A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain

Jessica E. Kleinbart, Amy L. Orsborn, John S. Choi, Charles Wang, Shaoyu Qiao, Jonathan Viventi, Bijan Pesaran

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

Original languageEnglish (US)
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3362-3365
Number of pages4
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2018-July
ISSN (Print)1557-170X

Other

Other40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period7/18/187/21/18

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain'. Together they form a unique fingerprint.

  • Cite this

    Kleinbart, J. E., Orsborn, A. L., Choi, J. S., Wang, C., Qiao, S., Viventi, J., & Pesaran, B. (2018). A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 3362-3365). [8512993] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8512993