A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Michael Hernandez; Yang Hu; Jin Ryoun Kim

doi:10.1039/c3cc44804e

A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Michael Hernandez, Yang Hu, Jin Ryoun Kim

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers, which are the major toxic aggregate forms in Parkinson’s disease.

Original language	English (US)
Pages (from-to)	10712-10714
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	91
DOIs	https://doi.org/10.1039/c3cc44804e
State	Published - Oct 22 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc44804e

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abstract = "We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers, which are the major toxic aggregate forms in Parkinson{\textquoteright}s disease.",

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A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

Abstract

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