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Paramjit Arora

Professor of Chemistry

    1993 …2020

    Research output per year

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    Research Output

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    Article
    2020

    Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics

    Sadek, J., Wuo, M. G., Rooklin, D., Hauenstein, A., Hong, S. H., Gautam, A., Wu, H., Zhang, Y., Cesarman, E. & Arora, P. S., Dec 1 2020, In : Nature communications. 11, 1, 1786.

    Research output: Contribution to journalArticle

    Open Access
    2019

    Rational Design of an Organocatalyst for Peptide Bond Formation

    Handoko, Satishkumar, S., Panigrahi, N. R. & Arora, P. S., Oct 9 2019, In : Journal of the American Chemical Society. 141, 40, p. 15977-15985 9 p.

    Research output: Contribution to journalArticle

    2018

    Hydrogen Bond Surrogate Stabilization of β-Hairpins

    Sawyer, N. & Arora, P. S., Aug 17 2018, In : ACS Chemical Biology. 13, 8, p. 2027-2032 6 p.

    Research output: Contribution to journalArticle

    Synthetic Control of Tertiary Helical Structures in Short Peptides

    Wuo, M. G., Hong, S. H., Singh, A. & Arora, P. S., Nov 28 2018, In : Journal of the American Chemical Society. 140, 47, p. 16284-16290 7 p.

    Research output: Contribution to journalArticle

    2017

    Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel

    Ghosal, K., Colby, J. M., Das, D., Joy, S. T., Arora, P. S. & Krantz, B. A., Mar 24 2017, In : Journal of Molecular Biology. 429, 6, p. 900-910 11 p.

    Research output: Contribution to journalArticle

    Iterative design of a biomimetic catalyst for amino acid thioester condensation

    Wu, H., Handoko, Raj, M. & Arora, P. S., Jan 1 2017, In : Organic Letters. 19, 19, p. 5122-5125 4 p.

    Research output: Contribution to journalArticle

    Protein Domain Mimics as Modulators of Protein-Protein Interactions

    Sawyer, N., Watkins, A. M. & Arora, P. S., Jun 20 2017, In : Accounts of Chemical Research. 50, 6, p. 1313-1322 10 p.

    Research output: Contribution to journalArticle

    Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers

    Watkins, A. M., Craven, T. W., Renfrew, P. D., Arora, P. S. & Bonneau, R., Nov 7 2017, In : Structure. 25, 11, p. 1771-1780.e3

    Research output: Contribution to journalArticle

    Targeting Unoccupied Surfaces on Protein-Protein Interfaces

    Rooklin, D., Modell, A. E., Li, H., Berdan, V., Arora, P. S. & Zhang, Y., Nov 8 2017, In : Journal of the American Chemical Society. 139, 44, p. 15560-15563 4 p.

    Research output: Contribution to journalArticle

    2016

    An optimal hydrogen-bond surrogate for α-helices

    Joy, S. T. & Arora, P. S., Apr 28 2016, In : Chemical Communications. 52, 33, p. 5738-5741 4 p.

    Research output: Contribution to journalArticle

    Side-Chain Conformational Preferences Govern Protein-Protein Interactions

    Watkins, A. M., Bonneau, R. & Arora, P. S., Aug 24 2016, In : Journal of the American Chemical Society. 138, 33, p. 10386-10389 4 p.

    Research output: Contribution to journalArticle

    2015

    Aldehyde capture ligation for synthesis of native peptide bonds

    Raj, M., Wu, H., Blosser, S. L., Vittoria, M. A. & Arora, P. S., Jun 3 2015, In : Journal of the American Chemical Society. 137, 21, p. 6932-6940 9 p.

    Research output: Contribution to journalArticle

    AlphaSpace: Fragment-Centric Topographical Mapping to Target Protein-Protein Interaction Interfaces

    Rooklin, D., Wang, C., Katigbak, J., Arora, P. S. & Zhang, Y., Aug 24 2015, In : Journal of Chemical Information and Modeling. 55, 8, p. 1585-1599 15 p.

    Research output: Contribution to journalArticle

    An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics

    Wuo, M. G., Mahon, A. B. & Arora, P. S., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11618-11621 4 p.

    Research output: Contribution to journalArticle

    Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs

    Watkins, A. M., Wuo, M. G. & Arora, P. S., Sep 16 2015, In : Journal of the American Chemical Society. 137, 36, p. 11622-11630 9 p.

    Research output: Contribution to journalArticle

    Structure-based inhibition of protein-protein interactions

    Watkins, A. M. & Arora, P. S., Apr 13 2015, In : European journal of medicinal chemistry. 94, p. 480-488 9 p.

