A C version of Fourier-derived affinity spectrum analysis (FASA) to resolve binding heterogeneity

Jeffrey I. Mechanick, Charles S. Peskin

Research output: Contribution to journalArticlepeer-review

Abstract

The computer program described in this paper facilitates resolution of binding affinity heterogeneity by transforming binding curve data (bound versus free) into affinity spectra (density versus affinity). The original program, written in FORTRAN, is extended and presented here in the language C. New applications include an ability to transform competition curves into affinity spectra and to evaluate the effects of sampling and experimental error on spectrum analysis. We propose that this program be incorporated in the routine evaluation of binding systems.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalBioinformatics
Volume6
Issue number3
DOIs
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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