecular Biology. 429, 6, p. 900-910 11 p.

    Research output: Contribution to journalArticle

    Phenylalanine
    Peptides
    Hydrogen
    anthrax toxin
    Antigens

    Iterative design of a biomimetic catalyst for amino acid thioester condensation

    Wu, H., Handoko, Raj, M. & Arora, P., 2017, In : Organic Letters. 19, 19, p. 5122-5125 4 p.

    Research output: Contribution to journalArticle

    Biomimetics
    biomimetics
    peptides
    amino acids
    Condensation

    Protein Domain Mimics as Modulators of Protein-Protein Interactions

    Sawyer, N., Watkins, A. M. & Arora, P., Jun 20 2017, In : Accounts of Chemical Research. 50, 6, p. 1313-1322 10 p.

    Research output: Contribution to journalArticle

    Modulators
    Hydrogen bonds
    Triazoles
    Proteins
    Dimers

    Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers

    Watkins, A. M., Craven, T. W., Renfrew, P. D., Arora, P. & Bonneau, R., 2017, (Accepted/In press) In : Structure.

    Research output: Contribution to journalArticle

    Amino Acids
    Physical Chemistry
    Peptidomimetics
    Nylons
    Computer Simulation

    Targeting Unoccupied Surfaces on Protein-Protein Interfaces

    Rooklin, D., Modell, A. E., Li, H., Berdan, V., Arora, P. & Zhang, Y., Nov 8 2017, In : Journal of the American Chemical Society. 139, 44, p. 15560-15563 4 p.

    Research output: Contribution to journalArticle

    Membrane Proteins
    Peptidomimetics
    Proteins
    Amino Acid Motifs
    Fluorescence Polarization
    2016

    An optimal hydrogen-bond surrogate for α-helices

    Joy, S. T. & Arora, P., Apr 28 2016, In : Chemical Communications. 52, 33, p. 5738-5741 4 p.

    Research output: Contribution to journalArticle

    Peptides
    Hydrogen bonds
    Covalent bonds
    Alkenes
    Olefins

    Side-Chain Conformational Preferences Govern Protein-Protein Interactions

    Watkins, A. M., Bonneau, R. & Arora, P., Aug 24 2016, In : Journal of the American Chemical Society. 138, 33, p. 10386-10389 4 p.

    Research output: Contribution to journalArticle

    Proteins
    Conformations
    Peptidomimetics
    Secondary Protein Structure
    Protein Folding

    Systematic Targeting of Protein-Protein Interactions

    Modell, A. E., Blosser, S. L. & Arora, P., Feb 23 2016, (Accepted/In press) In : Trends in Pharmacological Sciences.

    Research output: Contribution to journalArticle

    Protein Transport
    Proteins
    Modulators
    Workflow
    Secondary Protein Structure
    2015

    Aldehyde capture ligation for synthesis of native peptide bonds

    Raj, M., Wu, H., Blosser, S. L., Vittoria, M. A. & Arora, P., Jun 3 2015, In : Journal of the American Chemical Society. 137, 21, p. 6932-6940 9 p.

    Research output: Contribution to journalArticle

    Aldehydes
    Amides
    Peptides
    Ligation
    Amines

    AlphaSpace: Fragment-Centric Topographical Mapping to Target Protein-Protein Interaction Interfaces

    Rooklin, D., Wang, C., Katigbak, J., Arora, P. & Zhang, Y., Aug 24 2015, In : Journal of Chemical Information and Modeling. 55, 8, p. 1585-1599 15 p.

    Research output: Contribution to journalArticle

    Proteins
    interaction
    drug
    Membrane Proteins
    Atoms

    An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics

    Wuo, M. G., Mahon, A. B. & Arora, P., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11618-11621 4 p.

    Research output: Contribution to journalArticle

    Protein Multimerization
    Proteins
    Biological Phenomena
    Disulfides
    Covalent bonds

    Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs

    Watkins, A. M., Wuo, M. G. & Arora, P., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11622-11630 9 p.

