A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study

Jaesok Yu, Joel S. Schuman, Jung Kun Lee, Sang Goo Lee, Jin Ho Chang, Kang Kim

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Photoacoustic (PA) imaging detects acoustic signals generated by thermal expansion of a light-excited tissue or contrast agents. PA signal amplitude and image quality directly depend on the light fluence at the target depth. With conventional PA imaging systems, approximately 30% energy of incident light at the near-infrared region would be lost due to reflection on the skin surface. Such light loss directly leads to a reduction of PA signal and image quality. A new light delivery scheme that collects and redistributes reflected light energy was recently suggested, which is called the light catcher. In our previous study, proof of concept using a finite-element simulation model was shown and a laboratory-built prototype of the light catcher was applied on tissue-mimicking phantoms. In this paper, we present an elaborate prototype of a high-frequency PA probe with the light catcher fabricated using 3-D printing technology, which is conformal to a subcutaneous tumor in mice. The in vivo usefulness of the developed prototype was evaluated in a mouse tumor model. Equipped with the light catcher, PA signal amplitude from the clinical photosensitizer injected into the mouse tumor was enhanced by 33.7%, which is approximately equivalent to the percent light loss due to reflection on the skin.

    Original languageEnglish (US)
    Article number7944618
    Pages (from-to)1205-1211
    Number of pages7
    JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    Volume64
    Issue number8
    DOIs
    StatePublished - Aug 2017

    Keywords

    • Laser illumination scheme
    • light catcher
    • optical scattering
    • photoacoustic (PA) imaging
    • tumor imaging

    ASJC Scopus subject areas

    • Instrumentation
    • Acoustics and Ultrasonics
    • Electrical and Electronic Engineering

    Fingerprint Dive into the research topics of 'A Light Illumination Enhancement Device for Photoacoustic Imaging: In Vivo Animal Study'. Together they form a unique fingerprint.

    Cite this