A generalized semi-automated rational design of micropillar arrays for mechanobiological studies

Christopher J. Stubbs, Samuel O. Sofela, Navajit S. Baban, Yong Ak Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Elastomeric micropillar arrays have found broad applications in mechanobiological studies such as measuring traction forces at cellular focal adhesions or thrashing forces of multicellular organisms. In this study, we present a generalized semi-automated computational framework for the design of the micropillar array systems as well as force analysis and visualization of experimental data obtained with micropillar arrays. Two case studies involving cell traction forces and C. elegans thrashing forces are presented that showcase the widespread utility of this framework. Our approach provides increased levels of accuracy over traditional analytical approaches, especially at the edges of the micropillar array design envelope.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages342-343
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Keywords

  • C. elegans
  • Cell traction forces
  • FEM
  • Mechanobiology
  • Micropillar array

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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