    Research output: Contribution to journalArticle

    Proteins
    Secondary Protein Structure
    Modulators
    Conformations
    Databases

    Structure-based inhibition of protein-protein interactions

    Watkins, A. M. & Arora, P., Apr 13 2015, In : European Journal of Medicinal Chemistry. 94, p. 480-488 9 p.

    Research output: Contribution to journalArticle

    Proteins
    Peptidomimetics
    Secondary Protein Structure
    Workflow
    Drug Design
    2014

    Amyloid fibrils nucleated and organized by DNA origami constructions

    Udomprasert, A., Bongiovanni, M. N., Sha, R., Sherman, W. B., Wang, T., Arora, P., Canary, J., Gras, S. L. & Seeman, N., 2014, In : Nature Nanotechnology. 9, 7, p. 537-541 5 p.

    Research output: Contribution to journalArticle

    Amyloid
    DNA
    deoxyribonucleic acid
    Nanotubes
    nanotubes

    Anatomy of β-strands at protein-protein interfaces

    Watkins, A. M. & Arora, P., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1747-1754 8 p.

    Research output: Contribution to journalArticle

    Anatomy
    Proteins
    Molecular recognition
    Databases
    Guidelines

    Effects of side chains in helix nucleation differ from helix propagation

    Miller, S. E., Watkins, A. M., Kallenbach, N. R. & Arora, P., May 6 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 18, p. 6636-6641 6 p.

    Research output: Contribution to journalArticle

    Amino Acids
    Peptides
    Proteins

    In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

    Lao, B. B., Grishagin, I., Mesallati, H., Brewer, T. F., Olenyuk, B. Z. & Arora, P., May 27 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 21, p. 7531-7536 6 p.

    Research output: Contribution to journalArticle

    Proteins
    Hypoxia-Inducible Factor 1
    Tumor Burden
    Energy Metabolism
    Hypoxia

    Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions

    Lao, B. B., Drew, K., Guarracino, D. A., Brewer, T. F., Heindel, D. W., Bonneau, R. & Arora, P. S., Jun 4 2014, In : Journal of the American Chemical Society. 136, 22, p. 7877-7888 12 p.

    Research output: Contribution to journalArticle

    Proteins
    Libraries
    Peptidomimetics
    Binding energy
    Scaffolds

    Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions

    Miller, S. E., Thomson, P. F. & Arora, P., 2014, In : Current protocols in chemical biology. 6, 2, p. 101-116 16 p.

    Research output: Contribution to journalArticle

    Hydrogen
    Solid-Phase Synthesis Techniques
    Proteins
    Peptides
    Secondary Protein Structure

    Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

    Xie, X., Piao, L., Bullock, B. N., Smith, A., Su, T., Zhang, M., Teknos, T. N., Arora, P. & Pan, Q., Feb 20 2014, In : Oncogene. 33, 8, p. 1037-1046 10 p.

    Research output: Contribution to journalArticle

    Carcinoma, squamous cell of head and neck
    Acetylation
    Cisplatin
    Neoplasms
    Cell Proliferation
    2013

    Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design

    Drew, K., Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Chou, F. C., Lyskov, S., Bullock, B. N., Watkins, A., Labonte, J. W., Pacella, M., Kilambi, K. P., Leaver-Fay, A., Kuhlman, B., Gray, J. J., Bradley, P., Kirshenbaum, K., Arora, P. S., Das, R. & Bonneau, R., Jul 15 2013, In : PLoS One. 8, 7, e67051.

    Research output: Contribution to journalArticle

    Peptidomimetics
    Oligomers
    protein-protein interactions
    Proteins
    Peptides

    An Orthosteric Inhibitor of the RAS-SOS Interaction

    Nickerson, S., Joy, S. T., Arora, P. & Bar-Sagi, D., 2013, In : Enzymes. 34, p. 25-39 15 p.

    Research output: Contribution to journalArticle

    Sarcoma
    Rats
    Nucleotides
    Chemical activation
    Peptides

    HippDB: A database of readily targeted helical protein-protein interactions

    Bergey, C. M., Watkins, A. M. & Arora, P., Nov 1 2013, In : Bioinformatics. 29, 21, p. 2806-2807 2 p.

