3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy

Clément Orczyk, Andrew B. Rosenkrantz, Artem Mikheev, Arnauld Villers, Myriam Bernaudin, Samir S. Taneja, Samuel Valable, Henry Rusinek

Research output: Contribution to journalArticlepeer-review


Rationale and Objectives This study aimed to assess a novel method of three-dimensional (3D) co-registration of prostate magnetic resonance imaging (MRI) examinations performed before and after prostate cancer focal therapy. Materials and Methods We developed a software platform for automatic 3D deformable co-registration of prostate MRI at different time points and applied this method to 10 patients who underwent focal ablative therapy. MRI examinations were performed preoperatively, as well as 1 week and 6 months post treatment. Rigid registration served as reference for assessing co-registration accuracy and precision. Results Segmentation of preoperative and postoperative prostate revealed a significant postoperative volume decrease of the gland that averaged 6.49 cc (P =.017). Applying deformable transformation based on mutual information from 120 pairs of MRI slices, we refined by 2.9 mm (max. 6.25 mm) the alignment of the ablation zone, segmented from contrast-enhanced images on the 1-week postoperative examination, to the 6-month postoperative T2-weighted images. This represented a 500% improvement over the rigid approach (P =.001), corrected by volume. The dissimilarity by Dice index of the mapped ablation zone using deformable transformation vs rigid control was significantly (P =.04) higher at the ablation site than in the whole gland. Conclusions Our findings illustrate our method's ability to correct for deformation at the ablation site. The preliminary analysis suggests that deformable transformation computed from mutual information of preoperative and follow-up MRI is accurate in co-registration of MRI examinations performed before and after focal therapy. The ability to localize the previously ablated tissue in 3D space may improve targeting for image-guided follow-up biopsy within focal therapy protocols.

Original languageEnglish (US)
Pages (from-to)1544-1555
Number of pages12
JournalAcademic Radiology
Issue number12
StatePublished - Dec 2017


  • MRI
  • Prostate cancer
  • biopsy
  • deformable registration
  • focal therapy
  • image processing
  • longitudinal follow-up
  • three dimensional

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of '3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy'. Together they form a unique fingerprint.

Cite this