A nuclear matrix protein stabilized by lead exposure: Current knowledge and future prospects

K. R. Shelton, P. M. Egle, J. W. Bigbee, E. Klann

Research output: Contribution to journalReview article

Abstract

p32/6.3, a low-abundance, highly conserved nuclear protein, is a target for lead. Very few low abundance nuclear proteins have been described and no others have been associated with lead. Its wide distribution and conservation indicate a fundamental nuclear role. Further, it increases many fold in grey matter of brain and spinal cord during the neonatal period; there are no other identified nuclear proteins which serve as markers for this period of nervous system development. There are several links between lead and p32/6.3. It is a major component of lead-induced intranuclear inclusion bodies from the kidney. Its accumulation in kidney is a relatively early event in the process of lead intoxication. Exposure to lead increases p32/6.3 in mouse neuroblastoma 2a cells within one day, blocking its degradation almost completely. These observations suggest that lead either structurally alters p32/6.3 or inhibits a protease for which p32/6.3 is a substrate. In these lead-treated cells nuclear envelope invaginations and small nuclear bodies increase. The possible involvement of lead and p32/6.3 with the formation and movement of nuclear bodies is discussed.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalNeuroToxicology
Volume14
Issue number2-3
StatePublished - 1993

Keywords

  • Developing Brain
  • Inclusion Bodies
  • Lead
  • Nuclear Matrix

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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