Shoshana Yakar

Associate Professor, Basic Science and Craniofacial Biology

19942018
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Insulin-Like Growth Factor I Medicine & Life Sciences
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IGF Type 1 Receptor Medicine & Life Sciences
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Growth Medicine & Life Sciences
Type 2 Diabetes Mellitus Medicine & Life Sciences

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Research Output 1994 2018

40 years of IGF1: Insulin-like growth factors: Actions on the skeleton

Yakar, S., Werner, H. & Rosen, C. J., Jul 1 2018, In : Journal of Molecular Endocrinology. 61, 1, p. T115-T137

Research output: Contribution to journalReview article

Somatomedins
Skeleton
Growth Hormone
Research Personnel
Osteocytes

Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action

Nagaraj, K., Lapkina-Gendler, L., Sarfstein, R., Gurwitz, D., Pasmanik-Chor, M., Laron, Z., Yakar, S. & Werner, H., Jan 30 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 5, p. 1045-1050 6 p.

Research output: Contribution to journalArticle

Thioredoxins
Somatomedins
Laron Syndrome
Proteins
Neoplasms

Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency

Rayes, R. F., Milette, S., Fernandez, M. C., Ham, B., Wang, N., Bourdeau, F., Perrino, S., Yakar, S. & Brodt, P., Jan 1 2018, In : Oncotarget. 9, 21, p. 15691-15704 14 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Colon
Neutrophils
Neoplasm Metastasis
Carcinoma

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice

Liu, Z., Solesio, M. E., Schaffler, M. B., Frikha-Benayed, D., Rosen, C. J., Werner, H., Kopchick, J. J., Pavlov, E., Abramov, A. Y. & Yakar, S., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Somatotropin Receptors
Osteocytes
Mitochondrial Membrane Potential
Reactive Oxygen Species
Cortical Bone

Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass

Liu, Z., Han, T., Werner, H., Rosen, C. J., Schaffler, M. B. & Yakar, S., Jan 1 2018, In : Journal of Bone and Mineral Research. 33, 1, p. 123-136 14 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Liver
Serum
Transgenes
Liver Diseases