心臓拍動を模倣する流体キャパシタを集積した肝臓オルガノイド作製用マイクロ流体デバイス

Translated title of the contribution: Novel microfluidic device integrated with a fluidic-capacitor to mimic heart beating for generation of functional liver organoids

Jiaxu Wu, Yoshikazu Hirai, Ken Ichiro Kamei, Toshiyuki Tsuchiya, Osamu Tabata

Research output: Contribution to journalArticlepeer-review

Abstract

Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, conventional methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle these issues, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic-based cell culture platform integrating a fluidic capacitor to produce pressure stimuli with hydrostatic pressure. Furthermore, we demonstrate a numerical simulation based on equivalent circuit model for designing the device parameters with sufficient accuracy. This device concept will provide insights into physical micro-environmental regulation on organoid development.

Translated title of the contributionNovel microfluidic device integrated with a fluidic-capacitor to mimic heart beating for generation of functional liver organoids
Original languageUndefined
Pages (from-to)209-216
Number of pages8
JournalIEEJ Transactions on Sensors and Micromachines
Volume139
Issue number7
DOIs
StatePublished - 2019

Keywords

  • Equivalent circuit model
  • Fluidic capacitor
  • Organoid
  • Polydimethylsiloxane
  • Pressure stimulus

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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