A comparison of bacterial aggregation induced by saliva, lysozyme, and zinc

E. E. Golub, J. Cheruka, B. Boosz, C. Davis, D. Malamud

    Research output: Contribution to journalArticlepeer-review


    Aggregation of bacteria by zinc and lysozyme was studied and compared with aggregation induced by a high-molecular-weight salivary agglutinin. Each ligand was found to exhibit a unique profile of properties when examined by both a microradiochemical centrifugation assay and a turbidimetric assay. Significant differences in rate of aggregation and bacterial species specificity were noted. Zinc- and lysozyme-mediated aggregations were shown to be calcium independent and to proceed rapidly at 0°C, in contrast to the salivary agglutinin. Zinc produced large, asymmetric aggregates, saliva produced intermediate-sized aggregates, and lysozyme produced the smallest aggregates. These size differences are consistent with many of the observed reaction properties.

    Original languageEnglish (US)
    Pages (from-to)204-210
    Number of pages7
    JournalInfection and Immunity
    Issue number1
    StatePublished - 1985

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Infectious Diseases


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