A disinhibitory circuit mediates motor integration in the somatosensory cortex

Soohyun Lee; Illya Kruglikov; Z. Josh Huang; Gord Fishell; Bernardo Rudy

doi:10.1038/nn.3544

A disinhibitory circuit mediates motor integration in the somatosensory cortex

Soohyun Lee, Illya Kruglikov, Z. Josh Huang, Gord Fishell, Bernardo Rudy

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of motor activity on sensory processing is crucial for perception and motor execution. However, the underlying circuits are not known. To unravel the circuit by which activity in the primary vibrissal motor cortex (vM1) modulates sensory processing in the primary somatosensory barrel cortex (S1), we used optogenetics to examine the long-range inputs from vM1 to the various neuronal elements in S1. We found that S1-projecting vM1 pyramidal neurons strongly recruited vasointestinal peptide (VIP)-expressing GABAergic interneurons, a subset of serotonin receptor-expressing interneurons. These VIP interneurons preferentially inhibited somatostatin-expressing interneurons, neurons that target the distal dendrites of pyramidal cells. Consistent with this vM1-mediated disinhibitory circuit, the activity of VIP interneurons in vivo increased and that of somatostatin interneurons decreased during whisking. These changes in firing rates during whisking depended on vM1 activity. Our results suggest previously unknown circuitry by which inputs from motor cortex influence sensory processing in sensory cortex.

Original language	English (US)
Pages (from-to)	1662-1670
Number of pages	9
Journal	Nature Neuroscience
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/nn.3544
State	Published - Nov 2013

ASJC Scopus subject areas

General Neuroscience

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title = "A disinhibitory circuit mediates motor integration in the somatosensory cortex",

abstract = "The influence of motor activity on sensory processing is crucial for perception and motor execution. However, the underlying circuits are not known. To unravel the circuit by which activity in the primary vibrissal motor cortex (vM1) modulates sensory processing in the primary somatosensory barrel cortex (S1), we used optogenetics to examine the long-range inputs from vM1 to the various neuronal elements in S1. We found that S1-projecting vM1 pyramidal neurons strongly recruited vasointestinal peptide (VIP)-expressing GABAergic interneurons, a subset of serotonin receptor-expressing interneurons. These VIP interneurons preferentially inhibited somatostatin-expressing interneurons, neurons that target the distal dendrites of pyramidal cells. Consistent with this vM1-mediated disinhibitory circuit, the activity of VIP interneurons in vivo increased and that of somatostatin interneurons decreased during whisking. These changes in firing rates during whisking depended on vM1 activity. Our results suggest previously unknown circuitry by which inputs from motor cortex influence sensory processing in sensory cortex.",

author = "Soohyun Lee and Illya Kruglikov and Huang, {Z. Josh} and Gord Fishell and Bernardo Rudy",

note = "Funding Information: We thank all of the members of the Rudy and Fishell laboratories for helpful discussions. We thank K. Deisseroth (Stanford University) for DIO-ChR2-mCherry plasmids, Z. Talbot for help with intrinsic imaging and setting-up a camera for whisking behavior, and E. Merriam for advice on in vivo data analysis. This work was supported by grants from the US National Institutes of Health (R01 NS30989 and P01 NS074972 to B.R., MH071679 and P01 NS074972 to G.F., and 1F32NS076316 to S.L.). I.K. was supported by Epilepsy Foundation grant 260691.",

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A disinhibitory circuit mediates motor integration in the somatosensory cortex

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