A link between transcription and intermediary metabolism: A role for Sir2 in the control of acetyl-coenzyme A synthetase

V. J. Starai, H. Takahashi, J. D. Boeke, J. C. Escalante-Semerena

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    The silent information regulator protein (Sir2) and its homologs (collectively known as sirtuins) are NAD+-dependent deacetylase enzymes involved in chromosome stability, gene silencing and cell aging in eukaryotes and archaea. The discovery that sirtuin-dependent protein deacetylation is a NAD+-consuming reaction established a link with the energy generation systems of the cell. This link to metabolism was recently extended to the post-translational control of the activity of short-chain fatty acyl-coenzyme A (adenosine monophosphate-forming) synthetases in bacteria and yeast. The crystal structure of the Sir protein complexed with a peptide of a protein substrate provided insights into how sirtuins interact with their protein substrates.

    Original languageEnglish (US)
    Pages (from-to)115-119
    Number of pages5
    JournalCurrent Opinion in Microbiology
    Volume7
    Issue number2
    DOIs
    StatePublished - Apr 2004

    Keywords

    • 2′-O-acetyl-adenosine diphosphate ribose
    • AMP
    • Acetyl-coenzyme A synthetase
    • Acs
    • Adenosine monophosphate
    • CoA
    • Coenzyme A
    • NAD
    • NADH
    • OAADPr
    • Oxidized nicotinamide adenine dinucleotide
    • Reduced NAD
    • Silent information regulator
    • Sir2

    ASJC Scopus subject areas

    • Microbiology
    • Microbiology (medical)
    • Infectious Diseases

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