A herringbone microfluidic probe for affinity separation of cells

Ayoub Glia, Pavithra Sukumar, Muhammedin Deliorman, Mohammad A. Qasaimeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work introduces a new concept of capturing cells on functionalized substrates within an open microfluidic system. The capture substrate is physically decoupled from the microfluidic delivery system and thus it can be independently functionalized with multiple recognition biomolecules such as antibodies and aptamers. Further, captured cells can be characterized without releasing them from the substrate (e.g. nano-mechanical phenotyping using atomic force microscopy), can be locally tested with drugs, and can be selectively lysed and analyzed. Hence, the developed tool opens new venues for researchers with interest in the study of circulating tumor cells.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages630-631
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

Keywords

  • Circulating Tumor Cells
  • Herringbone Micromixers
  • Immuno-Capture
  • Microfluidic Probe

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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