A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels

Arun Manickam; Kae Dyi You; Nicholas Wood; Lei Pei; Yang Liu; Rituraj Singh; Nader Gamini; Mark W. McDermott; Davood Shahrjerdi; Robert G. Kuimelis; Arjang Hassibi

doi:10.1109/JSSC.2019.2941020

A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels

Arun Manickam, Kae Dyi You, Nicholas Wood, Lei Pei, Yang Liu, Rituraj Singh, Nader Gamini, Mark W. McDermott, Davood Shahrjerdi, Robert G. Kuimelis, Arjang Hassibi

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.

Original language	English (US)
Article number	8869863
Pages (from-to)	2980-2990
Number of pages	11
Journal	IEEE Journal of Solid-State Circuits
Volume	54
Issue number	11
DOIs	https://doi.org/10.1109/JSSC.2019.2941020
State	Published - Nov 2019

Keywords

Biochip
DNA sequencing
biosensor
electrochemical
lab-on-chip
microarrays
molecular diagnostics (MDx)
nucleic acid
voltammetry

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1109/JSSC.2019.2941020

Cite this

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title = "A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels",

abstract = "A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.",

keywords = "Biochip, DNA sequencing, biosensor, electrochemical, lab-on-chip, microarrays, molecular diagnostics (MDx), nucleic acid, voltammetry",

author = "Arun Manickam and You, {Kae Dyi} and Nicholas Wood and Lei Pei and Yang Liu and Rituraj Singh and Nader Gamini and McDermott, {Mark W.} and Davood Shahrjerdi and Kuimelis, {Robert G.} and Arjang Hassibi",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.",

year = "2019",

month = nov,

doi = "10.1109/JSSC.2019.2941020",

language = "English (US)",

volume = "54",

pages = "2980--2990",

journal = "IEEE Journal of Solid-State Circuits",

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AU - Manickam, Arun

AU - You, Kae Dyi

AU - Wood, Nicholas

AU - Pei, Lei

AU - Liu, Yang

AU - Singh, Rituraj

AU - Gamini, Nader

AU - McDermott, Mark W.

AU - Shahrjerdi, Davood

AU - Kuimelis, Robert G.

AU - Hassibi, Arjang

PY - 2019/11

Y1 - 2019/11

N2 - A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.

AB - A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.

KW - Biochip

KW - DNA sequencing

KW - biosensor

KW - electrochemical

KW - lab-on-chip

KW - microarrays

KW - molecular diagnostics (MDx)

KW - nucleic acid

KW - voltammetry

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ER -

A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels

Abstract

Keywords

ASJC Scopus subject areas

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