α-Lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers

Harry C. Wang, Miki Kurimoto, Bart Kahr, Jean Chmielewski

Research output: Contribution to journalArticle

Abstract

Single crystals of a-lactose monohydrate show a remarkable tendency to include biopolymers, such as proteins, olig-nucleotides and dextrans, within the growing lattice. Glycosylation increased the amount of protein contained within the crystals. The guest molecules were found only within the (010) growth sector of the hatchet shaped crystals, thereby binding preferentially to one of the seven developed crystal faces. The topographical features of the active surface are described.

Original languageEnglish (US)
Pages (from-to)2279-2283
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume9
Issue number9
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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