A feedback control model for cortisol secretion

Rose T. Faghih, Ketan Savla, Munther A. Dahleh, Emery N. Brown

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Existing mathematical models for cortisol secretion do not describe the entire cortisol secretion process, from the neural firing of corticotropin releasing hormone (CRH) in the hypothalamus to cortisol concentration in the plasma. In this paper, we lay the groundwork to construct a more comprehensive model, relating CRH, Adrenocorticotropic hormone (ACTH), and cortisol. We start with an existing mathematical model for cortisol secretion, and combine it with a simplified neural firing model that describes CRH and ACTH release. This simplified neural firing model is obtained using the extended FitzHugh-Nagumo (FHN) model, which includes a time-varying spiking threshold [3]. A key feature of our model is the presence of a feedback loop from cortisol secretion to ACTH secretion.

    Original languageEnglish (US)
    Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
    Pages716-719
    Number of pages4
    DOIs
    StatePublished - 2011
    Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
    Duration: Aug 30 2011Sep 3 2011

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    ISSN (Print)1557-170X

    Other

    Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
    Country/TerritoryUnited States
    CityBoston, MA
    Period8/30/119/3/11

    ASJC Scopus subject areas

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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