A few disconnected notes related to levinthal paradox

A. Grosberg

    Research output: Contribution to journalArticlepeer-review


    We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.

    Original languageEnglish (US)
    Pages (from-to)317-321
    Number of pages5
    JournalJournal of Biomolecular Structure and Dynamics
    Issue number3
    StatePublished - Dec 2002

    ASJC Scopus subject areas

    • Structural Biology
    • Molecular Biology


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