Yi Ye

2025

Integrating priorities at the intersection of cancer and neuroscience

Hwang, W. L., Perrault, E. N., Birbrair, A., Mattson, B. J., Gutmann, D. H., Mabbott, D. J., Cukierman, E., Repasky, E. A., Sloan, E. K., Zong, H., Demir, I. E., Saloman, J. L., Borniger, J. C., Hu, J., Dietrich, J., Breunig, J. J., Çifcibaşı, K., Ahmad Kasm, K. A., Valiente, M. & Wintermark, M. & 12 others, Acharya, M. M., Scheff, N. N., D'Silva, N. J., Vermeer, P. D., Wong, R. J., Talbot, S., Hervey-Jumper, S. L., Wang, T. C., Ye, Y., Pan, Y., Bunimovich, Y. L. & Amit, M., Jan 13 2025, In: Cancer Cell. 43, 1, p. 1-5 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

2024

Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma

Viet, C. T., Asam, K. R., Yu, G., Dyer, E. C., Kochanny, S., Thomas, C. M., Callahan, N. F., Morlandt, A. B., Cheng, A. C., Patel, A. A., Roden, D. F., Young, S., Melville, J., Shum, J., Walker, P. C., Nguyen, K. K., Kidd, S. N., Lee, S. C., Folk, G. S. & Viet, D. T. & 6 others, Grandhi, A., Deisch, J., Ye, Y., Momen-Heravi, F., Pearson, A. T. & Aouizerat, B. E., Dec 2024, In: npj Precision Oncology. 8, 1, 130.

Research output: Contribution to journal › Article › peer-review

Open Access

Delayed Tooth Development and the Impaired Differentiation of Stem/Progenitor Cells in Incisors from Type 2 Diabetes Mice

Kobayashi, Y., Huang, J., Barnett, B. K., Falcon, C. Y., Falcon, P. A., Hirschberg, C. S., Fine, D. H., Ye, Y. & Shimizu, E., Dec 2024, In: International journal of molecular sciences. 25, 24, 13619.

Research output: Contribution to journal › Article › peer-review

Open Access

Perineural Invasion Is Associated With Function-evoked Pain and Altered Extracellular Matrix in Patients With Head and Neck Squamous Cell Carcinoma

Santi, M. D., Zhang, M., Asam, K., Yu, G., Dong, P. M., Sheehan, D. H., Aouizerat, B. E., Thomas, C. M., Viet, C. T. & Ye, Y., Oct 2024, In: Journal of Pain. 25, 10, 104615.

Research output: Contribution to journal › Article › peer-review

Single-Cell Molecular Profiling of Head and Neck Squamous Cell Carcinoma Reveals Five Dysregulated Signaling Pathways Associated With Circulating Tumor Cells

Stucky, A., Viet, C. T., Aouizerat, B. E., Ye, Y., Doan, C., Mundluru, T., Sedhiazadeh, P., Sinha, U. K., Chen, X., Zhang, X., Li, S. C., Cai, J. & Zhong, J. F., Jan 1 2024, In: Cancer Control. 31

Research output: Contribution to journal › Article › peer-review

Open Access

Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma

Dong, M. P., Dharmaraj, N., Kaminagakura, E., Xue, J., Leach, D. G., Hartgerink, J. D., Zhang, M., Hanks, H. J., Ye, Y., Aouizerat, B. E., Vining, K., Thomas, C. M., Dovat, S., Young, S. & Viet, C. T., Apr 2024, In: Biomedicines. 12, 4, 920.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A pilot study to improve pain phenotyping in head and neck cancer patients

Ye, Y., Cardoso, D. D. M., Kayahara, G. M. & Bernabé, D. G., 2023, In: Frontiers in Pain Research. 4, 1146667.

Research output: Contribution to journal › Article › peer-review

Open Access

Repurposing EGFR Inhibitors for Oral Cancer Pain and Opioid Tolerance

Santi, M. D., Zhang, M., Liu, N., Viet, C. T., Xie, T., Jensen, D. D., Amit, M., Pan, H. & Ye, Y., Nov 2023, In: Pharmaceuticals. 16, 11, 1558.

Research output: Contribution to journal › Review article › peer-review

Open Access

Targeting the Nerve–Cancer Circuit

Ye, Y., Xie, T. & Amit, M., Aug 1 2023, In: Cancer Research. 83, 15, p. 2445-2447 3 p.

Research output: Contribution to journal › Article › peer-review

The Ca²⁺ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain

Son, G. Y., Tu, N. H., Santi, M. D., Lopez, S. L., Souza Bomfim, G. H., Vinu, M., Zhou, F., Chaloemtoem, A., Alhariri, R., Idaghdour, Y., Khanna, R., Ye, Y. & Lacruz, R. S., 2023, In: Science signaling. 16, 801, eadf9535.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Advances in Head and Neck Cancer Pain

Ye, Y., Jensen, D. D., Viet, C. T., Pan, H. L., Campana, W. M., Amit, M. & Boada, M. D., Aug 2022, In: Journal of dental research. 101, 9, p. 1025-1033 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer

Yaman, I., Çobanoğlu, D. A., Xie, T., Ye, Y. & Amit, M., Nov 2022, In: Pharmacology and Therapeutics. 239, 108199.

