A 0.18-μ m CMOS array sensor for integrated time-resolved fluorescence detection

Ta Chien D. Huang, Sebastian Sorgenfrei, Ping Gong, Rastislav Levicky, Kenneth L. Shepard

Research output: Contribution to journalArticle

Abstract

This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 × 106 photons/cm2 with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.

Original languageEnglish (US)
Article number4907340
Pages (from-to)1644-1654
Number of pages11
JournalIEEE Journal of Solid-State Circuits
Volume44
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Biosensor
  • CMOS image sensor
  • Fluorescence
  • Microarray

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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