A feedback control model for cortisol secretion

Rose T. Faghih; Ketan Savla; Munther A. Dahleh; Emery N. Brown

doi:10.1109/IEMBS.2011.6090162

A feedback control model for cortisol secretion

Rose T. Faghih, Ketan Savla, Munther A. Dahleh, Emery N. Brown

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Existing mathematical models for cortisol secretion do not describe the entire cortisol secretion process, from the neural firing of corticotropin releasing hormone (CRH) in the hypothalamus to cortisol concentration in the plasma. In this paper, we lay the groundwork to construct a more comprehensive model, relating CRH, Adrenocorticotropic hormone (ACTH), and cortisol. We start with an existing mathematical model for cortisol secretion, and combine it with a simplified neural firing model that describes CRH and ACTH release. This simplified neural firing model is obtained using the extended FitzHugh-Nagumo (FHN) model, which includes a time-varying spiking threshold [3]. A key feature of our model is the presence of a feedback loop from cortisol secretion to ACTH secretion.

Original language	English (US)
Title of host publication	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages	716-719
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2011.6090162
State	Published - 2011
Event	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States Duration: Aug 30 2011 → Sep 3 2011

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Other

Other	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Country/Territory	United States
City	Boston, MA
Period	8/30/11 → 9/3/11

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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10.1109/IEMBS.2011.6090162

Cite this

Faghih, R. T., Savla, K., Dahleh, M. A., & Brown, E. N. (2011). A feedback control model for cortisol secretion. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 716-719). Article 6090162 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/IEMBS.2011.6090162

A feedback control model for cortisol secretion. / Faghih, Rose T.; Savla, Ketan; Dahleh, Munther A. et al.
33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 716-719 6090162 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Faghih, RT, Savla, K, Dahleh, MA & Brown, EN 2011, A feedback control model for cortisol secretion. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6090162, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 716-719, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6090162

Faghih RT, Savla K, Dahleh MA, Brown EN. A feedback control model for cortisol secretion. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. 2011. p. 716-719. 6090162. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/IEMBS.2011.6090162

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A feedback control model for cortisol secretion

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