A Novel Tubular Scaffold for Cardiovascular Tissue Engineering

Michael J. Yost, Catalin F. Baicu, Charles E. Stonerock, Richard L. Goodwin, Robert L. Price, Jeffrey M. Davis, Heather Evans, Phillip D. Watson, C. Michael Gore, Janea Sweet, Laura Creech, Michael R. Zile, Louis Terracio

Research output: Contribution to journalArticle

Abstract

We have developed a counter rotating cone extrusion device to produce the next generation of three-dimensional collagen scaffold for tissue engineering. The device can produce a continuously varying fibril angle from the lumen to the outside of a 5-mm-diameter collagen tube, similar to the pattern of heart muscle cells in the intact heart. Our scaffold is a novel, oriented, type I collagen, tubular scaffold. We selected collagen because we believe there are important signals from the collagen both geometrically and biochemically that elicit the in vivo-like phenotypic response from the cardiomyocytes. We have shown that cardiomyocytes can be cultured in these tubes and resemble an in vivo phenotype. This new model system will provide important information leading to the design and construction of a functional, biologically based assist device.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalTissue Engineering
Volume10
Issue number1-2
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Cell Biology

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