A new framework for analyzing white matter maturation in early brain development

Marcel Prastawa, Neda Sadeghi, John H. Gilmore, Weili Lin, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The trajectory of early brain development is marked by rapid growth presented by volume but also by tissue property changes. Capturing regional characteristics of axonal structuring and myelination via neuroimaging requires analysis of longitudinal image data with multiple modalities. Complementary to earlier studies of volume and cortical folding analysis, this paper focuses on white matter tissue changes as seen in multimodal MRI and DTI. We propose a new framework for analyzing early maturation in white matter that generates a normative spatiotemporal model and provides 3D maps of absolute and relative indices of maturation. The method, using a continuous model of intensity changes using modified Legendre polynomials, has been applied to a multimodal dataset (T1W, T2W, PD, DTI) with 8 subjects that have been scanned at approximately 2 weeks, 1 year, and 2 years. We demonstrate that spatial maturation maps generated from different modalities capture different properties of white matter growth which might lead to a better understanding of the underlying neurobiology.

    Original languageEnglish (US)
    Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
    Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
    Pages97-100
    Number of pages4
    DOIs
    StatePublished - 2010
    Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
    Duration: Apr 14 2010Apr 17 2010

    Publication series

    Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

    Other

    Other7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
    CountryNetherlands
    CityRotterdam
    Period4/14/104/17/10

    Keywords

    • Brain development
    • Diffusion tensor imaging
    • Growth trajectory
    • Longitudinal analysis
    • MRI

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Prastawa, M., Sadeghi, N., Gilmore, J. H., Lin, W., & Gerig, G. (2010). A new framework for analyzing white matter maturation in early brain development. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 97-100). [5490404] (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490404