A comparison of normal submaxillary gland proteins with proteins obtained from a transplantable murine salivary gland carcinoma (myoepithelioma)

David Irwin, Daniel Malamud

Research output: Contribution to journalArticle

Abstract

A new transplantable murine salivary gland carcinoma (myoepithelioma) was further characterized by comparing total protein patterns with normal submaxillary qland proteins. Analysis by isoelectric focussing or by labelling studies with radioactive leucine showed considerable differences between tumour and normal proteins. In contrast, analysis of staining patterns after electrophoresis in sodium dodecyl sulphate containing gels revealed a striking similarity between normal proteins, tumour proteins and proteins obtained from metastatic growths. It thus appears that tumour proteins closely resemble the normal proteins from the tissue of origin with respect to molecular size as determined by electrophoretic mobility, while significant differences occur in charge and labelling kinetics.

Original languageEnglish (US)
Pages (from-to)75-84
Number of pages10
JournalCell Biology International Reports
Volume3
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • Cell Biology

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