3D-printed herringbone micro-mixers for immuno-capture of cancer cells

Pavithra Sukumar, Muhammedin Deliorman, Ayoola Brimmo, Roaa Alnemari, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work presents a method for fabricating herringbone micro-mixers using stereo-lithographic 3D printing for scalable, versatile, and efficient capture of cancer cells from peripheral blood samples. The 3D-printed herringbones were confirmed to create chaotic mixing patterns within the channel, both by 3D finite element analysis and experiments. Experiments showed ∼61% capture efficiency of MCF-7 breast cancer cells using immobilized anti-EpCAM antibodies. Simulations also suggested that 2- and 5× scaled herringbone micro-mixers can be used for high throughput applications. Fabricating scaled-up versions of herringbone micro-mixers can be achieved easily by modifying, on demand, CAD design before 3D printing and PDMS molding.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages2441-2442
Number of pages2
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • 3D printing
  • Circulating tumor cells
  • Herringbone micro-mixers
  • Liquid biopsy
  • Microfluidics

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Sukumar, P., Deliorman, M., Brimmo, A., Alnemari, R., & Qasaimeh, M. A. (2018). 3D-printed herringbone micro-mixers for immuno-capture of cancer cells. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 2441-2442). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 4). Chemical and Biological Microsystems Society.