@inproceedings{5b606243d2634b298f63502d5da3083d,
title = "A disposable microfluidic point-of-care device for the detection of HIV: A new up-converting phosphor technology application",
abstract = "A bench-top analysis protocol to detect HIV-1 antibodies in blood plasma with upconverting phosphor particles (UPT) and lateral flow (LF) was established. A preliminary clinical study demonstrated that the UPT-LF detection successfully identified positive and negative samples. A 104× dilution of a positive clinical sample generated a signal well above the negative control. The bench-top UPT-LF protocol was implemented in a microfluidic chip with functions such as sample introduction, buffer distribution, metering, mixing, and thermo -pneumatic pump ing. The flow control was achieved with phase-change (PC) valves that operated in a self-actuated mode. Preliminary tests of the microfluidic device demonstrated compatibility of the microfluidic chip with UPT-LF detection and produced comparable sensitivity to that of the bench-top test.",
keywords = "HIV detection, Immunoassay, Lab-on-a-chip, Phase-change valve",
author = "Z. Chen and Corstjens, {P. L.A.M.} and M. Zuiderwijk and J. Wang and Mauk, {M. G.} and Bau, {H. H.} and Abrams, {W. R.} and D. Malamud",
year = "2005",
language = "English (US)",
isbn = "0974361119",
series = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Transducer Research Foundation",
pages = "791--793",
booktitle = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference",
note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",
}