1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana

Carlos Alonso-Blanco, Jorge Andrade, Claude Becker, Felix Bemm, Joy Bergelson, Karsten M M. Borgwardt, Jun Cao, Eunyoung Chae, Todd M M. Dezwaan, Wei Ding, Joseph R R. Ecker, Moises Exposito-Alonso, Ashley Farlow, Joffrey Fitz, Xiangchao Gan, Dominik G G. Grimm, Angela M M. Hancock, Stefan R R. Henz, Svante Holm, Matthew HortonMike Jarsulic, Randall A A. Kerstetter, Arthur Korte, Pamela Korte, Christa Lanz, Cheng Ruei Lee, Dazhe Meng, Todd P P. Michael, Richard Mott, Ni Wayan W. Muliyati, Thomas Nägele, Matthias Nagler, Viktoria Nizhynska, Magnus Nordborg, Polina Yu Y. Novikova, F.  Xavier Picó, Alexander Platzer, Fernando A A. Rabanal, Alex Rodriguez, Beth A A. Rowan, Patrice A A. Salomé, Karl J J. Schmid, Robert J J. Schmitz, Ümit Seren, Felice Gianluca G. Sperone, Mitchell Sudkamp, Hannes Svardal, Matt M M. Tanzer, Donald Todd, Samuel L L. Volchenboum, Congmao Wang, George Wang, Xi Wang, Wolfram Weckwerth, Detlef Weigel, Xuefeng Zhou

Research output: Contribution to journalArticlepeer-review


Arabidopsis thaliana serves as a model organism for the study of fundamental physiological, cellular, and molecular processes. It has also greatly advanced our understanding of intraspecific genome variation. We present a detailed map of variation in 1,135 high-quality re-sequenced natural inbred lines representing the native Eurasian and North African range and recently colonized North America. We identify relict populations that continue to inhabit ancestral habitats, primarily in the Iberian Peninsula. They have mixed with a lineage that has spread to northern latitudes from an unknown glacial refugium and is now found in a much broader spectrum of habitats. Insights into the history of the species and the fine-scale distribution of genetic diversity provide the basis for full exploitation of A. thaliana natural variation through integration of genomes and epigenomes with molecular and non-molecular phenotypes.

Original languageEnglish (US)
Pages (from-to)481-491
Number of pages11
Issue number2
StatePublished - Jul 14 2016


  • 1001 Genomes
  • Arabidopsis thaliana
  • GWAS
  • glacial refugia
  • population expansion

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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