Research output: Contribution to journal › Review article › peer-review

Open Access

Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study

Gonzalez Marrero, Y., Kobayashi, Y., Ihsan, M. S., Pilch, L. A., Chen, L., Jiang, S., Ye, Y., Fine, D. H., Falcon, C. Y., Falcon, P. A., Hirschberg, C. S. & Shimizu, E., Feb 2022, In: Journal of endodontics. 48, 2, p. 208-212.e3

Research output: Contribution to journal › Article › peer-review

Open Access

Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology

Amit, M., Xie, T., Gleber-Netto, F. O., Hunt, P. J., Mehta, G. U., Bell, D., Silverman, D. A., Yaman, I., Ye, Y., Burks, J. K., Fuller, G. N., Gidley, P. W., Nader, M. E., Raza, S. M. & DeMonte, F., Dec 2022, In: Journal of Experimental and Clinical Cancer Research. 41, 1, 292.

Research output: Contribution to journal › Article › peer-review

Open Access

Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer

Doan, C., Aouizerat, B. E., Ye, Y., Dang, D., Asam, K., Bhattacharya, A., Howard, T., Patel, Y. K., Viet, D. T., Figueroa, J. D., Zhong, J. F., Thomas, C. M., Morlandt, A. B., Yu, G., Callahan, N. F., Allen, C. T., Grandhi, A., Herford, A. S., Walker, P. C. & Nguyen, K. & 5 others, Kidd, S. C., Lee, S. C., Inman, J. C., Slater, J. M. & Viet, C. T., Sep 2022, In: Advanced Biology. 6, 9, 2200190.

Research output: Contribution to journal › Article › peer-review

Open Access

Peroxisome proliferator-activated receptor gamma agonist ELB00824 suppresses oxaliplatin-induced pain, neuronal hypersensitivity, and oxidative stress

Zhang, M., Hu, M., Alles, S. R. A., Montera, M. A., Adams, I., Santi, M. D., Inoue, K., Tu, N. H., Westlund, K. N. & Ye, Y., Nov 1 2022, In: Neuropharmacology. 218, 109233.

Research output: Contribution to journal › Article › peer-review

Open Access

Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells

Santi, M. D., Zhang, M., Salvo, E., Asam, K., Viet, C. T., Xie, T., Amit, M., Aouizerat, B. & Ye, Y., Sep 2022, In: Advanced Biology. 6, 9, 2200187.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Glia and orofacial pain: Progress and future directions

Ye, Y., Salvo, E., Romero-Reyes, M., Akerman, S., Shimizu, E., Kobayashi, Y., Michot, B. & Gibbs, J., May 2 2021, In: International journal of molecular sciences. 22, 10, 5345.

Research output: Contribution to journal › Review article › peer-review

Open Access

TNFα promotes oral cancer growth, pain, and Schwann cell activation

Salvo, E., Tu, N. H., Scheff, N. N., Dubeykovskaya, Z. A., Chavan, S. A., Aouizerat, B. E. & Ye, Y., Dec 2021, In: Scientific reports. 11, 1, 1840.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain

Scheff, N. N., Ye, Y., Conley, Z. R., Quan, J. W., Ronald Lam, Y. V., Klares, R., Singh, K., Schmidt, B. L. & Aouizerat, B. E., Oct 1 2020, In: Pain. 161, 10, p. 2330-2343 14 p.

Research output: Contribution to journal › Article › peer-review

Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion

Salvo, E., Campana, W. M., Scheff, N. N., Nguyen, T. H., Jeong, S. H., Wall, I., Wu, A. K., Zhang, S., Kim, H., Bhattacharya, A., Janal, M. N., Liu, C., Albertson, D. G., Schmidt, B. L., Dolan, J. C., Schmidt, R. E., Danilo Boada, M. & Ye, Y., Nov 1 2020, In: Pain. 161, 11, p. 2592-2602 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting the endothelin axis as a therapeutic strategy for oral cancer metastasis and pain

Dang, D., Ye, Y., Aouizerat, B. E., Patel, Y. K., Viet, D. T., Chan, K. C., Ono, K., Doan, C., Figueroa, J. D., Yu, G. & Viet, C. T., Dec 2020, In: Scientific reports. 10, 1, 20832.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Reciprocal interactions between cancer and Schwann cells contribute to oral cancer progression and pain

Salvo, E., Saraithong, P., Curtin, J. G., Janal, M. N. & Ye, Y., Feb 2019, In: Heliyon. 5, 2, e01223.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma

Ye, Y., Scheff, N. N., Bernabé, D., Salvo, E., Ono, K., Liu, C., Veeramachaneni, R., Viet, C. T., Viet, D. T., Dolan, J. C. & Schmidt, B. L., Sep 1 2018, In: Neuropharmacology. 139, p. 182-193 12 p.

