TY - JOUR
T1 - A few disconnected notes related to levinthal paradox
AU - Grosberg, A.
PY - 2002/12
Y1 - 2002/12
N2 - We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.
AB - We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.
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U2 - 10.1080/07391102.2002.10506848
DO - 10.1080/07391102.2002.10506848
M3 - Article
C2 - 12437368
AN - SCOPUS:0036918484
SN - 0739-1102
VL - 20
SP - 317
EP - 321
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 3
ER -