A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

Andrew G. Jamieson, David Russell, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

Original languageEnglish (US)
Pages (from-to)3709-3711
Number of pages3
JournalChemical Communications
Volume48
Issue number31
DOIs
StatePublished - Mar 19 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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