α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers

Harry C. Wang; Miki Kurimoto; Bart Kahr; Jean Chmielewski

doi:10.1016/s0968-0896(01)00129-8

α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers

Harry C. Wang, Miki Kurimoto, Bart Kahr, Jean Chmielewski

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Single crystals of a-lactose monohydrate show a remarkable tendency to include biopolymers, such as proteins, olig-nucleotides and dextrans, within the growing lattice. Glycosylation increased the amount of protein contained within the crystals. The guest molecules were found only within the (010) growth sector of the hatchet shaped crystals, thereby binding preferentially to one of the seven developed crystal faces. The topographical features of the active surface are described.

Original language	English (US)
Pages (from-to)	2279-2283
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/s0968-0896(01)00129-8
State	Published - 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/s0968-0896(01)00129-8

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title = "α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers",

abstract = "Single crystals of a-lactose monohydrate show a remarkable tendency to include biopolymers, such as proteins, olig-nucleotides and dextrans, within the growing lattice. Glycosylation increased the amount of protein contained within the crystals. The guest molecules were found only within the (010) growth sector of the hatchet shaped crystals, thereby binding preferentially to one of the seven developed crystal faces. The topographical features of the active surface are described.",

author = "Wang, {Harry C.} and Miki Kurimoto and Bart Kahr and Jean Chmielewski",

note = "Funding Information: The authors are grateful to the National Institutes of Health (GM58102-01) for their support of this work. M.K. thanks the University of Washington Center for Nanotechnology for fellowship support. ",

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AU - Wang, Harry C.

AU - Kurimoto, Miki

AU - Kahr, Bart

AU - Chmielewski, Jean

N1 - Funding Information: The authors are grateful to the National Institutes of Health (GM58102-01) for their support of this work. M.K. thanks the University of Washington Center for Nanotechnology for fellowship support.

PY - 2001

Y1 - 2001

N2 - Single crystals of a-lactose monohydrate show a remarkable tendency to include biopolymers, such as proteins, olig-nucleotides and dextrans, within the growing lattice. Glycosylation increased the amount of protein contained within the crystals. The guest molecules were found only within the (010) growth sector of the hatchet shaped crystals, thereby binding preferentially to one of the seven developed crystal faces. The topographical features of the active surface are described.

AB - Single crystals of a-lactose monohydrate show a remarkable tendency to include biopolymers, such as proteins, olig-nucleotides and dextrans, within the growing lattice. Glycosylation increased the amount of protein contained within the crystals. The guest molecules were found only within the (010) growth sector of the hatchet shaped crystals, thereby binding preferentially to one of the seven developed crystal faces. The topographical features of the active surface are described.

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ER -

α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers

Abstract

ASJC Scopus subject areas

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