TY - JOUR
T1 - A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay
AU - Oliveira, Maria Laura Cosetti
AU - Wagner, Vivian Petersen
AU - Filho, Manoel Sant’Ana
AU - Carrard, Vinicius Coelho
AU - Hugo, Fernando Neves
AU - Martins, Manoela Domingues
N1 - Publisher Copyright:
© 2015,Brazilian Oral Research.All Rights Reserved.
PY - 2015
Y1 - 2015
N2 - The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher’s tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
AB - The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher’s tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
KW - Delayed Diagnosis
KW - Epidemiology
KW - Mouth Neoplasms
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84976877044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976877044&partnerID=8YFLogxK
U2 - 10.1590/1807-3107BOR-2015.vol29.0075
DO - 10.1590/1807-3107BOR-2015.vol29.0075
M3 - Article
C2 - 26083090
AN - SCOPUS:84976877044
SN - 1806-8324
VL - 29
SP - 1
EP - 8
JO - Brazilian Oral Research
JF - Brazilian Oral Research
IS - 1
ER -