A computational investigation of electrotonic coupling between pyramidal cells in the cortex

Jennifer Crodelle, Douglas Zhou, Gregor Kovačič, David Cai

Research output: Contribution to journalArticle

Abstract

The existence of electrical communication among pyramidal cells (PCs) in the adult cortex has been debated by neuroscientists for several decades. Gap junctions (GJs) among cortical interneurons have been well documented experimentally and their functional roles have been proposed by both computational neuroscientists and experimentalists alike. Experimental evidence for similar junctions among pyramidal cells in the cortex, however, has remained elusive due to the apparent rarity of these couplings among neurons. In this work, we develop a neuronal network model that includes observed probabilities and strengths of electrotonic coupling between PCs and gap-junction coupling among interneurons, in addition to realistic synaptic connectivity among both populations. We use this network model to investigate the effect of electrotonic coupling between PCs on network behavior with the goal of theoretically addressing this controversy of existence and purpose of electrotonically coupled PCs in the cortex.

Original languageEnglish (US)
JournalJournal of Computational Neuroscience
DOIs
StateAccepted/In press - 2020

Keywords

  • Gap junctions
  • Hodgkin-Huxley model
  • Neuronal networks
  • Pyramidal cells

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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