@inproceedings{b2cb4849117a4589a2e753ab2874c9b4,
title = "A microfluidic system for saliva-based detection of infectious diseases",
abstract = "A {"}lab-on-a-chip{"} system for detecting bacterial pathogens in oral fluid samples is described. The system comprises : (1) an oral fluid sample collector; (2) a disposable, plastic microfluidic cassette ({"}chip{"}) for sample processing including immunochromatographic assay with a nitrocellulose lateral flow strip; (3) a platform that controls the cassette operation by providing metered quantities of reagents, temperature regulation, valve actuation; and (4) a laser scanner to interrogate the lateral flow strip. The microfluidic chip hosts a fluidic network for cell lysis, nucleic acid extraction and isolation, PCR, and labeling of the PCR product with bioconjugated, upconverting phosphor particles for detection on the lateral flow strip.",
keywords = "Diagnostics, Immunochromatography, Infectious diseases, Lab-on-a-chip, Microfluidics",
author = "Zongyuan Chen and Mauk, {Michael G.} and Jing Wang and Abrams, {William R.} and Corstjens, {Paul L.A.M.} and Niedbala, {R. Sam} and Daniel Malamud and Bau, {Haim H.}",
year = "2007",
month = mar,
doi = "10.1196/annals.1384.024",
language = "English (US)",
isbn = "157331661X",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "429--436",
booktitle = "Oral-based Diagnostics",
}