TY - GEN
T1 - A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain
AU - Kleinbart, Jessica E.
AU - Orsborn, Amy L.
AU - Choi, John S.
AU - Wang, Charles
AU - Qiao, Shaoyu
AU - Viventi, Jonathan
AU - Pesaran, Bijan
N1 - Funding Information:
*Research supported by the National Institute of Health (U01-NS099967, U01-NS103518) and by the Defense Advanced Research Project Agency contracts 911NFW-1-2-40,0 N460136-1-C-742,0 0 HR0011-14-C-0102. J. E. Kleinbart, A. L. Orsborn, J. S. Choi, S. Qiao, and B. Pesaran are with the Center for Neural Science, New York University, New York, NY, 10003, USA. C. Wang and J. Viventi are with the Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Corresponding author: Bijan Pesaran (email: bijan @ nyu.edu)
Publisher Copyright:
© 2018 IEEE.
PY - 2018/10/26
Y1 - 2018/10/26
N2 - Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.
AB - Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.
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U2 - 10.1109/EMBC.2018.8512993
DO - 10.1109/EMBC.2018.8512993
M3 - Conference contribution
C2 - 30441108
AN - SCOPUS:85056586150
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3362
EP - 3365
BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Y2 - 18 July 2018 through 21 July 2018
ER -