A non-sister act: Recombination template choice during meiosis

Neil Humphryes, Andreas Hochwagen

Research output: Contribution to journalReview article

Abstract

Meiotic recombination has two key functions: the faithful assortment of chromosomes into gametes and the creation of genetic diversity. Both processes require that meiotic recombination occurs between homologous chromosomes, rather than sister chromatids. Accordingly, a host of regulatory factors are activated during meiosis to distinguish sisters from homologs, suppress recombination between sister chromatids and promote the chromatids of the homologous chromosome as the preferred recombination partners. Here, we discuss the recent advances in our understanding of the mechanistic basis of meiotic recombination template choice, focusing primarily on developments in the budding yeast, Saccharomyces cerevisiae, where the regulation is currently best understood.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalExperimental Cell Research
Volume329
Issue number1
DOIs
StatePublished - Nov 15 2014

Keywords

  • Cohesin
  • Homologous Recombination
  • Meiosis
  • Recombinase
  • Template

ASJC Scopus subject areas

  • Cell Biology

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