A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Michael Hernandez, Yang Hu, Jin Ryoun Kim

Research output: Contribution to journalArticle

Abstract

We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers, which are the major toxic aggregate forms in Parkinson’s disease.

Original languageEnglish (US)
Pages (from-to)10712-10714
Number of pages3
JournalChemical Communications
Volume49
Issue number91
DOIs
StatePublished - Oct 22 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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