A comparison of plasma polymorphonuclear leucocyte elastase levels in obese and lean individuals

E. Adeyemi; S. Benedict; A. Abdulle

doi:10.1177/030006059802600505

A comparison of plasma polymorphonuclear leucocyte elastase levels in obese and lean individuals

E. Adeyemi, S. Benedict, A. Abdulle

Public Health Research Center

Research output: Contribution to journal › Article › peer-review

Abstract

Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	Journal of International Medical Research
Volume	26
Issue number	5
DOIs	https://doi.org/10.1177/030006059802600505
State	Published - 1998

Keywords

Cathepsin G
Elastase
Myeloperoxidase
Obesity
Polymorphonuclear leucocyte

ASJC Scopus subject areas

Biochemistry
Cell Biology
Biochemistry, medical

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10.1177/030006059802600505

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title = "A comparison of plasma polymorphonuclear leucocyte elastase levels in obese and lean individuals",

abstract = "Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).",

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AU - Adeyemi, E.

AU - Benedict, S.

AU - Abdulle, A.

PY - 1998

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N2 - Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).

AB - Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).

KW - Cathepsin G

KW - Elastase

KW - Myeloperoxidase

KW - Obesity

KW - Polymorphonuclear leucocyte

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A comparison of plasma polymorphonuclear leucocyte elastase levels in obese and lean individuals

Abstract

Keywords

ASJC Scopus subject areas

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