    Research output: Contribution to journalArticle

    Protein-protein Interaction
    Databases
    Helix
    Proteins
    Websites

    Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions

    Raj, M., Bullock, B. N. & Arora, P., Jul 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4051-4057 7 p.

    Research output: Contribution to journalArticle

    Protein Transport
    Fruits
    Fruit
    Proteins
    Ligands

    Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

    Kushal, S., Lao, B. B., Henchey, L. K., Dubey, R., Mesallati, H., Traaseth, N., Olenyuk, B. Z. & Arora, P., Sep 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 39, p. 15602-15607 6 p.

    Research output: Contribution to journalArticle

    Transcription Factors
    p300-CBP Transcription Factors
    Hypoxia-Inducible Factor 1
    Neoplasm Genes
    Gene Expression Profiling
    2012

    Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells

    Jespersen, C., Soragni, E., James Chou, C., Arora, P., Dervan, P. B. & Gottesfeld, J. M., Jun 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 12, p. 4068-4071 4 p.

    Research output: Contribution to journalArticle

    Chlorambucil
    Nylons
    Pancreatic Neoplasms
    Histones
    Chromatin

    Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

    Mahon, A. B. & Arora, P., Feb 1 2012, In : Chemical Communications. 48, 10, p. 1416-1418 3 p.

    Research output: Contribution to journalArticle

    Sulfides
    Hydrogen bonds
    Proteins
    Conformations

    End-capped α-helices as modulators of protein function

    Mahon, A. B. & Arora, P., Mar 2012, In : Drug Discovery Today: Technologies. 9, 1

    Research output: Contribution to journalArticle

    Proteins
    Secondary Protein Structure
    Nucleic Acids
    Hypoxia-Inducible Factor 1
    Transcription
    Hydrogen bonds

    Nucleation effects in peptide foldamers

    Patgiri, A., Joy, S. T. & Arora, P., Jul 18 2012, In : Journal of the American Chemical Society. 134, 28, p. 11495-11502 8 p.

    Research output: Contribution to journalArticle

    Oligomers
    Peptides
    Conformations
    Amino acids
    Nucleation

    Reversible redox reconfiguration of secondary structures in a designed peptide

    Wang, X., Bergenfeld, I., Arora, P. & Canary, J., Nov 26 2012, In : Angewandte Chemie - International Edition. 51, 48, p. 12099-12101 3 p.

    Research output: Contribution to journalArticle

    Peptides
    Protein folding
    Conformations
    Monomers
    Proteins

    Reversible α-helix formation controlled by a hydrogen bond surrogate

    Miller, S. E., Kallenbach, N. R. & Arora, P., Jun 10 2012, In : Tetrahedron. 68, 23, p. 4434-4437 4 p.

    Research output: Contribution to journalArticle

    Disulfides
    Hydrogen
    Hydrogen bonds
    Structural analysis
    Oxidation-Reduction
    2011

    An orthosteric inhibitor of the Ras-Sos interaction

    Patgiri, A., Yadav, K. K., Arora, P. & Bar-Sagi, D., Sep 2011, In : Nature Chemical Biology. 7, 9, p. 585-587 3 p.

    Research output: Contribution to journalArticle

    Artificial Cells
    Guanine Nucleotide Exchange Factors
    Receptor Protein-Tyrosine Kinases
    Membrane Proteins
    Proteins

    Assessing helical protein interfaces for inhibitor design

    Bullock, B. N., Jochim, A. L. & Arora, P., Sep 14 2011, In : Journal of the American Chemical Society. 133, 36, p. 14220-14223 4 p.

    Research output: Contribution to journalArticle

    Proteins
    Databases

    Protein-protein interactions in transcription: A fertile ground for helix mimetics

    Guarracino, D. A., Bullock, B. N. & Arora, P., Jan 2011, In : Biopolymers - Peptide Science Section. 95, 1, p. 1-7 7 p.

    Research output: Contribution to journalArticle

    Transcription
    Proteins
    Ligands
    Drug Discovery
    Genomics
    2010

    High specificity in protein recognition by hydrogen-bond-surrogate α-helices: Selective inhibition of the p53/MDM2 complex

    Henchey, L. K., Porter, J. R., Ghosh, I. & Arora, P., Oct 18 2010, In : ChemBioChem. 11, 15, p. 2104-2107 4 p.

