A new heart for a new head in vertebrate cardiopharyngeal evolution

Rui Diogo; Robert G. Kelly; Lionel Christiaen; Michael Levine; Janine M. Ziermann; Julia L. Molnar; Drew M. Noden; Eldad Tzahor

doi:10.1038/nature14435

A new heart for a new head in vertebrate cardiopharyngeal evolution

Rui Diogo, Robert G. Kelly, Lionel Christiaen, Michael Levine, Janine M. Ziermann, Julia L. Molnar, Drew M. Noden, Eldad Tzahor

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

It has been more than 30 years since the publication of the new head hypothesis, which proposed that the vertebrate head is an evolutionary novelty resulting from the emergence of neural crest and cranial placodes. Neural crest generates the skull and associated connective tissues, whereas placodes produce sensory organs. However, neither crest nor placodes produce head muscles, which are a crucial component of the complex vertebrate head. We discuss emerging evidence for a surprising link between the evolution of head muscles and chambered hearts-both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal field of vertebrate embryos. We consider the origin of this field in non-vertebrate chordates and its evolution in vertebrates.

Original language	English (US)
Pages (from-to)	466-473
Number of pages	8
Journal	Nature
Volume	520
Issue number	7548
DOIs	https://doi.org/10.1038/nature14435
State	Published - Apr 23 2015

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title = "A new heart for a new head in vertebrate cardiopharyngeal evolution",

abstract = "It has been more than 30 years since the publication of the new head hypothesis, which proposed that the vertebrate head is an evolutionary novelty resulting from the emergence of neural crest and cranial placodes. Neural crest generates the skull and associated connective tissues, whereas placodes produce sensory organs. However, neither crest nor placodes produce head muscles, which are a crucial component of the complex vertebrate head. We discuss emerging evidence for a surprising link between the evolution of head muscles and chambered hearts-both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal field of vertebrate embryos. We consider the origin of this field in non-vertebrate chordates and its evolution in vertebrates.",

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AU - Diogo, Rui

AU - Kelly, Robert G.

AU - Christiaen, Lionel

AU - Levine, Michael

AU - Ziermann, Janine M.

AU - Molnar, Julia L.

AU - Noden, Drew M.

AU - Tzahor, Eldad

PY - 2015/4/23

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A new heart for a new head in vertebrate cardiopharyngeal evolution

Abstract

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