A joint framework for 4D segmentation and estimation of smooth temporal appearance changes

Yang Gao, Marcel Prastawa, Martin Styner, Joseph Piven, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Medical imaging studies increasingly use longitudinal images of individual subjects in order to follow-up changes due to development, degeneration, disease progression or efficacy of therapeutic intervention. Repeated image data of individuals are highly correlated, and the strong causality of information over time lead to the development of procedures for joint segmentation of the series of scans, called 4D segmentation. A main aim was improved consistency of quantitative analysis, most often solved via patient-specific atlases. Challenging open problems are contrast changes and occurance of subclasses within tissue as observed in multimodal MRI of infant development, neurodegeneration and disease. This paper proposes a new 4D segmentation framework that enforces continuous dynamic changes of tissue contrast patterns over time as observed in such data. Moreover, our model includes the capability to segment different contrast patterns within a specific tissue class, for example as seen in myelinated and un-myelinated white matter regions in early brain development. Proof of concept is shown with validation on synthetic image data and with 4D segmentation of longitudinal, multimodal pediatric MRI taken at 6, 12 and 24 months of age, but the methodology is generic w.r.t. different application domains using serial imaging.

    Original languageEnglish (US)
    Title of host publication2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages1291-1294
    Number of pages4
    ISBN (Electronic)9781467319591
    DOIs
    StatePublished - Jul 29 2014
    Event2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing, China
    Duration: Apr 29 2014May 2 2014

    Publication series

    Name2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014

    Other

    Other2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
    CountryChina
    CityBeijing
    Period4/29/145/2/14

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'A joint framework for 4D segmentation and estimation of smooth temporal appearance changes'. Together they form a unique fingerprint.

  • Cite this

    Gao, Y., Prastawa, M., Styner, M., Piven, J., & Gerig, G. (2014). A joint framework for 4D segmentation and estimation of smooth temporal appearance changes. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 1291-1294). [6868113] (2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/isbi.2014.6868113