    Research output: Contribution to journalArticle

    2014

    Amyloid fibrils nucleated and organized by DNA origami constructions

    Udomprasert, A., Bongiovanni, M. N., Sha, R., Sherman, W. B., Wang, T., Arora, P. S., Canary, J. W., Gras, S. L. & Seeman, N. C., Jul 2014, In : Nature Nanotechnology. 9, 7, p. 537-541 5 p.

    Research output: Contribution to journalArticle

    Anatomy of β-strands at protein-protein interfaces

    Watkins, A. M. & Arora, P. S., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1747-1754 8 p.

    Research output: Contribution to journalArticle

    Effects of side chains in helix nucleation differ from helix propagation

    Miller, S. E., Watkins, A. M., Kallenbach, N. R. & Arora, P. S., May 6 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 18, p. 6636-6641 6 p.

    Research output: Contribution to journalArticle

    In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

    Lao, B. B., Grishagin, I., Mesallati, H., Brewer, T. F., Olenyuk, B. Z. & Arora, P. S., May 27 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 21, p. 7531-7536 6 p.

    Research output: Contribution to journalArticle

    Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions

    Lao, B. B., Drew, K., Guarracino, D. A., Brewer, T. F., Heindel, D. W., Bonneau, R. & Arora, P. S., Jun 4 2014, In : Journal of the American Chemical Society. 136, 22, p. 7877-7888 12 p.

    Research output: Contribution to journalArticle

    Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions

    Miller, S. E., Thomson, P. F. & Arora, P. S., Jan 1 2014, In : Current protocols in chemical biology. 6, 2, p. 101-116 16 p.

    Research output: Contribution to journalArticle

    Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

    Xie, X., Piao, L., Bullock, B. N., Smith, A., Su, T., Zhang, M., Teknos, T. N., Arora, P. S. & Pan, Q., Feb 20 2014, In : Oncogene. 33, 8, p. 1037-1046 10 p.

    Research output: Contribution to journalArticle

    2013

    Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design

    Drew, K., Renfrew, P. D., Craven, T. W., Butterfoss, G. L., Chou, F. C., Lyskov, S., Bullock, B. N., Watkins, A., Labonte, J. W., Pacella, M., Kilambi, K. P., Leaver-Fay, A., Kuhlman, B., Gray, J. J., Bradley, P., Kirshenbaum, K., Arora, P. S., Das, R. & Bonneau, R., Jul 15 2013, In : PloS one. 8, 7, e67051.

    Research output: Contribution to journalArticle

    HippDB: A database of readily targeted helical protein-protein interactions

    Bergey, C. M., Watkins, A. M. & Arora, P. S., Nov 1 2013, In : Bioinformatics. 29, 21, p. 2806-2807 2 p.

    Research output: Contribution to journalArticle

    Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions

    Raj, M., Bullock, B. N. & Arora, P. S., Jul 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4051-4057 7 p.

    Research output: Contribution to journalArticle

    Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

    Kushal, S., Lao, B. B., Henchey, L. K., Dubey, R., Mesallati, H., Traaseth, N. J., Olenyuk, B. Z. & Arora, P. S., Sep 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 39, p. 15602-15607 6 p.

    Research output: Contribution to journalArticle

    2012

    Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells

    Jespersen, C., Soragni, E., James Chou, C., Arora, P. S., Dervan, P. B. & Gottesfeld, J. M., Jun 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 12, p. 4068-4071 4 p.

    Research output: Contribution to journalArticle

    Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

    Mahon, A. B. & Arora, P. S., Jan 11 2012, In : Chemical Communications. 48, 10, p. 1416-1418 3 p.

    Research output: Contribution to journalArticle

    Nucleation effects in peptide foldamers

    Patgiri, A., Joy, S. T. & Arora, P. S., Jul 18 2012, In : Journal of the American Chemical Society. 134, 28, p. 11495-11502 8 p.

    Research output: Contribution to journalArticle

    Reversible redox reconfiguration of secondary structures in a designed peptide

    Wang, X., Bergenfeld, I., Arora, P. S. & Canary, J. W., Nov 26 2012, In : Angewandte Chemie - International Edition. 51, 48, p. 12099-12101 3 p.

    Research output: Contribution to journalArticle

    Reversible α-helix formation controlled by a hydrogen bond surrogate

    Miller, S. E., Kallenbach, N. R. & Arora, P. S., Jun 10 2012, In : Tetrahedron. 68, 23, p. 4434-4437 4 p.

    Research output: Contribution to journalArticle

    2011

    An orthosteric inhibitor of the Ras-Sos interaction

    Patgiri, A., Yadav, K. K., Arora, P. S. & Bar-Sagi, D., Sep 2011, In : Nature Chemical Biology. 7, 9, p. 585-587 3 p.

    Research output: Contribution to journalArticle

    Assessing helical protein interfaces for inhibitor design

    Bullock, B. N., Jochim, A. L. & Arora, P. S., Sep 14 2011, In : Journal of the American Chemical Society. 133, 36, p. 14220-14223 4 p.

