Photo of Weiqiang Chen

Weiqiang Chen

Assistant Professor

    20072020

    Research output per year

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    Research Output

    2020

    AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells

    Deliorman, M., Janahi, F. K., Sukumar, P., Alnemari, R., Fadl, S., Chen, W. & Qasaimeh, M., Mar 23 2020, In : Microsystems and Nanoengineering. 20.

    Research output: Contribution to journalArticle

    Open Access

    Air-plug enabled localization of single cell entrapment in an array of rectangular microwells

    Sukumar, P., Alnemari, R., Chen, W. & Qasaimeh, M. A., Jan 1 2020, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, p. 671-672 2 p. (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

    Witkowski, M. T., Dolgalev, I., Evensen, N. A., Ma, C., Chambers, T., Roberts, K. G., Sreeram, S., Dai, Y., Tikhonova, A. N., Lasry, A., Qu, C., Pei, D., Cheng, C., Robbins, G. A., Pierro, J., Selvaraj, S., Mezzano, V., Daves, M., Lupo, P. J., Scheurer, M. E. & 7 others, Loomis, C. A., Mullighan, C. G., Chen, W., Rabin, K. R., Tsirigos, A., Carroll, W. L. & Aifantis, I., Jun 8 2020, In : Cancer Cell. 37, 6, p. 867-882.e12

    Research output: Contribution to journalArticle

    2019

    Airplug‐Mediated Isolation and Centralization of Single T Cells in Rectangular Microwells for Biosensing

    Sukumar, P., Deliorman, M., Brimmo, A. T., Alnemari, R., Elsori, D., Chen, W. & Qasaimeh, M., Oct 15 2019, In : Wiley Online Library.

    Research output: Contribution to journalArticle

    Open Access

    A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation

    Wang, H., Morales, R. T. T., Cui, X., Huang, J., Qian, W., Tong, J. & Chen, W., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1801234.

    Research output: Contribution to journalArticle

    Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-Like Cells

    Chen, W., Allen, S. G., Qian, W., Peng, Z., Han, S., Li, X., Sun, Y., Fournier, C., Bao, L., Lam, R. H. W., Merajver, S. D. & Fu, J., Jan 1 2019, (Accepted/In press) In : Small. 15, 5, 1802891.

    Research output: Contribution to journalArticle

    Cellogram: On-the-Fly Traction Force Microscopy

    Lendenmann, T., Schneider, T., Dumas, J., Tarini, M., Giampietro, C., Bajpai, A., Chen, W., Gerber, J., Poulikakos, D., Ferrari, A. & Panozzo, D., Oct 9 2019, In : Nano Letters. 19, 10, p. 6742-6750 9 p.

    Research output: Contribution to journalArticle

    Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

    Witzel, I. I., Nasser, R., Garcia-Sabaté, A., Sapudom, J., Ma, C., Chen, W. & Teo, J. C. M., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1801126.

    Research output: Contribution to journalReview article

    Energy-Mediated Machinery Drives Cellular Mechanical Allostasis

    Wang, Q., Qian, W., Xu, X., Bajpai, A., Guan, K., Zhang, Z., Chen, R., Flamini, V. & Chen, W., 2019, In : Advanced Materials. 31, 35, 1900453.

    Research output: Contribution to journalArticle

    Magnet Patterned Superparamagnetic Fe3O4/Au Core–Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay

    Cai, Y., Zhu, J., He, J., Yang, W., Ma, C., Xiong, F., Li, F., Chen, W. & Chen, P., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1801478.

    Research output: Contribution to journalArticle

    Probing Single-Cell Mechanical Allostasis Using Ultrasound Tweezers

    Qian, W. & Chen, W., Oct 1 2019, In : Cellular and Molecular Bioengineering. 12, 5, p. 415-427 13 p.

    Research output: Contribution to journalArticle

    Special Issue: Bio-Interfaces for Immunoengineering

    Chen, W. & Kim, D. H., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1900098.

    Research output: Contribution to journalEditorial

    The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

    Bajpai, A., Tong, J., Qian, W., Peng, Y. & Chen, W., Nov 19 2019, In : Biophysical journal. 117, 10, p. 1795-1804 10 p.

