A 0.18-μ m CMOS array sensor for integrated time-resolved fluorescence detection

Ta Chien D. Huang; Sebastian Sorgenfrei; Ping Gong; Rastislav Levicky; Kenneth L. Shepard

doi:10.1109/JSSC.2009.2016994

A 0.18-μ m CMOS array sensor for integrated time-resolved fluorescence detection

Ta Chien D. Huang, Sebastian Sorgenfrei, Ping Gong, Rastislav Levicky, Kenneth L. Shepard

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 × 10⁶ photons/cm² with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.

Original language	English (US)
Article number	4907340
Pages (from-to)	1644-1654
Number of pages	11
Journal	IEEE Journal of Solid-State Circuits
Volume	44
Issue number	5
DOIs	https://doi.org/10.1109/JSSC.2009.2016994
State	Published - May 2009

Keywords

Biosensor
CMOS image sensor
Fluorescence
Microarray

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1109/JSSC.2009.2016994

Cite this

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title = "A 0.18-μ m CMOS array sensor for integrated time-resolved fluorescence detection",

abstract = "This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 × 106 photons/cm2 with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.",

keywords = "Biosensor, CMOS image sensor, Fluorescence, Microarray",

author = "Huang, {Ta Chien D.} and Sebastian Sorgenfrei and Ping Gong and Rastislav Levicky and Shepard, {Kenneth L.}",

note = "Funding Information: Manuscript received August 08, 2008; revised December 30, 2008. Current version published May 01, 2009. This work was supported in part by Award Number R33HG003089 from the National Human Genome Research Institute, and in part by the National Science Foundation under Grant BES-428544, by NYSTAR, and by the C2S2 Focus Center Research Program.",

year = "2009",

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doi = "10.1109/JSSC.2009.2016994",

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AU - Gong, Ping

AU - Levicky, Rastislav

AU - Shepard, Kenneth L.

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A 0.18-μ m CMOS array sensor for integrated time-resolved fluorescence detection

Abstract

Keywords

ASJC Scopus subject areas

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