    Research output: Contribution to journalArticle

    Protein-protein interactions in transcription: A fertile ground for helix mimetics

    Guarracino, D. A., Bullock, B. N. & Arora, P. S., Jan 1 2011, In : Biopolymers. 95, 1, p. 1-7 7 p.

    Research output: Contribution to journalArticle

    2010

    High specificity in protein recognition by hydrogen-bond-surrogate α-helices: Selective inhibition of the p53/MDM2 complex

    Henchey, L. K., Porter, J. R., Ghosh, I. & Arora, P. S., Oct 18 2010, In : ChemBioChem. 11, 15, p. 2104-2107 4 p.

    Research output: Contribution to journalArticle

    Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate α-helix

    Henchey, L. K., Kushal, S., Dubey, R., Chapman, R. N., Olenyuk, B. Z. & Arora, P. S., Jan 1 2010, In : Journal of the American Chemical Society. 132, 3, p. 941-943 3 p.

    Research output: Contribution to journalArticle

    Oligooxopiperazines as nonpeptidic α-helix mimetics

    Tošovská, P. & Arora, P. S., Apr 2 2010, In : Organic Letters. 12, 7, p. 1588-1591 4 p.

    Research output: Contribution to journalArticle

    Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

    Porter, J. R., Helmers, M. R., Wang, P., Furman, J. L., Joy, S. T., Arora, P. S. & Ghosh, I., Nov 14 2010, In : Chemical Communications. 46, 42, p. 8020-8022 3 p.

    Research output: Contribution to journalArticle

    Solid phase synthesis of hydrogen bond surrogate derived α-helices: Resolving the case of a difficult amide coupling

    Patgiri, A., Witten, M. R. & Arora, P. S., Apr 7 2010, In : Organic and Biomolecular Chemistry. 8, 8, p. 1773-1776 4 p.

    Research output: Contribution to journalArticle

    Solid-phase synthesis of short Î ±-helices stabilized by the hydrogen bond surrogate approach

    Patgiri, A., Menzenski, M. Z., Mahon, A. B. & Arora, P. S., Oct 1 2010, In : Nature Protocols. 5, 11, p. 1857-1865 9 p.

    Research output: Contribution to journalArticle

    Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

    Jochim, A. L. & Arora, P. S., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 919-923 5 p.

    Research output: Contribution to journalArticle

    2009

    Assessment of helical interfaces in protein-protein interactions

    Jochim, A. L. & Arora, P. S., Aug 24 2009, In : Molecular BioSystems. 5, 9, p. 924-926 3 p.

    Research output: Contribution to journalArticle

    Dynamical binding of hydrogen-bond surrogate derived bak helices to antiapoptotic protein Bcl-xL

    Bao, J., Dong, X. Y., Zhang, J. Z. H. & Arora, P. S., Mar 19 2009, In : Journal of Physical Chemistry B. 113, 11, p. 3565-3571 7 p.

    Research output: Contribution to journalArticle

    Evaluation of triazolamers as active site inhibitors of HIV-1 protease

    Jochim, A. L., Miller, S. E., Angelo, N. G. & Arora, P. S., Nov 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 21, p. 6023-6026 4 p.

    Research output: Contribution to journalArticle

    2008

    A hydrogen bond surrogate approach for stabilization of short peptide sequences in α-helical conformation

    Patgiri, A., Jochim, A. L. & Arora, P. S., Oct 1 2008, In : Accounts of Chemical Research. 41, 10, p. 1289-1300 12 p.

    Research output: Contribution to journalArticle

    Atomic structure of a short α-helix stabilized by a main chain hydrogen-bond surrogate

    Liu, J., Wang, D., Zheng, Q., Lu, M. & Arora, P. S., Apr 2 2008, In : Journal of the American Chemical Society. 130, 13, p. 4334-4337 4 p.

    Research output: Contribution to journalArticle

    Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based α helices

    Wang, D., Lu, M. & Arora, P. S., Feb 22 2008, In : Angewandte Chemie - International Edition. 47, 10, p. 1879-1882 4 p.

    Research output: Contribution to journalArticle

    Structure and function in hydrogen-bond surrogate based α-helices

    Patgiri, A., Jochim, A. L. & Arora, P., 2008, In : Accounts of Chemical Research. 41, p. 1289-1300 (Invited article for a special issue on peptidomimetics).

    Research output: Contribution to journalArticle

    Trapping a folding intermediate of the α-helix: Stabilization of the π-helix

    Chapman, R., Kulp, J. L., Patgiri, A., Kallenbach, N. R., Bracken, C. & Arora, P. S., Apr 8 2008, In : Biochemistry. 47, 14, p. 4189-4195 7 p.

    Research output: Contribution to journalArticle