A dynamic model of learning in the septo-hippocampal system

Bas Rokers, Catherine E. Myers, Mark A. Gluck

Research output: Contribution to journalConference articlepeer-review


Gluck and Myers (Hippocampus 3 (1993) 491-516) modeled the hippocampus as an auto-encoder; Myers et al. (Neurobiol. Learning Memory 66 (1996) 51-66) argued that the cholinergic input from medial septum modulates learning rate in this auto-encoder. Neurophysiological evidence suggests the hippocampus self-regulates septal acetylcholine release in response to novel stimuli (Hasselmo and Schnell, J. Neurosci. 14 (1994) 3898-3914). We have extended our earlier model of septohippocampal modulation to include such a feedback loop. The resulting dynamic model learns faster and better than the earlier version on phenomena such as blocking and shift reversal. It can also be applied to data regarding the effects of the anticholinergic drug scopolamine. (C) 2000 Elsevier Science B.V. All rights reserved.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
StatePublished - Jun 2000
EventThe 8th Annual Computational Neuroscience Meeting (CNS'99) - Pittsburgh, PA, USA
Duration: Jul 18 1999Jul 22 1999


  • Acetylcholine
  • Hippocampus
  • Model
  • Neuromodulation
  • Septum

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence


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