    Research output: Contribution to journalArticle

    Proto-Oncogene Proteins c-mdm2
    Peptidomimetics
    Tumor Suppressor Protein p53
    Molecular recognition
    X ray crystallography

    Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate α-helix

    Henchey, L. K., Kushal, S., Dubey, R., Chapman, R. N., Olenyuk, B. Z. & Arora, P., 2010, In : Journal of the American Chemical Society. 132, 3, p. 941-943 3 p.

    Research output: Contribution to journalArticle

    p300-CBP Transcription Factors
    Hypoxia-Inducible Factor 1
    Transcription
    Cell culture
    Histidine

    Oligooxopiperazines as nonpeptidic α-helix mimetics

    Tošovská, P. & Arora, P., Apr 2 2010, In : Organic Letters. 12, 7, p. 1588-1591 4 p.

    Research output: Contribution to journalArticle

    Circular dichroism spectroscopy
    Molecular modeling
    Circular Dichroism
    Dimers
    helices

    Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

    Porter, J. R., Helmers, M. R., Wang, P., Furman, J. L., Joy, S. T., Arora, P. & Ghosh, I., Nov 14 2010, In : Chemical Communications. 46, 42, p. 8020-8022 3 p.

    Research output: Contribution to journalArticle

    Proteins
    Molecules

    Solid phase synthesis of hydrogen bond surrogate derived α-helices: Resolving the case of a difficult amide coupling

    Patgiri, A., Witten, M. R. & Arora, P., 2010, In : Organic and Biomolecular Chemistry. 8, 8, p. 1773-1776 4 p.

    Research output: Contribution to journalArticle

    Solid-Phase Synthesis Techniques
    Amides
    helices
    amides
    solid phases

    Solid-phase synthesis of short Î ±-helices stabilized by the hydrogen bond surrogate approach

    Patgiri, A., Menzenski, M. Z., Mahon, A. B. & Arora, P., Oct 2010, In : Nature Protocols. 5, 11, p. 1857-1865 9 p.

    Research output: Contribution to journalArticle

    Solid-Phase Synthesis Techniques
    Hydrogen
    Hydrogen bonds
    Carbon
    Proteins

    Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

    Jochim, A. L. & Arora, P., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 919-923 5 p.

    Research output: Contribution to journalArticle

    Proteins
    Molecules
    Databases
    Ligands
    2009

    Assessment of helical interfaces in protein-protein interactions

    Jochim, A. L. & Arora, P., 2009, In : Molecular BioSystems. 5, 9, p. 924-926 3 p.

    Research output: Contribution to journalArticle

    Proteins

    Chemical biology: A Notch above other inhibitors

    Arora, P. & Ansari, A. Z., Nov 12 2009, In : Nature. 462, 7270, p. 171-173 3 p.

    Research output: Contribution to journalArticle

    Drug Discovery
    Peptides

    Dynamical binding of hydrogen-bond surrogate derived bak helices to antiapoptotic protein Bcl-xL

    Bao, J., Dong, X. Y., Zhang, J. & Arora, P., Mar 19 2009, In : Journal of Physical Chemistry B. 113, 11, p. 3565-3571 7 p.

    Research output: Contribution to journalArticle

    helices
    Hydrogen bonds
    hydrogen bonds
    proteins
    Proteins

    Evaluation of triazolamers as active site inhibitors of HIV-1 protease

    Jochim, A. L., Miller, S. E., Angelo, N. G. & Arora, P., Nov 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 21, p. 6023-6026 4 p.

    Research output: Contribution to journalArticle

    Peptidomimetics
    Triazoles
    Protease Inhibitors
    Conformations
    Catalytic Domain

    Making Strides in Peptide-Based Therapeutics

    Guarracino, D. A. & Arora, P., Sep 25 2009, In : Chemistry and Biology. 16, 9, p. 919-920 2 p.

    Research output: Contribution to journalArticle

    HIV
    Peptides
    Therapeutics