Research output: Contribution to journal › Article › peer-review

2017

Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice

Ye, Y., Bernabé, D. G., Salvo, E., Viet, C. T., Ono, K., Dolan, J. C., Janal, M., Aouizerat, B. E., Miaskowski, C. & Schmidt, B. L., Nov 5 2017, In: Neuroscience. 363, p. 50-61 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

Ono, K., Viet, C. T., Ye, Y., Dang, D., Hitomi, S., Toyono, T., Inenaga, K., Dolan, J. C. & Schmidt, B. L., Dec 1 2017, In: Scientific reports. 7, 1, 9181.

Research output: Contribution to journal › Article › peer-review

Open Access

Ex vivo nonviral gene delivery of μ-opioid receptor to attenuate cancer-induced pain

Yamano, S., Viet, C. T., Dang, D., Dai, J., Hanatani, S., Takayama, T., Kasai, H., Imamura, K., Campbell, R., Ye, Y., Dolan, J. C., Kwon, W. M., Schneider, S. D. & Schmidt, B. L., Feb 1 2017, In: Pain. 158, 2, p. 240-251 12 p.

Research output: Contribution to journal › Article › peer-review

OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients

Viet, C. T., Dang, D., Aouizerat, B. E., Miaskowski, C., Ye, Y., Viet, D. T., Ono, K. & Schmidt, B. L., Sep 2017, In: Journal of Pain. 18, 9, p. 1046-1059 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation

Scheff, N. N., Ye, Y., Bhattacharya, A., MacRae, J., Hickman, D. N., Sharma, A. K., Dolan, J. C. & Schmidt, B. L., 2017, In: Pain. 158, 12, p. 2396-2409 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Cancer and Referred Facial Pain

Romero-Reyes, M., Teruel, A. & Ye, Y., Aug 20 2015, In: Current Pain and Headache Reports. 19, 8, 37.

Research output: Contribution to journal › Review article › peer-review

TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity

Ono, K., Ye, Y., Viet, C. T., Dang, D. & Schmidt, B. L., May 1 2015, In: Journal of neurophysiology. 113, 9, p. 3345-3355 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

Open Access

IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma

Ye, Y., Bae, S. S., Viet, C. T., Troob, S., Bernabé, D. & Schmidt, B. L., Feb 13 2014, In: Behavioral and Brain Functions. 10, 1, 5.

Research output: Contribution to journal › Article › peer-review

2013

Pearls and pitfalls in experimental in vivo models of headache: Conscious behavioral research

Romero-Reyes, M. & Ye, Y., Jun 2013, In: Cephalalgia. 33, 8, p. 566-576 11 p.

Research output: Contribution to journal › Article › peer-review

2012

Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity

Ye, Y., Dang, D., Viet, C. T., Dolan, J. C. & Schmidt, B. L., Jun 2012, In: Journal of Pain. 13, 6, p. 524-531 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

Nerve growth factor links oral cancer progression, pain, and cachexia

Ye, Y., Dang, D., Zhang, J., Viet, C. T., Lam, D. K., Dolan, J. C., Gibbs, J. L. & Schmidt, B. L., Sep 2011, In: Molecular Cancer Therapeutics. 10, 9, p. 1667-1676 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain

Viet, C. T., Ye, Y., Dang, D., Lam, D. K., Achdjian, S., Zhang, J. & Schmidt, B. L., Oct 2011, In: Pain. 152, 10, p. 2323-2332 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Early postnatal loss of heat sensitivity among cutaneous myelinated nonciciptors in Swiss-Webster mice

Ye, Y. & Woodbury, C. J., 2010, In: Journal of Neurophysiology. 103, 3, p. 1385-96

Research output: Contribution to journal › Article › peer-review

2009

Dietary omega-3 fatty acids differentially influence ova release and ovarian COX-1 and COX-2 expression in rats

Broughton, K. S., Rule, D. C., Ye, Y., Zhang, X., Driscoll, M. & Culver, B., 2009, In: Nutrition Research. 29, 3, p. 197-205

Research output: Contribution to journal › Article › peer-review

2001

NGF links oral cancer pain and cachexia in a mouse model

Ye, Y., Dang, D., Zhang, J., Viet, C. T., Lam, D. K., Dolan, J., Gibbs, J. L. & Schmidt, B., 2001, In: Molecular Cancer Therapeutics. 10, 9, p. 1667-76

Research output: Contribution to journal › Article › peer-review

Yi Ye

Research output

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