@article{e07a29e16ee344388f0205606ef2b93f,
title = "A Causal Network Analysis of Neuromodulation in the Mood Processing Network",
abstract = "Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication, whereas sbTetMS neuromodulation temporarily disrupted sender-receiver communication. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication.",
keywords = "causal network analysis, modulator decoding, multiregional communication, network edge neuromodulation, network excitability",
author = "Shaoyu Qiao and Sedillo, {J. Isaac} and Brown, {Kevin A.} and Breonna Ferrentino and Bijan Pesaran",
note = "Funding Information: We would like to thank Baldwin Goodell, Charles Gray, Jessica Kleinbart, and Amy Orsborn for assistance with chamber and microdrive system design; Stephen Frey and Brian Hynes for custom modifications to the Brainsight system; Keith Sanzenbach and Pablo Velasco from the NYU Center for Imaging for help with magnetic resonance imaging and diffusion weighted imaging; and Ryan Shewcraft, John Choi, Marsela Rubiano, Yoohee Jang, Octavia Martin, and the NYU Office of Veterinary Resources for help with animal preparation and care. This work was supported in part by the Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement W911NF-14-2-0043 , issued by the Army Research Office contracting office in support of DARPA{\textquoteright}s SUBNETS program (to B.P.). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. This work was also supported in part by an award from the Simons Collaboration on the Global Brain (to B.P.) and National Institutes of Health (NIH) BRAIN grant R01-NS104923 (to B.P.). Funding Information: We would like to thank Baldwin Goodell, Charles Gray, Jessica Kleinbart, and Amy Orsborn for assistance with chamber and microdrive system design; Stephen Frey and Brian Hynes for custom modifications to the Brainsight system; Keith Sanzenbach and Pablo Velasco from the NYU Center for Imaging for help with magnetic resonance imaging and diffusion weighted imaging; and Ryan Shewcraft, John Choi, Marsela Rubiano, Yoohee Jang, Octavia Martin, and the NYU Office of Veterinary Resources for help with animal preparation and care. This work was supported in part by the Defense Advanced Research Projects Agency (DARPA) under Cooperative Agreement W911NF-14-2-0043, issued by the Army Research Office contracting office in support of DARPA's SUBNETS program (to B.P.). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. This work was also supported in part by an award from the Simons Collaboration on the Global Brain (to B.P.) and National Institutes of Health (NIH) BRAIN grant R01-NS104923 (to B.P.). Conceptualization, S.Q. and B.P.; Methodology, S.Q. and B.P.; Investigation, S.Q. J.I.S. K.A.B. B.F. and B.P.; Formal Analysis, S.Q. and B.P.; Writing ? Original Draft, S.Q. and B.P.; Writing ? Review & Editing, S.Q. and B.P.; Funding Acquisition, B.P.; Supervision, B.P. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = sep,
day = "9",
doi = "10.1016/j.neuron.2020.06.012",
language = "English (US)",
volume = "107",
pages = "972--985.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",
}