A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Eugene Lih; Wooram Park; Ki Wan Park; So Young Chun; Hyuncheol Kim; Yoon Ki Joung; Tae Gyun Kwon; Jeffrey A. Hubbell; Dong Keun Han

doi:10.1021/acscentsci.8b00812

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Eugene Lih, Wooram Park, Ki Wan Park, So Young Chun, Hyuncheol Kim, Yoon Ki Joung, Tae Gyun Kwon, Jeffrey A. Hubbell, Dong Keun Han

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) ₂ ), and decellularized renal extracellular matrix (ECM). The Mg(OH) ₂ inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) ₂ scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) ₂ scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

Original language	English (US)
Pages (from-to)	458-467
Number of pages	10
Journal	ACS Central Science
Volume	5
Issue number	3
DOIs	https://doi.org/10.1021/acscentsci.8b00812
State	Published - Mar 27 2019

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration",

abstract = " Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.",

author = "Eugene Lih and Wooram Park and Park, {Ki Wan} and Chun, {So Young} and Hyuncheol Kim and Joung, {Yoon Ki} and Kwon, {Tae Gyun} and Hubbell, {Jeffrey A.} and Han, {Dong Keun}",

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doi = "10.1021/acscentsci.8b00812",

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AU - Lih, Eugene

AU - Park, Wooram

AU - Park, Ki Wan

AU - Chun, So Young

AU - Kim, Hyuncheol

AU - Joung, Yoon Ki

AU - Kwon, Tae Gyun

AU - Hubbell, Jeffrey A.

AU - Han, Dong Keun

PY - 2019/3/27

Y1 - 2019/3/27

N2 - Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

AB - Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide-co-glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

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A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

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