A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels

Arun Manickam, Kae Dyi You, Nicholas Wood, Lei Pei, Yang Liu, Rituraj Singh, Nader Gamini, Mark W. McDermott, Davood Shahrjerdi, Robert G. Kuimelis, Arjang Hassibi

Research output: Contribution to journalArticlepeer-review

Abstract

A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.

Original languageEnglish (US)
Article number8869863
Pages (from-to)2980-2990
Number of pages11
JournalIEEE Journal of Solid-State Circuits
Volume54
Issue number11
DOIs
StatePublished - Nov 2019

Keywords

  • Biochip
  • DNA sequencing
  • biosensor
  • electrochemical
  • lab-on-chip
  • microarrays
  • molecular diagnostics (MDx)
  • nucleic acid
  • voltammetry

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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