A disinhibitory circuit motif and flexible information routing in the brain

Xiao Jing Wang, Guangyu Robert Yang

Research output: Contribution to journalReview articlepeer-review


In the mammalian neocortex, an area typically receives inputs from, and projects to, dozens of other areas. Mechanisms are needed to flexibly route information to the right place at the right time, which we term ‘pathway gating’. For instance, a region in your brain that receives signals from both visual and auditory pathways may want to ‘gate in’ the visual pathway while ‘gating out’ the auditory pathway when you try to read a book surrounded by people in a noisy café. In this review, we marshall experimental and computational evidence in support of a circuit mechanism for flexible pathway gating realized by a disinhibitory motif. Moreover, recent work shows an increasing preponderance of this disinhibitory motif from sensory areas to association areas of the mammalian cortex. Pathway input gating is briefly compared with alternative or complementary gating mechanisms. Predictions and open questions for future research on this puzzle about the complex brain system will be discussed.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalCurrent Opinion in Neurobiology
StatePublished - Apr 2018

ASJC Scopus subject areas

  • General Neuroscience


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