    Research output: Contribution to journalArticle

    2018

    A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification

    Cui, X., Liu, Y., Hu, D., Qian, W., Tin, C., Sun, D., Chen, W. & Lam, R. H. W., Feb 7 2018, In : Lab on a Chip. 18, 3, p. 522-531 10 p.

    Research output: Contribution to journalArticle

    An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

    Zhu, J., He, J., Verano, M., Brimmo, A. T., Glia, A., Qasaimeh, M. A., Chen, P., Aleman, J. O. & Chen, W., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3550-3560 11 p.

    Research output: Contribution to journalArticle

    Exploring the chemoresistance mechanisms of leukemia in a biomimetic 'leukemia-on-a-chip' microsystem

    Ma, C. & Chen, W., Jan 1 2018, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Chemical and Biological Microsystems Society, p. 152-153 2 p. (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; vol. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Exploring the chemoresistance mechanisms of leukemia in a biomimetic 'leukemia-on-a-chip' microsystem

    Ma, C. & Chen, W., 2018, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Chemical and Biological Microsystems Society, p. 152-153 2 p. (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; vol. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

    Cui, X., Morales, R. T. T., Qian, W., Wang, H., Gagner, J. P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., Lam, R. H. W. & Chen, W., Apr 2018, In : Biomaterials. 161, p. 164-178 15 p.

    Research output: Contribution to journalArticle

    Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

    Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L. G., Krebsbach, P. H. & Fu, J., Feb 21 2018, In : Nanoscale. 10, 7, p. 3556-3565 10 p.

    Research output: Contribution to journalArticle

    2017

    Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

    Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A. B., Teo, J. C. M. & Chen, W., Dec 6 2017, In : ACS Applied Materials and Interfaces. 9, 48, p. 41794-41806 13 p.

    Research output: Contribution to journalArticle

    2016

    Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

    Weng, S., Shao, Y., Chen, W. & Fu, J., Sep 1 2016, In : Nature Materials. 15, 9, p. 961-967 7 p.

    Research output: Contribution to journalArticle

    Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer

    Hu, S., Liu, G., Chen, W., Li, X., Lu, W., Lam, R. H. W. & Fu, J., May 4 2016, In : Small. 12, 17, p. 2300-2311 12 p.

    Research output: Contribution to journalArticle

    Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

    Chen, W., Allen, S. G., Reka, A. K., Qian, W., Han, S., Zhao, J., Bao, L., Keshamouni, V. G., Merajver, S. D. & Fu, J., Aug 8 2016, In : BMC Cancer. 16, 1, 614.

    Research output: Contribution to journalArticle

    Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

    Liu, C., Cui, X., Ackermann, T. M., Flamini, V., Chen, W. & Castillo, A. B., Jul 2016, In : Integrative Biology (United Kingdom). 8, 7, p. 785-794 10 p.

    Research output: Contribution to journalArticle

    Surface micromachining of polydimethylsiloxane for microfluidics applications

    Hill, S., Qian, W., Chen, W. & Fu, J., Sep 1 2016, In : Biomicrofluidics. 10, 5, 054114.

    Research output: Contribution to journalArticle

    2015

    Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

    Qian, W., Zhang, Y. & Chen, W., Aug 1 2015, In : Small. 11, 32, p. 3850-3872 23 p.

    Research output: Contribution to journalReview article

    Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

    Zhang, Y., Gordon, A., Qian, W. & Chen, W., Sep 1 2015, In : Advanced Healthcare Materials. 4, 13, p. 1900-1914 15 p.

    Research output: Contribution to journalArticle

    Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

    Qian, W., Zhang, Y., Gordon, A. & Chen, W., Nov 1 2015, In : Journal of Nanotechnology in Engineering and Medicine. 5, 4, 040802.

    Research output: Contribution to journalArticle

    2014

    Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

    Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 1151-1153 3 p. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

    Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., Jul 21 2014, In : Lab on a Chip. 14, 14, p. 2565-2575 11 p.

    Research output: Contribution to journalArticle

    Emerging microengineered tools for functional analysis and phenotyping of blood cells

    Li, X., Chen, W., Li, Z., Li, L., Gu, H. & Fu, J., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 586-594 9 p.

