A comparison of plasma polymorphonuclear leucocyte elastase levels in obese and lean individuals

E. Adeyemi, S. Benedict, A. Abdulle

Research output: Contribution to journalArticlepeer-review

Abstract

Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalJournal of International Medical Research
Volume26
Issue number5
DOIs
StatePublished - 1998

Keywords

  • Cathepsin G
  • Elastase
  • Myeloperoxidase
  • Obesity
  • Polymorphonuclear leucocyte

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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