    Research output: Contribution to journalReview article

    Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

    Shao, Y., Mann, J. M., Chen, W. & Fu, J., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 300-311 12 p.

    Research output: Contribution to journalArticle

    Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

    Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H. & Fu, J., Jun 2014, In : Nature Materials. 13, 6, p. 599-604 6 p.

    Research output: Contribution to journalArticle

    Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

    Oh, B. R., Huang, N. T., Chen, W., Seo, J. H., Chen, P., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., Mar 25 2014, In : ACS nano. 8, 3, p. 2667-2676 10 p.

    Research output: Contribution to journalArticle

    Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

    Chen, W., Shao, Y., Li, X., Zhao, G. & Fu, J., Dec 1 2014, In : Nano Today. 9, 6, p. 759-784 26 p.

    Research output: Contribution to journalReview article

    2013

    Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

    Fan, Z., Sun, Y., Di Chen, C., Tay, D., Chen, W., Deng, C. X. & Fu, J., 2013, In : Scientific reports. 3, 2176.

    Research output: Contribution to journalArticle

    Adhesion strength-based, label-free isolation of human pluripotent stem cells

    Singh, A., Suri, S., Lee, T., Chilton, J. M., Cooke, M. T., Chen, W., Fu, J., Stice, S. L., Lu, H., McDevitt, T. C. & García, A. J., May 2013, In : Nature methods. 10, 5, p. 438-444 7 p.

    Research output: Contribution to journalArticle

    Capture circulating tumor cells on glass

    Chen, W., Weng, S., Allen, S., Merajver, S. D. & Fu, J., 2013, The 2013 University of Michigan Annual Symposium of the Microfluidics in Biomedical Sciences Training Program, Ann Arbor, MI, May 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Emerging microfluidic tools for functional cellular immunophenotyping: A new potential paradigm for immune status characterization

    Chen, W., Huang, N. T., Li, X., Yu, Z. T. F., Kurabayashi, K. & Fu, J., 2013, In : Frontiers in Oncology. 3 APR, Article 00098.

    Research output: Contribution to journalShort survey

    Integrated microfluidic platform for efficient isolation and functional immunophenotyping of subpopulations of immune cells

    Chen, W., Huang, N., Oh, B., Kurabayashi, K. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Localized surface plasmon resonance (LSPR) optofluidic biosensor for label-free cellular immunophenotyping

    Oh, B. R., Huang, N. T., Chen, W., Seo, J., Fu, J. & Kurabayashi, K., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, p. 92-94 3 p. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; vol. 1).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity

    Chen, W., Sun, Y. & Fu, J., Jan 14 2013, In : Small. 9, 1, p. 81-89 9 p.

    Research output: Contribution to journalArticle

    Microfluidic immunophenotyping assay platform for immunomonitoring of subpopulations of immune cells

    Chen, W., Huang, N., Oh, B., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, p. 1761-1763 3 p. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; vol. 3).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

    Chen, W., Weng, S., Zhang, F., Allen, S., Li, X., Bao, L., Lam, R. H. W., MacOska, J. A., Merajver, S. D. & Fu, J., Jan 22 2013, In : ACS nano. 7, 1, p. 566-575 10 p.

    Research output: Contribution to journalArticle

    Nanotopographic surface for efficient capture of circulating tumor cells

    Chen, W., Weng, S. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

    Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced Healthcare Materials. 2, 7, p. 965-975 11 p.

    Research output: Contribution to journalArticle

    2012

    An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

    Huang, N-T., Chen, W., Oh, B-R., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 20, p. 4093-4101

    Research output: Contribution to journalArticle

    An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

    Huang, N. T., Chen, W., Oh, B. R., Fu, J. & Kurabayashi, K., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 989-991 3 p. (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

    Lam, R. H. W., Sun, Y., Chen, W. & Fu, J., Apr 24 2012, In : Lab on a Chip. 12, 10, p. 1865-1873 9 p.

    Research output: Contribution to journalArticle

    In silico experimentation of glioma microenvironment development and anti-tumor therapy

    Wu, Y., Lu, Y., Chen, W., Fu, J. & Fan, R., Feb 2012, In : PLoS computational biology. 8, 2, e1002355.

    Research output: Contribution to journalArticle